Delving into the Latest Updates on Riboflavin Butyrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Riboflavin 2',3',4',5'-tetrabutyrate, Riboflavin Tetabutyrate, Riboflavin butyrate (JP17)

+ [6]

Target-

Action-

Mechanism-

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

HypercholesterolemiaRiboflavin Deficiency

Inactive Indication-

Originator Organization

Mitsubishi Tanabe Pharma Corp.

Active Organization

Nipro ES Pharma KK

Chengdu Lier Pharmaceuticals Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (28 Sep 1979),

HypercholesterolemiaRiboflavin Deficiency

Regulation-

Login to view timeline

Structure/Sequence

Molecular FormulaC33H44N4O10

InChIKeyMJNIWUJSIGSWKK-BBANNHEPSA-N

CAS Registry752-56-7

Corneal collagen crosslinking has been demonstrated as an effective method of reducing progression of both keratoconus and post-refractive corneal ectasia, as well as decreasing the steepness of the cornea in these pathologies.
Performing an accelerated CXL procedure with pulsed UVA light may increase the oxygenation of the cornea, which may improve the crosslinking efficacy.

Start Date30 Jul 2021

Sponsor / Collaborator-

NCT04905108

/ RecruitingPhase 3

Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking Using Two Different Riboflavin Administration Protocols

Corneal collagen crosslinking (CXL) has been demonstrated as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these pathologies. Transepithelial crosslinking in which the epithelium is not removed has been proposed to offer a number of advantages over traditional crosslinking including an increased safety profile by reducing the risk for infection and scarring, faster visual recovery and improved patient comfort in the early postoperative healing period.

Start Date02 Jun 2021

Sponsor / Collaborator-

100 Clinical Results associated with Riboflavin Butyrate

Login to view more data

100 Translational Medicine associated with Riboflavin Butyrate

Login to view more data

100 Patents (Medical) associated with Riboflavin Butyrate

Login to view more data

317

Literatures (Medical) associated with Riboflavin Butyrate

01 Apr 2023·International Journal of Food Science & Technology

Nanoemulsions loaded with compound photosensitisers: synergistic photodynamic inactivation effects of curcumin and riboflavin tetra butyrate

Author: Zhuang, Hong ; Yuan, Yuan ; Fang, Qiangsheng ; Zhang, Yushu ; Li, Rui ; Zhang, Chunling

SummaryAntimicrobial photodynamic therapy (aPDT) is an effective method in the field of sterilisation. Singlet oxygen (1O2) is an important substance in photodynamic sterilisation that needs to be detected. It involves energy transfer from an excited photosensitiser to surrounding oxygen molecules to produce cytotoxic 1O2 species, a process termed as type II reaction. Traditional photodynamic sterilisation for fresh produce generally involves only a single photosensitiser and uses nanoemulsions coating to make the photosensitiser work better. This allows the emulsion to produce only a limited amount of reactive oxygen species (ROS) in the presence of light, such that the bactericidal effect is limited. We have innovatively compounded two photosensitisers and stored them as nanoemulsions. The composite photosensitiser produces relatively higher ROS and the nanoemulsions have good stability as well as rheological properties, and the photosensitisers are well coated in the emulsions. In summary, nanoemulsions based on composite photosensitisers showed synergistic activity in controlling the growth of Staphylococcus aureus, which provides a novel approach for raw sterilisation to maintain food safety.

18 Jan 2023·Chemistry – A European Journal

Multistimuli‐Responsive Chromism of Vinylene‐Linked Bisflavin Based on the Aggregation and Redox Properties

