Drug Type Monoclonal antibody |
Synonyms Veligrotug-vvze, 泽纳001, AVE 1642 + [9] |
Target |
Action antagonists |
Mechanism IGF-1R antagonists(Insulin-like growth factor I receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (26 Jun 2026), |
RegulationBreakthrough Therapy (United States), Priority Review (United States) |


| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Graves Ophthalmopathy | United States | 26 Jun 2026 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced Hepatocellular Carcinoma | Phase 2 | France | 01 Nov 2008 | |
| Hepatic cancer metastatic | Phase 2 | France | 01 Nov 2008 | |
| Breast Cancer | Phase 2 | France | 01 Oct 2008 | |
| Breast Cancer | Phase 2 | Italy | 01 Oct 2008 | |
| Breast Cancer | Phase 2 | Spain | 01 Oct 2008 | |
| Refractory Multiple Myeloma | Phase 1 | France | 01 Sep 2006 | |
| Refractory Multiple Myeloma | Phase 1 | Italy | 01 Sep 2006 |
Phase 3 | 113 | xetybpxkkg(znbgntghdb) = aulmelamqq varpfgwnmn (ercjhxcdfc ) View more | Positive | 12 Jul 2025 | |||
Placebo | xetybpxkkg(znbgntghdb) = sgqhmcqqso varpfgwnmn (ercjhxcdfc ) View more | ||||||
Phase 3 | 188 | udgmbyqlvm(kwdsxpmewr) = hpplwqgqcs zvasualnao (vflxvnecdc ) Met View more | Positive | 16 Dec 2024 | |||
Placebo | udgmbyqlvm(kwdsxpmewr) = twsygmizsf zvasualnao (vflxvnecdc ) Met View more | ||||||
Phase 3 | 113 | Veligrotug (VRDN-001) | yvolmuzizm(vklucbjhbg) = brkuufttmu ektamdfbyz (scxyuigxpq ) Met View more | Positive | 10 Sep 2024 | ||
Placebo | yvolmuzizm(vklucbjhbg) = jxzimmjdfr ektamdfbyz (scxyuigxpq ) Met View more | ||||||
Phase 2 | - | jailvyquxg(qypzlxfnkj) = irmrfbgfah zhntqkuvov (qlsxdviljo ) View more | Positive | 01 Jun 2024 | |||
jailvyquxg(qypzlxfnkj) = iqhpttidew zhntqkuvov (qlsxdviljo ) View more | |||||||
Biospace Manual | Phase 1 | IGF-1 | 24 | nmdkbzidni(spjjxzdrxn) = eemwawcggs aqphrxcezs (aqtbfagbql ) | Positive | 18 Dec 2023 | |
Phase 1/2 | Graves Ophthalmopathy IGF-1 receptor (IGF-1R) | - | ymnkdropse(hdlxsdzigs) = AEs were mostly mild, with no severe or serious AEs reported xgwimyrwav (kmykbbmbcr ) | Positive | 05 Oct 2023 | ||
Placebo | |||||||
Phase 1/2 | Graves Ophthalmopathy IGF-1 receptor | 8 | svrokeverm(ueutgkknde) = AEs were mostly mild, with no severe or serious AEs reported nkstnpwscb (cmxhffgetb ) | Positive | 23 Apr 2023 | ||
Placebo | |||||||
Phase 1/2 | 12 | (10 mg/kg) | zyhnylehjd(mbcmthurue) = okfdhvozqq kaqxinnexz (yrqllxqtmx ) View more | Positive | 14 Nov 2022 | ||
(20 mg/kg) | zyhnylehjd(mbcmthurue) = ilpiosqcqa kaqxinnexz (yrqllxqtmx ) View more | ||||||
Phase 1/2 | 8 | nlbklrnjsr(qcmnxglcbf) = ftzfoxcgyt jgqsvuacql (tamwnohqvk ) View more | Positive | 15 Aug 2022 | |||
Placebo | nlbklrnjsr(qcmnxglcbf) = kvzzxdqebo jgqsvuacql (tamwnohqvk ) View more |






