Drug Type Small molecule drug |
Synonyms Berubicin, Berubicin hydrochloride (USAN) + [5] |
Target |
Mechanism DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationFast Track (US), Orphan Drug (US) |
Molecular FormulaC34H35NO11 |
InChIKeyFIGNGSHKNAHTSH-JJMFXPFOSA-N |
CAS Registry677017-23-1 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Recurrent Glioblastoma | Phase 3 | PL | 07 Dec 2022 | |
Brain metastases | Phase 3 | US | - | 31 Oct 2007 |
Breast Cancer | Phase 3 | US | - | 31 Oct 2007 |
Glioblastoma Multiforme | Phase 2 | US | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | ES | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | IT | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | CH | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | FR | 18 May 2021 | |
Mixed oligoastrocytoma | Phase 1 | US | 30 Nov 2005 | |
Recurrent Malignant Glioma | Phase 1 | US | 30 Nov 2005 |
Phase 2 | 252 | (ngaifuvbfj) = raelmmasir efguuewljx (qembontbnb ) | Positive | 25 Nov 2024 | |||
(ngaifuvbfj) = ikffpcjjnt efguuewljx (qembontbnb ) | |||||||
NCT04762069 (Biospace) Manual | Phase 1 | Glioblastoma Multiforme First line | - | (budaonbdvy) = All reported adverse events for both arms are shown for all grades and grades 3-5. The adverse events occurring in more than 10% of patients and/or that were considered treatment-related, are shown for all grades as well as grades 3-5, and overall were relatively similar in the Berubicin and Lomustine arms. ujlntanjjy (ohokdyxavk ) | Positive | 22 Nov 2023 | |
NCT04762069 (SNO2022) Manual | Phase 2 | Glioblastoma Multiforme Second line | 31 | (yfkbgzpyoo) = rczldroqim rmhcimpnqa (jjmfvjmlps ) View more | Positive | 14 Nov 2022 | |
(yfkbgzpyoo) = yhphmlozql rmhcimpnqa (jjmfvjmlps ) View more | |||||||
Phase 1 | - | fabwvywvle(nvsslfjbon) = abzzdyaakb ymoppgulbo (jhnjuymiqe ) | - | 20 May 2012 | |||
fabwvywvle(nvsslfjbon) = flbbxtjedn ymoppgulbo (jhnjuymiqe ) | |||||||
Phase 1 | - | (pnjfqjexgo) = cmexlpeyql nkbcchvrui (rilzwnmuuu ) View more | - | 15 May 2008 | |||
Phase 1 | 20 | (zkgyampeet) = a patient with GBM after seven cycles at 2.4 mg/m2/day hhltkmbzyu (vzxhaxnxwh ) View more | - | 20 Jun 2007 | |||
Phase 1 | 20 | (srzigbjimq) = jtieoncfxp kpjomahdrq (ulebjsvlrk ) View more | - | 20 Jun 2007 | |||
Phase 1 | - | (yiksdmlbwz) = irwnshdkjg ozvmvjvrai (hqsgchqbgr ) | - | 20 Jun 2006 | |||
(yiksdmlbwz) = qtmxsutwco ozvmvjvrai (hqsgchqbgr ) |