Last update 01 Nov 2024

Berubicin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Berubicin, Berubicin hydrochloride (USAN)
+ [5]
Mechanism
DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC34H36ClNO11
InChIKeyGPMIHHFZKBVWAZ-LMMKTYIZSA-N
CAS Registry293736-67-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D08871--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Brain metastasesPhase 3
US
-31 Oct 2007
Breast CancerPhase 3
US
-31 Oct 2007
Glioblastoma MultiformePhase 2
US
18 May 2021
Glioblastoma MultiformePhase 2
ES
18 May 2021
Glioblastoma MultiformePhase 2
CH
18 May 2021
Glioblastoma MultiformePhase 2
IT
18 May 2021
Glioblastoma MultiformePhase 2
FR
18 May 2021
Recurrent GlioblastomaPhase 1
PL
07 Dec 2022
Brain CancerPhase 1
US
01 Sep 2006
LymphomaPreclinical
US
01 Sep 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
(carwsewawp) = All reported adverse events for both arms are shown for all grades and grades 3-5. The adverse events occurring in more than 10% of patients and/or that were considered treatment-related, are shown for all grades as well as grades 3-5, and overall were relatively similar in the Berubicin and Lomustine arms. kbtqhqzkyk (dfxcennhxl )
Positive
22 Nov 2023
Phase 2
31
(argfeuwfsu) = czrrspvqga dswuosysuq (fkapuhrbsm )
Positive
14 Nov 2022
(argfeuwfsu) = gzomqyoczu dswuosysuq (fkapuhrbsm )
Phase 1
-
atruhlmllm(jrvzlfjkcb) = lagokjxxpj iqoguwhomy (yeuknctocu )
-
20 May 2012
atruhlmllm(jrvzlfjkcb) = wnidvkztpp iqoguwhomy (yeuknctocu )
Phase 1
-
(xtkrbafbwp) = zmbkcmdizc umjyyrepjj (kebrhokaau )
-
15 May 2008
Phase 1
20
(veuiegmvpl) = a patient with GBM after seven cycles at 2.4 mg/m2/day deazihalgt (ybevhaazct )
-
20 Jun 2007
Phase 1
20
(imgrjqenek) = ptossxvyut aaybrkauut (dykodxnsca )
-
20 Jun 2007
Phase 1
-
(ntasholqic) = mvkqijaums aplalqqqve (kxzgszwskw )
-
20 Jun 2006
(ntasholqic) = ulsaxlgtin aplalqqqve (kxzgszwskw )
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Regulation

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