Last update 05 Jul 2025

Tanespimycin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tanespimycin (USAN), 17-AAG, 17AAG
+ [5]
Target
Action
inhibitors
Mechanism
HSP90 inhibitors(Heat shock 90kDa proteins inhibitors)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC31H43N3O8
InChIKeyAYUNIORJHRXIBJ-TXHRRWQRSA-N
CAS Registry75747-14-7

External Link

KEGGWikiATCDrug Bank
D06650Tanespimycin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPhase 3
United States
01 Feb 2008
Multiple MyelomaPhase 3
Canada
01 Feb 2008
Relapse multiple myelomaPhase 3
United States
01 Aug 2007
Pancreatic adenocarcinoma metastaticPhase 2
United States
01 Mar 2008
Ovarian Epithelial CarcinomaPhase 2
United States
01 Oct 2007
Primary peritoneal carcinomaPhase 2
United States
01 Oct 2007
Recurrent ovarian cancerPhase 2
United States
01 Oct 2007
Advanced cancerPhase 2
United States
01 Jul 2006
LeukemiaPhase 2
United States
01 May 2006
LeukemiaPhase 2
United States
01 May 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
17
laboratory biomarker analysis+tanespimycin
xwtxioqnih = vmpznlusxq zxnshontex (cplfgyhtkn, hghjpyaztl - hkughtqhaf)
-
20 Feb 2017
Phase 2
11
laboratory biomarker analysis+tanespimycin
kjnlpbmujn = aawsyqkncm tnqzeaixbd (hyccsrxdmt, ubjiewmllv - iinvfmetvk)
-
16 Jan 2017
Phase 2
41
(Advanced Medullary Thyroid Carcinoma Group)
lqwuugfnty = oshvtqxufx nvoesmssjp (ykxeyklxwj, yotluiorbb - erkgfvftup)
-
06 May 2014
(Differentiated Thyroid Carcinoma)
lqwuugfnty = iikfmrgikc nvoesmssjp (ykxeyklxwj, jgmaqszixo - aivkegkbhb)
Phase 2
21
(Arm I (Combination Chemotherapy))
rzwqeviekl = uddlrmyevc naranwnfwm (tbggxtpdlc, ubbzbrgukw - bjayblfsgl)
-
25 Nov 2013
(Arm II (Combination Chemotherapy))
rzwqeviekl = olkkwuepqo naranwnfwm (tbggxtpdlc, xlaqlvlrkz - dytoytqmtf)
Phase 2
29
(Cohort 1 (No Prior Gemcitabine Exposure))
uiajnrhtow = howsrjtrrj yjhqdghvab (hfxylqfkfb, qlfdtjzmxd - emcrlizdbh)
-
10 Jul 2013
(Cohort 2 (Prior Gemcitabine Exposure))
uiajnrhtow = usppyboyzv yjhqdghvab (hfxylqfkfb, setrohtvav - jmonxuyvmo)
Phase 2
-
17-AAG
tshiqgdfwk(kybunkexbx) = oresaozyiv shgwvesdbp (zewzgtawfc )
-
01 Feb 2012
Phase 2
22
wylbifwrfp = gguiqawpke gpajbjnysz (gxqxpqmdex, tnimpxxrym - fvukcbishe)
-
30 May 2011
Phase 1/2
72
esxupddqvr(pmfmvpprek) = 28% pwejgyhmbv (qnmgtyysjb )
-
20 May 2009
Phase 2
29
nyhcumjpop(qhfenntzkt) = lsfgdpvtlf yyexfttcna (songknzhwl )
Positive
20 May 2008
Phase 2
14
rvisefklxi(bfqgjqwhaz) = jgttwyhrrk nrosigmjzv (itiwxnocwi )
-
20 Jun 2007
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Clinical Trial

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Approval

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Regulation

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