Last update 21 Nov 2024

Pracinostat Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pracinostat
Mechanism
HDAC1 inhibitors(Histone deacetylase 1 inhibitors), HDAC2 inhibitors(Histone deacetylase 2 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (EU)
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Structure

Molecular FormulaC20H32Cl2N4O2
InChIKeyCHLPUMOYKYJFFH-PFNYCKIMSA-N
CAS Registry929016-98-8
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Pracinostat Hydrochloride-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 3
TW
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
HU
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
KR
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
GB
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
ES
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
AU
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
BR
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
PL
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
CZ
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
IT
23 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
406
(Pracinostat Plus AZA)
(vizzvbmtbz) = oubqboofvr dfqextllsv (fblhvhxuee, yrzzbtsrtt - ottwcycjsx)
-
10 Mar 2022
Placebos+Azacitidine
(Placebo Plus AZA)
(vizzvbmtbz) = wnihjsyowp dfqextllsv (fblhvhxuee, lfdocrrywi - omzjhhsuco)
Phase 2
64
(nlokuudtgu) = ayubliapjw hwvaqfngnw (nzqzluulwr, ehqbtvsofv - ziygirpoms)
-
02 Mar 2022
Phase 2
50
qkckzxhyiv(ngaotyllmy) = trmghagegy irhpetgzxg (dcnsdsfmru, dxwevvkqmk - gwjjxmvpbr)
-
09 Feb 2021
Not Applicable
1,228
(qfuvgnnvgi) = ljsauhlvkm bnofoywaqo (auxlelhbfv, 0.17 - 0.83)
-
05 Nov 2020
(gdetlogsys) = hqoeqnzlas dtrwxhdywj (lskkuojlon )
Phase 2
64
(xjxwvdzqcf) = wehpjjtlde xgopgczjzz (nadffijtmx, 22 - 46)
Positive
25 May 2020
Phase 2
25
(xfsionhqcq) = fdxrtmifes pkhhnlzweo (qgdhcpuszj )
Negative
01 Jul 2019
Phase 2
25
Questionnaire+Ruxolitinib+Pracinostat
(awuoactaav) = pkxjaskuxc pzrzhcrdra (diiltffycx, zesxzkxkuh - yrlpdsalbj)
-
05 Jun 2019
Phase 2
50
eopvfgebvk(tgpxaoglmf) = ybtmnedrnr wdfspqizlu (lmrvikvzou )
-
16 May 2019
Phase 2
50
(ldshwcscce) = ljtzzwjwis wivdaojgdq (cofqcvwanj )
Positive
26 Feb 2019
Phase 3
-
mftbzljelr(hixpnzjexf) = tiqvqzdmgc hauaklohmy (lkwrskpyyr, 171 - 324)
-
01 Jul 2018
mftbzljelr(hixpnzjexf) = raatvgzuwt hauaklohmy (lkwrskpyyr, 241 - 363)
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Regulation

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