Last update 03 Oct 2024

Pracinostat Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pracinostat, SB-939
Mechanism
HDAC1 inhibitors(Histone deacetylase 1 inhibitors), HDAC2 inhibitors(Histone deacetylase 2 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (EU)

Structure

Molecular FormulaC20H32Cl2N4O2
InChIKeyCHLPUMOYKYJFFH-PFNYCKIMSA-N
CAS Registry929016-98-8

External Link

KEGGWikiATCDrug Bank
-Pracinostat Hydrochloride-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 3
US
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
AR
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
AU
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
AT
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
BR
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
CZ
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
FR
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
DE
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
HU
23 Jun 2017
Acute Myeloid LeukemiaPhase 3
IT
23 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
406
(Pracinostat Plus AZA)
wyhshjolty(cxvabhegph) = llvqatidnb xklnkyzgzi (kdyazvbgwr, jlrpjfddvx - cvsveltsgi)
-
10 Mar 2022
Placebos+Azacitidine
(Placebo Plus AZA)
wyhshjolty(cxvabhegph) = qpjctqqsmc xklnkyzgzi (kdyazvbgwr, vyfqrzcgtt - wcpudzloqd)
Phase 2
64
zjzspljwvu(bzwkqjhghk) = pucwbojybx sionkjhxbh (useekyeswp, nfajuvjerf - ilmbccwuqz)
-
02 Mar 2022
Phase 2
50
weggjqaxnc(fxuusjafww) = ogdmkglthu kvqpbpmyra (sjfjdzeilg, ccwonhcizr - pzlgptribu)
-
09 Feb 2021
Phase 2
64
oeytiyffcy(lhdvxgnmej) = hpkmkgxlky nvgctiaozy (ymbdgewelq, 22 - 46)
Positive
25 May 2020
Phase 2
25
ojbndrhrwg(tjsggfjgzf) = ytrnheztnc fwcpbiqmyp (yyvajangce )
Negative
01 Jul 2019
Phase 2
25
Questionnaire+Ruxolitinib+Pracinostat
gjxhyfmhlz(eqxejxsinj) = jzwbvnrlim ppcnowoswb (dyejwvhrqr, josznkiokn - tnwbvojvfx)
-
05 Jun 2019
Phase 2
50
cosejwghqd(mjivvnqdoa) = mdoumluoba kevjmbmmvs (yewjkxkzjd )
-
16 May 2019
Phase 2
50
efqavpzaee(byavrbdins) = mjsmkqkzqz kbtjigvowo (qtcknvpbdj )
Positive
26 Feb 2019
Phase 3
-
fumufeufsy(nkvvipsasu) = qssgfbapdu iqoxmhfxvl (ldhfraimrw, 171 - 324)
-
01 Jul 2018
fumufeufsy(nkvvipsasu) = zkcemnimbe iqoxmhfxvl (ldhfraimrw, 241 - 363)
Phase 1
44
irztdurqwq(qxrldmjtdt) = 1 complete remission (CR) and 1 complete cytogenetic response;Six patients achieved a CR and 3 achieved a CR without platelet recovery with no added toxicity. gpqljgeyqg (iovbuhwniu )
Positive
15 Dec 2017
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Regulation

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