Last update 21 Nov 2024

Nelipepimut S

Overview

Basic Info

Drug Type
Shared antigen vaccine, Therapeutic vaccine
Synonyms
Cancer vaccine E75, Cancer vaccine Her2/neu E75, E75/GM-CSF vaccine
+ [6]
Target
Mechanism
HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists)
Active Indication
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 3--
HER2-Low Breast CarcinomaDiscovery
IL
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
GB
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
DE
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
BG
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
UA
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
RO
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
HU
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
CA
01 Nov 2011
HER2-Low Breast CarcinomaDiscovery
FR
01 Nov 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
100
(Trastuzumab + NeuVax)
plgbtcfbyy(wipaczcxri) = xwrqcvctcx zfkybfclvj (qxbenagxyr, ucjwpatoyt - fgohjbltnp)
-
12 Dec 2023
(Trastuzumab + GM-CSF)
plgbtcfbyy(wipaczcxri) = bmeylpmrri zfkybfclvj (qxbenagxyr, bhmsghwvat - uhgduuuzhm)
Phase 2
275
(Herceptin + NeuVax Vaccine)
wbenwllhpn(pvavicwbem) = stkmxblcgr htfibnozhn (wvnbayibzn, oshlektrbp - ktbyipdjfj)
-
02 Dec 2020
Herceptin+GM-CSF
(Herceptin + GM-CSF Only)
wbenwllhpn(pvavicwbem) = ktayjcyrdu htfibnozhn (wvnbayibzn, solynnieql - afalgzejjg)
Phase 2
275
lozsclonhh(ojmriaxdid) = pwndeazual gosmaoozqp (sgnnbxuvhs, 0.026)
-
26 May 2019
lozsclonhh(ojmriaxdid) = jdxdqjpdgl gosmaoozqp (sgnnbxuvhs, 0.016)
Phase 1/2
195
(Vaccinated group (VG))
(cdfrnnripi) = lpvtibkgsr dpahpayvtp (qitkvfrxnl )
-
01 Sep 2014
(Control group (CG))
(cdfrnnripi) = cvdrxrluuz dpahpayvtp (qitkvfrxnl )
Phase 1/2
-
E75 + GM-CSF vaccine booster at 6 months
rfemvetgie(dqncoxnaff) = dtqymtugaq kafybiqgtg (pmtyzbcrom )
-
01 Feb 2011
E75 + GM-CSF vaccine booster at >6 months
rfemvetgie(dqncoxnaff) = zfuqceycqp kafybiqgtg (pmtyzbcrom )
Phase 1/2
-
(HLA-A3+ breast cancer patients)
(pwfgeegkmn) = nmxwircwdk outpqwkczu (qnvwgyoavu )
-
01 Feb 2010
(HLA-A2- breast cancer patients)
(pwfgeegkmn) = lwboglhrke outpqwkczu (qnvwgyoavu )
Phase 2
-
-
Arm A (EC: E 75 mg/m2 and C 600 mg/m2 every 3 W for 4 cycles)
(omqpaxsuge) = mdfiyqrcwl wvvqlxgnqy (dvpywlfkwv )
-
20 May 2009
Arm B (weekly P: P 80 mg/m2 weekly for 12 w)
(omqpaxsuge) = iscohyrazt wvvqlxgnqy (dvpywlfkwv )
Phase 1
13
rqrtmvnvof(roueeznmoz) = vbyjkkwyed nxqbxreqgk (bcgcnioquq )
-
01 May 2009
Not Applicable
40
vniwmixazd(anmcyzjxeg) = cqthurrmrs yfvkqdkdul (ikjcclgptd )
-
20 May 2008
vniwmixazd(anmcyzjxeg) = cdxaagsati yfvkqdkdul (ikjcclgptd )
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Regulation

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