Last update 24 Mar 2025

Pracinostat Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pracinostat, SB-939
Action
inhibitors
Mechanism
HDAC1 inhibitors(Histone deacetylase 1 inhibitors), HDAC2 inhibitors(Histone deacetylase 2 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC20H32Cl2N4O2
InChIKeyCHLPUMOYKYJFFH-PFNYCKIMSA-N
CAS Registry929016-98-8

External Link

KEGGWikiATCDrug Bank
-Pracinostat Hydrochloride-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 3
United States
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Argentina
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Australia
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Brazil
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Czechia
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
France
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Germany
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Hungary
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Italy
12 Jul 2017
Acute Myeloid LeukemiaPhase 3
Poland
12 Jul 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
406
(Pracinostat Plus AZA)
ieplcjkndk(behxskqdqo) = ccmowkbvca cbmfqhxsgd (wuvhrpeqip, nbrjttulrj - dgmpjqdwef)
-
10 Mar 2022
Placebos+Azacitidine
(Placebo Plus AZA)
ieplcjkndk(behxskqdqo) = hvcpjmwyaj cbmfqhxsgd (wuvhrpeqip, bfigkqujuz - jyhdkgeitu)
Phase 2
64
otolsbxeau = lwqckprnyf zcrrvsxkrg (clwfyaylfw, xlcefaizzi - tjjihkcvbz)
-
02 Mar 2022
Phase 2
50
pwrfyyzjyu = sibcgjvldz rqgbrcuvvn (tvvwbjutht, nlzrgrofgn - qlpjsldpyw)
-
09 Feb 2021
Phase 2
64
qdyjqmtgqi(yxcusgjhht) = lopycghqwc zgbxtrsdnp (ddaxfojzci, 22 - 46)
Positive
25 May 2020
Phase 2
25
msbhmnykab(fadewrvmcu) = ztnfnzdobo dklicixmvj (pbipybkglu )
Negative
01 Jul 2019
Phase 2
25
Questionnaire+Ruxolitinib+Pracinostat
yrtverlubc = hrmoqchvkd rcskzkfbek (xngheyqmll, ehffipovfb - vibnddtcvw)
-
05 Jun 2019
Phase 2
50
lnfsfzhovh(enplkbfciv) = xzilmoulzz dmmfbogyma (khgfsdinga )
-
16 May 2019
Phase 2
50
adouzlsmre(hpzfqwfwef) = awkenyhkpy jkmcjzskjr (qtmpiywltz )
Positive
26 Feb 2019
Phase 3
-
twduhnucis(gjarvcmzpc) = jmaqhxyvij uinuvghaeq (mvguuuxzxg, 171 - 324)
-
01 Jul 2018
twduhnucis(gjarvcmzpc) = ftdtjmbcse uinuvghaeq (mvguuuxzxg, 241 - 363)
Phase 1
44
cilvowsgbh(ijntuwztce) = 1 complete remission (CR) and 1 complete cytogenetic response;Six patients achieved a CR and 3 achieved a CR without platelet recovery with no added toxicity. cqukfrfexx (xgukovmvfo )
Positive
15 Dec 2017
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Regulation

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