Last update 01 Nov 2024

Rexlemestrocel-L

Overview

Basic Info

Drug Type
Mesenchymal stem cell therapy
Synonyms
Allogeneic STRO3 immunoselected bone marrowderived mesenchymal precursor cells (MPCs) Mesoblast, Allogeneic mesenchymal precursor cells Mesoblast, Mesenchymal stem cell therapy Mesoblast
+ [3]
Target-
Mechanism
Cell replacements
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationRare Pediatric Disease (US), Orphan Drug (US), Regenerative Medicine Advanced Therapy (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Low Back PainPhase 3
US
06 Mar 2015
Low Back PainPhase 1
AU
06 Mar 2015
Intervertebral Disc DegenerationPhase 1
AU
14 Feb 2015
Chronic heart failurePhase 1
US
14 Feb 2014
Chronic heart failurePhase 1
CA
14 Feb 2014
Heart FailurePhase 1
US
21 Jan 2014
Diabetes Mellitus, Type 2Phase 1
US
11 Mar 2012
Acute myocardial infarctionPhase 1
US
-01 Mar 2008
Spinal StenosisPhase 1
US
01 Oct 2007
SpondylolisthesisPhase 1
US
01 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
19
(ufrurfhmej) = Baseline PRA levels were high, with no difference between the groups at 12 months. ixzlvhhrpo (oqezigcquh )
Positive
01 Oct 2023
No Intervention
Phase 3
565
(uqhpirveth): HR = 1.17 (95% CI, 0.81 - 1.69), P-Value = 0.406
Negative
27 Feb 2023
Sham Comparator
Phase 3
404
(Rexlemestrocel-L)
rileudpjoz(midktgxsju) = ruiycndotm pufzghrkyx (kfshpknato, hxqgbcppdk - vbuoqgpuao)
-
18 Jan 2022
(Rexlemestrocel-L + HA)
rileudpjoz(midktgxsju) = jqpywkjpmd pufzghrkyx (kfshpknato, nsbplprsyf - zbotnxuwln)
Phase 2
106
Placebo
(Placebo)
gqulcptjtz(hkrveguuzm) = eadcsoorsr brxktmfduf (niirylcdxo, yuviismdyb - gehctgfhuh)
-
18 Jan 2022
(Mesenchymal Precursor Cells (MPC) 12.5 M)
gqulcptjtz(hkrveguuzm) = nmprzcidbf brxktmfduf (niirylcdxo, nnowalvzti - ycceadvdob)
Phase 3
537
(tykpkbcovl) = ogubgmdsfw kvieetcppb (lsjelfgzye )
Positive
14 Dec 2020
Sham
-
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Regulation

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