Article

Author: Okamoto, Koyo ; Li, Zimeng ; Kawamorita, Soichiro ; Naota, Takeshi

AbstractMultistimuli‐responsive chromism was observed for vinylene‐linked bisflavin 1 a with an extended π‐conjugated platform. The yellow emission of a dilute solution of 1 a in CHCl3 (0.2 mM) observed at 298 K under UV excitation was changed to orange or red emission upon (1) an increase of concentration, (2) a decrease of temperature, and (3) variation of the solvent. This is in contrast to the almost non stimuli‐responsive chromism of the N‐methylated bisflavin analogue 1 b and monoflavin 2 a. Mechanistic investigation by 1H NMR analysis under various conditions revealed that the extended π‐conjugation platform and imide moiety of 1 a generate controllability in the formation of lower‐ and higher‐ordered aggregates, which induce variation of the emission color upon change. Bisflavin 1 a also exhibited redox‐induced chromism, where the orange emission of 1 a was quenched by the addition of hydrazine under anaerobic conditions, and changed back to the original emission upon subsequent bubbling of O2 gas.

16 Aug 2022·ACS Macro Letters

Versatile Method of Generating Triboluminescence in Polymer Films Blended with Common Luminophores

Article

Author: Khusnutdinova, Julia R. ; Fayzullin, Robert R. ; Karimata, Ayumu

Herein we report a versatile method for the preparation of triboluminescent polymer films by physical blending with common luminophores. This method does not require the presence of a crystalline phase or the use of materials known to be triboluminescent. Emission is generated in response to friction of the polymer surface via triboelectrification, either by rubbing directly or through an inert coating layer, even with low applied stress (<0.1 MPa). Our findings offer a convenient and practical method of preparation of triboluminescent, amorphous polymer films with easily tunable emission properties.

100 Deals associated with Riboflavin Butyrate

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
D01913	-	S01XA26	DB14727

R&D Status

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Hypercholesterolemia	Japan	Nipro ES Pharma KK	28 Sep 1979
Riboflavin Deficiency	Japan	Nipro ES Pharma KK	28 Sep 1979

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00674661 (CXL, CTgov)	Phase 3	Corneal ectasia	130	UVA Irradiation+riboflavin ophthalmic solution (Corneal Collagen Cross-linking (CXL) Treatment Group)	fdqqijkflg(kirhxkcghe) = gxlirizsxa fkbwjmahub (ikpxvjajwf, mtbfeziwwx - hnyqddzqbi) View more	-	27 Jan 2017
				riboflavin ophthalmic solution (Control Group)	fdqqijkflg(kirhxkcghe) = qoxjggqalx fkbwjmahub (ikpxvjajwf, pkkxpwrkgn - beaflklzfy) View more
NCT00647699 (CXL, CTgov)	Phase 3	Keratoconus	147	UVA Irradiation+riboflavin ophthalmic solution (Corneal Collagen Cross-linking (CXL) Treatment Group)	lsvkazhhja(tocxecerxy) = heqesaibyb lfcvdktywn (ctphqgxmnc, aimljqmbqv - oqucgglaxu) View more	-	07 Jul 2016
				riboflavin ophthalmic solution (Control Group)	lsvkazhhja(tocxecerxy) = jlvylurrpy lfcvdktywn (ctphqgxmnc, ppcqzzziis - ypqytusmny) View more
NCT01190306 (CTgov)	Phase 3	Keratoconus	127	The VEGA UV-A Illumination System+Riboflavin (CXL Treatment)	nojyijkwkl(rmlezdntvo) = uzxklmorqh zwqkmwisth (wcgxipwvcv, bsvoxfgamm - epufmdcruq) View more	-	04 Mar 2013
				Riboflavin (Sham Control)	nojyijkwkl(rmlezdntvo) = tqcmauzcop zwqkmwisth (wcgxipwvcv, ymaqrbhqle - mjzkxqutll) View more
NCT01398839 (CTgov)	Phase 3	-	103	VEGA UV-A Illumination System+Riboflavin (CXL Treatment)	zzhftpfzdc(ttqwiggoyv) = wonffzsksb crvxreykei (nkiyiqsllz, cvvvmucwzv - vyflsnowob) View more	-	04 Mar 2013
				Riboflavin (Sham Control)	zzhftpfzdc(ttqwiggoyv) = ztnzeihezf crvxreykei (nkiyiqsllz, upoktxiewm - qgpdyecrdj) View more