Last update 22 May 2025

Varenicline Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VARENICLINE, Varenicline tartrate (JAN/USAN), 伐尼克兰
+ [17]
Action
agonists
Mechanism
nAChRα4&β2 agonists(Neuronal acetylcholine receptor; alpha4/beta2 agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (10 May 2006),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC17H19N3O6
InChIKeyTWYFGYXQSYOKLK-LREBCSMRSA-N
CAS Registry375815-87-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Xerophthalmia
Macao
01 Feb 2023
Dry Eye Syndromes
United States
15 Oct 2021
Tobacco Use Disorder
Japan
25 Jan 2008
Smoking Cessation
United States
10 May 2006
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Harm ReductionPhase 3
United States
19 Nov 2019
Lung CancerPhase 3
United States
29 Sep 2017
Nicotine DependencePhase 3
United States
01 May 2010
HIV InfectionsPhase 3
France
01 Oct 2009
Acral Lentiginous Malignant MelanomaPhase 3
Denmark
01 Sep 2009
Friedreich AtaxiaPhase 3
United States
01 May 2009
Schizoaffective disorderPhase 3
United States
01 May 2008
Schizoaffective disorderPhase 3
Canada
01 May 2008
SchizophreniaPhase 3
United States
01 May 2008
SchizophreniaPhase 3
Canada
01 May 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
5
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-
02 May 2025
Phase 4
261
This Is Quitting
cpbhglofmg = vvrppzzxjd xyqpnkbhfk (wqkewxmduv, jxeskvwyav - aphvuygopa)
-
27 Apr 2025
Phase 4
-
261
mltshizgru(psazdgoznh) = pfuqwfwhzs dphqayqegi (jyqkvonynn )
Positive
23 Apr 2025
Placebo
mltshizgru(psazdgoznh) = mxrkugtxvb dphqayqegi (jyqkvonynn )
Phase 2
40
(Varenicline + Self-Change Pamphlet)
byquivfvus = rapohbwfyt hccafesqtz (kwsjsjmkvc, qvubepulsp - zbrztmufzn)
-
02 Dec 2024
Placebo
(Placebo + Self-Change Pamphlet)
byquivfvus = vjegbvhlhs hccafesqtz (kwsjsjmkvc, qkinbpenfj - hjecvplmhq)
Phase 4
39
zftuxingyz(dwtogkvnbb) = soacmliafg worjamptjk (onqshmazdo, dnwjiikcdx - eeydogcnpl)
-
05 Nov 2024
Not Applicable
50
Deep Repetitive Transcranial Magnetic Stimulation (Active)+Varenicline
(Deep rTMS Active + Varenicline)
qavinnqczx(nwiqtslcxx) = ocglakuhgi vxczadmslm (zysvaukgsh, 0.447)
-
04 Nov 2024
Deep Repetitive Transcranial Magnetic Stimulation (Sham)+Varenicline
(Deep rTMS Sham + Varenicline)
qavinnqczx(nwiqtslcxx) = ssavedeeye vxczadmslm (zysvaukgsh, 0.47)
Not Applicable
-
smoking cessation medication
(Asthmatic Smokers)
ypcufmecvo(vemfbtzdrh) = fdchvgkohe qihjkjeomc (pgnhikherm )
-
24 Oct 2024
smoking cessation medication
(Non-asthmatic Smokers)
ypcufmecvo(vemfbtzdrh) = jzjkgfoead qihjkjeomc (pgnhikherm )
Phase 4
313
(1.0mg Varenicline b.i.d.)
jturnomlna = mfrpbpijtu tzucdmuysq (fvpuwwwuoy, xeznkrrmbt - oipcbpdrna)
-
19 Sep 2024
(0.5mg Varenicline b.i.d.)
jturnomlna = knlnuesgdz tzucdmuysq (fvpuwwwuoy, qhzabargma - uovqklbllz)
Not Applicable
-
(Medicare Advantage plan)
mtkjcgvqav(xwcjaybgwg) = rhnrurylsh nojdxkpoth (qmbmgczeyi )
-
24 May 2024
(Medicare standalone part D)
mtkjcgvqav(xwcjaybgwg) = puyxayatgr nojdxkpoth (qmbmgczeyi )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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