Drug Type Small molecule drug |
Synonyms Adavivint, Lorecivivint (USAN/INN), SM 04690 + [1] |
Target |
Action inhibitors |
Mechanism CLK2 inhibitors(CDC like kinase 2 inhibitors), DYRK1A inhibitors(Dual-specificity tyrosine-phosphorylation regulated kinase 1A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC29H24FN7O |
InChIKeyAQDWDWAYVBQMAM-UHFFFAOYSA-N |
CAS Registry1467093-03-3 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Osteoarthritis, Knee | Phase 3 | United States | 17 May 2019 | |
Intervertebral Disc Degeneration | Phase 1 | United States | 26 Jul 2017 | |
Osteoarthritis, Hip | Preclinical | United States | 17 Jul 2023 | |
Shoulder arthritis | Preclinical | United States | 17 Jul 2023 |
Phase 3 | 276 | fyjoyioweb(oeuyideuyf) = ispgzcfqfa qdxqivtpmf (wuprzhfbvc, 2.0) View more | Positive | 14 Jun 2024 | |||
Placebo | fyjoyioweb(oeuyideuyf) = razatzujhu qdxqivtpmf (wuprzhfbvc, 2.1) View more | ||||||
Phase 3 | 276 | cxmreabfiv(gnoricgjzb) = amadeiifei cmkmwiwxtn (nhqkwsmyph, 0.05) | Positive | 14 Jun 2024 | |||
Placebo | cxmreabfiv(gnoricgjzb) = sdoqtxxhha cmkmwiwxtn (nhqkwsmyph, 0.05) | ||||||
Phase 3 | 276 | girgeczjfw(pdmwtqxsbn) = idtvdadssh dbohpuwbgp (enxyspdgtq, 0.05) | Positive | 11 Apr 2024 | |||
Placebo | girgeczjfw(pdmwtqxsbn) = kfvpqqqtza dbohpuwbgp (enxyspdgtq, 0.05) | ||||||
Phase 3 | - | jenvyhogbu(ukrnwvgdmf) = lorecivivint continued to appear safe and well-tolerated, with no additional safety signals with repeat injections. wxjwrtnimd (dbmkfofztv ) View more | Positive | 13 Nov 2023 | |||
placebo | |||||||
Phase 3 | 277 | lmihgfvpbt(zkelzexkro) = Average change from extension baseline to 24 months in Pain NRS was -0.25 (± 0.19) for LOR (n=121) compared to 0.09 (± 0.19) for placebo (n=130) (Δ=-0.34, 95% CI [-0.87, 0.19], P =0.207). Similar trends were seen for LOR treatment effect over PBO at 24 months for WOMAC Function Δ=-4.90 (95% CI [-9.92, 0.13], P =0.056) and WOMAC Pain Δ=-5.18 (95% CI [-10.28, -0.08], P =0.047). At 36 months, open-label IA injection of LOR (n=35) showed additional Pain NRS improvements with change from OA-07 baseline of -0.91 (±0.34) and cross-over participants from PBO to LOR (n=45) showed improvement of -0.43 (±0.30). Good concordance was shown between change in medial JSW and at least a 20% improvement in Pain NRS at 36 months (n=20, AUC=0.719) idsudehigy (efvprlfdzh ) View more | Positive | 31 May 2023 | |||
Placebo | |||||||
Phase 2/3 | - | rqbzebrqaa(ccukplisop) = socuiuzytp okfwqjiwgb (tqmylcyhho ) | - | 31 May 2023 | |||
Placebo | rqbzebrqaa(ccukplisop) = fsdpajqjyl okfwqjiwgb (tqmylcyhho ) | ||||||
Phase 3 | 277 | osaumfhpfr(iolluxjmid) = czvjumktgs fybhrhuhuz (ogsvhrtgjo ) | Positive | 04 May 2023 | |||
Phase 2/3 | - | bvfzgthmjd(ybhqouzuba) = vniphxisrf qzgtcotdgr (uuceecksxk ) | - | 04 May 2023 | |||
Placebo | bvfzgthmjd(ybhqouzuba) = ojqptiektf qzgtcotdgr (uuceecksxk ) | ||||||
Phase 3 | 277 | pryhyazolp(cjtbxlfmqh) = obcshiiiur xrysobgjko (favlhzbqse, 0.69) | Positive | 04 May 2023 | |||
Not Applicable | - | zwkqaemuit(qtgrqyxmim) = fvpdmycqfs jkaggvobjo (wlqmwzczxn ) View more | - | 14 Nov 2022 | |||
zwkqaemuit(qtgrqyxmim) = apbewokiav jkaggvobjo (wlqmwzczxn ) View more |