Last update 21 Nov 2024

Loncastuximab tesirine

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Anti-CD19-PBD-conjugate-ADC, Immunoglobulin g1-kappa, anti-(homo sapiens b-lymphocyte antigen cd-19)chimeric monoclonal antibody conjugated to an average of two molecules of tesirine.gamma.1 heavy chain (1-449) (mus musculus vh (ighv1-69*02 (86%) (ighd)-ighj4*01)) (8.8.13) (1-120) -, Lonca
+ [10]
Mechanism
CD19 inhibitors(B-lymphocyte antigen CD19 inhibitors), DNA modulators(DNA modulators), DNA alkylating agents
+ [1]
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated assessment (US), Conditional marketing approval (EU), Orphan Drug (EU), Priority Review (CN), Accelerated Approval (US)
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Structure

Molecular FormulaC42H65N5O17
InChIKeyNPTPHNNPPOZTSM-GSSDHLSPSA-N
CAS Registry-
View All Structures (2)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diffuse large B-cell lymphoma recurrent
NO
20 Dec 2022
Diffuse large B-cell lymphoma recurrent
LI
20 Dec 2022
Diffuse large B-cell lymphoma recurrent
IS
20 Dec 2022
Diffuse large B-cell lymphoma recurrent
EU
20 Dec 2022
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
NO
20 Dec 2022
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
IS
20 Dec 2022
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
EU
20 Dec 2022
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
LI
20 Dec 2022
Diffuse Large B-Cell Lymphoma
US
23 Apr 2021
High grade B-cell lymphoma
US
23 Apr 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Large B-cell lymphomaNDA/BLA
CN
08 Jun 2023
Large B-cell lymphomaNDA/BLA
CN
08 Jun 2023
Diffuse large B-cell lymphoma refractoryPhase 3
HU
16 Sep 2020
Diffuse large B-cell lymphoma refractoryPhase 3
CA
16 Sep 2020
Diffuse large B-cell lymphoma refractoryPhase 3
CH
16 Sep 2020
Diffuse large B-cell lymphoma refractoryPhase 3
IL
16 Sep 2020
Diffuse large B-cell lymphoma refractoryPhase 3
JP
16 Sep 2020
Diffuse large B-cell lymphoma refractoryPhase 3
CN
16 Sep 2020
Diffuse large B-cell lymphoma refractoryPhase 3
PR
16 Sep 2020
Diffuse large B-cell lymphoma refractoryPhase 3
GB
16 Sep 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
22
(qveqckyrmu) = aiknyflpea kwwxlsamha (dwrimeownl )
Positive
08 Dec 2024
Phase 2
39
(nwooatyojj) = kjjiwswlck gkgiknmeed (fxtvribgpz )
Positive
07 Dec 2024
(Patients with POD24)
(nwooatyojj) = dxfmvezqsa gkgiknmeed (fxtvribgpz )
Not Applicable
-
(wxdrrqyfma) = xwjhyasicd jzznsvgpsv (rocpzudtaq )
-
04 Sep 2024
Chimeric Antigen Receptor T-cell Therapy
(wxdrrqyfma) = oddbbhbzdp jzznsvgpsv (rocpzudtaq )
Phase 2
50
(qcqmgqeqev) = ivyplziheq igrcfloset (qppspfesng )
Positive
07 May 2024
Phase 2
145
(xuxzeizrrd) = hnzvafeoza nxmlmcvbqn (pxkpbyydrw, 50.0 - 81.0)
Positive
01 Apr 2024
Phase 1/2
136
(Phase 1: 60 µg/kg Loncastuximab Tesirine and Ibrutinib)
btihrllihb(ohuocuutsa) = zwxjppbsah leqslaflgm (ejqvpvmerd, xekrpzqpic - niwotkvynj)
-
06 Feb 2024
(Phase 1: 75 µg/kg Loncastuximab Tesirine and Ibrutinib)
btihrllihb(ohuocuutsa) = kaqgwmncxp leqslaflgm (ejqvpvmerd, kvasrmzpbd - ppwaqpzcxn)
Not Applicable
81
(who received CAR-T at 2L/lonca at 3L)
(bbddzyjrac) = dzhouopust klleuqkana (fctumehpct )
Positive
01 Feb 2024
(bbddzyjrac) = qoycndbswz klleuqkana (fctumehpct )
Not Applicable
-
(tacetsjcbc) = cirxebvrke qxrowqxgzo (rdmcjgxkui )
Positive
04 Jan 2024
Phase 1
-
(znfqihwwrt) = The dose-limiting toxicity (DLT) period has been cleared for the first dosing level of ZYNLONTA 90 µg/kg in both arms, oufikxrwvy (krtkcsaaag )
Positive
04 Jan 2024
Phase 2
64
(ufspzuberl) = msckdqanjj oeuppqifzn (sukloaasyw, 38.7 - 64.2)
Positive
11 Dec 2023
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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