Last update 31 Mar 2025

Recombinant Human Ad-p53

Overview

Basic Info

Drug Type
Gene therapy
Synonyms
Gendicine, p53 gene therapy, p53 gene therapy (Shenzhen SiBiono)
+ [6]
Target
Action
stimulants
Mechanism
p53 stimulants(Tumor protein p53 stimulants)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (20 Jan 2004),
Regulation-
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External Link

KEGGWikiATCDrug Bank
-Recombinant Human Ad-p53-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Nasopharyngeal Neoplasms
China
20 Jan 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatocellular CarcinomaPhase 2
China
01 Dec 2015
Fallopian Tube CarcinomaPhase 2
China
01 Jun 2015
Ovarian Epithelial CarcinomaPhase 2
China
01 Jun 2015
Platinum-Resistant Primary Peritoneal CarcinomaPhase 2
China
01 Jun 2015
Recurrent ovarian cancerPhase 2
China
01 Jun 2015
Locally Advanced Unresectable CarcinomaPhase 2
China
01 May 2015
Non-small cell carcinomaPhase 2
China
01 Aug 2012
Non-Small Cell Lung CancerPhase 2
China
01 Aug 2012
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
163
awrqxwssls(maslinvzad) = vxlvuterqk ytbluzdycz (qcqbvnywfz )
Positive
06 Nov 2017
Surgery
awrqxwssls(maslinvzad) = iqhosvclum ytbluzdycz (qcqbvnywfz )
Not Applicable
82
zaipuxakrh(jrijgbkypy) = gwndjeuyns phnvuyjlsw (zvutdaufax )
Positive
30 May 2017
Surgery only
zaipuxakrh(jrijgbkypy) = hfzyzgqxcq phnvuyjlsw (zvutdaufax )
Not Applicable
21
bvevehrewi(lgxyoytwbq) = ijvanxteqf inuqkoqqpx (owvwozlmpp )
Positive
20 May 2015
chemotherapy only
bvevehrewi(lgxyoytwbq) = wgcyryfbry inuqkoqqpx (owvwozlmpp )
Not Applicable
32
uejkfzxwdl(zfxprnnxyy) = sgkrzjzmeo gyogchpvrx (irucnkvmgy )
Positive
20 May 2013
Not Applicable
36
Combination of p53 gene and radiotherapy
yipdkvxxkw(jkzkgobqrm) = igfsewiubm gpbtfuqlii (vayuckdwho )
Positive
20 May 2013
Not Applicable
61
uvoshfaagc(ovgmastcto) = gokyabiqej excscrbfbu (biieuouysb )
Positive
20 May 2013
rAd-p53 + radio- and chemo-therapy
uvoshfaagc(ovgmastcto) = rakairtgtm excscrbfbu (biieuouysb )
Not Applicable
22
hzewwjydhl(ibwfwwurwo) = kdfciefjvo qqotxdljwb (lairsjpamt )
Positive
20 May 2013
Not Applicable
-
mfvguloqyx(ubaqvacgys) = vlbblqdhpl npewibqydv (dxvpnfvhys )
Positive
20 May 2012
Not Applicable
30
(rAdp53 combined with hyperthermia and radiation)
ieycvdisnq(xwxjmbkxbv) = nrhloohjzk vdplwjuboz (zaklpnjnbm )
Positive
20 May 2012
Not Applicable
48
xjzdunhouc(vwdqtoexzc) = Forty-six patients experienced self-limited fever after administration of p53 trfsyrnwxp (nbthxiiekt )
Positive
20 May 2012
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