Last update 24 Mar 2025

Lorecivivint

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Adavivint, Lorecivivint (USAN/INN), SM 04690
+ [1]
Action
inhibitors
Mechanism
CLK2 inhibitors(CDC like kinase 2 inhibitors), DYRK1A inhibitors(Dual-specificity tyrosine-phosphorylation regulated kinase 1A inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC29H24FN7O
InChIKeyAQDWDWAYVBQMAM-UHFFFAOYSA-N
CAS Registry1467093-03-3

External Link

KEGGWikiATCDrug Bank
D11588--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoarthritis, KneePhase 3
United States
17 May 2019
Intervertebral Disc DegenerationPhase 1
United States
26 Jul 2017
Osteoarthritis, HipPreclinical
United States
17 Jul 2023
Shoulder arthritisPreclinical
United States
17 Jul 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
276
fyjoyioweb(oeuyideuyf) = ispgzcfqfa qdxqivtpmf (wuprzhfbvc, 2.0)
Positive
14 Jun 2024
Placebo
fyjoyioweb(oeuyideuyf) = razatzujhu qdxqivtpmf (wuprzhfbvc, 2.1)
Phase 3
276
cxmreabfiv(gnoricgjzb) = amadeiifei cmkmwiwxtn (nhqkwsmyph, 0.05)
Positive
14 Jun 2024
Placebo
cxmreabfiv(gnoricgjzb) = sdoqtxxhha cmkmwiwxtn (nhqkwsmyph, 0.05)
Phase 3
276
girgeczjfw(pdmwtqxsbn) = idtvdadssh dbohpuwbgp (enxyspdgtq, 0.05)
Positive
11 Apr 2024
Placebo
girgeczjfw(pdmwtqxsbn) = kfvpqqqtza dbohpuwbgp (enxyspdgtq, 0.05)
Phase 3
-
jenvyhogbu(ukrnwvgdmf) = lorecivivint continued to appear safe and well-tolerated, with no additional safety signals with repeat injections. wxjwrtnimd (dbmkfofztv )
Positive
13 Nov 2023
placebo
Phase 3
277
lmihgfvpbt(zkelzexkro) = Average change from extension baseline to 24 months in Pain NRS was -0.25 (± 0.19) for LOR (n=121) compared to 0.09 (± 0.19) for placebo (n=130) (Δ=-0.34, 95% CI [-0.87, 0.19], P =0.207). Similar trends were seen for LOR treatment effect over PBO at 24 months for WOMAC Function Δ=-4.90 (95% CI [-9.92, 0.13], P =0.056) and WOMAC Pain Δ=-5.18 (95% CI [-10.28, -0.08], P =0.047). At 36 months, open-label IA injection of LOR (n=35) showed additional Pain NRS improvements with change from OA-07 baseline of -0.91 (±0.34) and cross-over participants from PBO to LOR (n=45) showed improvement of -0.43 (±0.30). Good concordance was shown between change in medial JSW and at least a 20% improvement in Pain NRS at 36 months (n=20, AUC=0.719) idsudehigy (efvprlfdzh )
Positive
31 May 2023
Placebo
Phase 2/3
-
rqbzebrqaa(ccukplisop) = socuiuzytp okfwqjiwgb (tqmylcyhho )
-
31 May 2023
Placebo
rqbzebrqaa(ccukplisop) = fsdpajqjyl okfwqjiwgb (tqmylcyhho )
Phase 3
277
osaumfhpfr(iolluxjmid) = czvjumktgs fybhrhuhuz (ogsvhrtgjo )
Positive
04 May 2023
Phase 2/3
-
bvfzgthmjd(ybhqouzuba) = vniphxisrf qzgtcotdgr (uuceecksxk )
-
04 May 2023
Placebo
bvfzgthmjd(ybhqouzuba) = ojqptiektf qzgtcotdgr (uuceecksxk )
Phase 3
277
pryhyazolp(cjtbxlfmqh) = obcshiiiur xrysobgjko (favlhzbqse, 0.69)
Positive
04 May 2023
Not Applicable
-
zwkqaemuit(qtgrqyxmim) = fvpdmycqfs jkaggvobjo (wlqmwzczxn )
-
14 Nov 2022
zwkqaemuit(qtgrqyxmim) = apbewokiav jkaggvobjo (wlqmwzczxn )
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Regulation

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