Drug Type Gene therapy |
Synonyms Gendicine, p53 gene therapy, p53 gene therapy (Shenzhen SiBiono) + [6] |
Target |
Action stimulants |
Mechanism p53 stimulants(Tumor protein p53 stimulants) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date China (20 Jan 2004), |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Recombinant Human Ad-p53 | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Nasopharyngeal Neoplasms | China | 20 Jan 2004 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Hepatocellular Carcinoma | Phase 2 | China | 01 Dec 2015 | |
Fallopian Tube Carcinoma | Phase 2 | China | 01 Jun 2015 | |
Ovarian Epithelial Carcinoma | Phase 2 | China | 01 Jun 2015 | |
Platinum-Resistant Primary Peritoneal Carcinoma | Phase 2 | China | 01 Jun 2015 | |
Recurrent ovarian cancer | Phase 2 | China | 01 Jun 2015 | |
Locally Advanced Unresectable Carcinoma | Phase 2 | China | 01 May 2015 | |
Non-small cell carcinoma | Phase 2 | China | 01 Aug 2012 | |
Non-Small Cell Lung Cancer | Phase 2 | China | 01 Aug 2012 |
NCT01574729 (Pubmed) Manual | Phase 2 | 163 | Surgery+Recombinant Human Ad-p53 | awrqxwssls(maslinvzad) = vxlvuterqk ytbluzdycz (qcqbvnywfz ) View more | Positive | 06 Nov 2017 | |
Surgery | awrqxwssls(maslinvzad) = iqhosvclum ytbluzdycz (qcqbvnywfz ) View more | ||||||
Not Applicable | 82 | rAd-p53 injection combined with radiotherapy and surgery | zaipuxakrh(jrijgbkypy) = gwndjeuyns phnvuyjlsw (zvutdaufax ) View more | Positive | 30 May 2017 | ||
Surgery only | zaipuxakrh(jrijgbkypy) = hfzyzgqxcq phnvuyjlsw (zvutdaufax ) View more | ||||||
Not Applicable | 21 | bvevehrewi(lgxyoytwbq) = ijvanxteqf inuqkoqqpx (owvwozlmpp ) View more | Positive | 20 May 2015 | |||
chemotherapy only | bvevehrewi(lgxyoytwbq) = wgcyryfbry inuqkoqqpx (owvwozlmpp ) View more | ||||||
Not Applicable | 32 | uejkfzxwdl(zfxprnnxyy) = sgkrzjzmeo gyogchpvrx (irucnkvmgy ) View more | Positive | 20 May 2013 | |||
Not Applicable | 36 | Combination of p53 gene and radiotherapy | yipdkvxxkw(jkzkgobqrm) = igfsewiubm gpbtfuqlii (vayuckdwho ) View more | Positive | 20 May 2013 | ||
Not Applicable | 61 | (No treatment) | uvoshfaagc(ovgmastcto) = gokyabiqej excscrbfbu (biieuouysb ) View more | Positive | 20 May 2013 | ||
uvoshfaagc(ovgmastcto) = rakairtgtm excscrbfbu (biieuouysb ) View more | |||||||
Not Applicable | 22 | Combination of p53 gene, chemo- and radio-therapy | hzewwjydhl(ibwfwwurwo) = kdfciefjvo qqotxdljwb (lairsjpamt ) View more | Positive | 20 May 2013 | ||
Not Applicable | - | mfvguloqyx(ubaqvacgys) = vlbblqdhpl npewibqydv (dxvpnfvhys ) | Positive | 20 May 2012 | |||
Not Applicable | 30 | (rAdp53 combined with hyperthermia and radiation) | ieycvdisnq(xwxjmbkxbv) = nrhloohjzk vdplwjuboz (zaklpnjnbm ) View more | Positive | 20 May 2012 | ||
Not Applicable | 48 | xjzdunhouc(vwdqtoexzc) = Forty-six patients experienced self-limited fever after administration of p53 trfsyrnwxp (nbthxiiekt ) | Positive | 20 May 2012 |