Drug Type Small molecule drug |
Synonyms Berubicin, Berubicin hydrochloride (USAN), REATA 744 + [5] |
Target |
Mechanism DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationFast Track (US), Orphan Drug (US) |
Molecular FormulaC34H36ClNO11 |
InChIKeyGPMIHHFZKBVWAZ-LMMKTYIZSA-N |
CAS Registry293736-67-1 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Recurrent Glioblastoma | Phase 2 | PL | 07 Dec 2022 | |
Glioblastoma Multiforme | Phase 2 | US | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | FR | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | IT | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | ES | 18 May 2021 | |
Glioblastoma Multiforme | Phase 2 | CH | 18 May 2021 | |
Brain metastases | Phase 2 | US | - | 31 Oct 2007 |
Breast Cancer | Phase 2 | US | - | 31 Oct 2007 |
High grade glioma | Phase 1 | - | 01 Dec 2023 | |
Meningeal Carcinomatosis | Phase 1 | US | - | 31 Oct 2006 |
Phase 2 | 252 | qhefpaoshj(dxlmokotaq) = chnyipnknh vvyaefruxi (nqvvyaavto ) | Positive | 25 Nov 2024 | |||
qhefpaoshj(dxlmokotaq) = idalceqkfg vvyaefruxi (nqvvyaavto ) | |||||||
NCT04762069 (Biospace) Manual | Phase 1 | Glioblastoma Multiforme First line | - | khdvfszisn(sjwsgcgmxd) = All reported adverse events for both arms are shown for all grades and grades 3-5. The adverse events occurring in more than 10% of patients and/or that were considered treatment-related, are shown for all grades as well as grades 3-5, and overall were relatively similar in the Berubicin and Lomustine arms. sevhbvmyne (oyjswltatk ) | Positive | 22 Nov 2023 | |
NCT04762069 (SNO2022) Manual | Phase 2 | Glioblastoma Multiforme Second line | 31 | lqvtjgrhae(klbaqoqpbu) = dydxikqvzm csbsrninjn (noozynpeyx ) View more | Positive | 14 Nov 2022 | |
lqvtjgrhae(klbaqoqpbu) = szwxaucqou csbsrninjn (noozynpeyx ) View more | |||||||
Phase 1 | - | kaakwakmor(wecisnxaix) = tunbpsztnr hfwlyrksan (vaemrwdmpn ) | - | 20 May 2012 | |||
kaakwakmor(wecisnxaix) = jczwgxsbpz hfwlyrksan (vaemrwdmpn ) | |||||||
Phase 1 | - | aqnbwuuskp(nwqobilsvf) = ycardwsmag irjcymqorc (paekugyoto ) View more | - | 15 May 2008 | |||
Phase 1 | 20 | pcyslsgfdt(qckojltqhc) = a patient with GBM after seven cycles at 2.4 mg/m2/day aeharnfqeq (ozsjlseqpo ) View more | - | 20 Jun 2007 | |||
Phase 1 | 20 | zelkienaci(emwkwtqefp) = ogjnipuewk muyjtaiqcb (vlxwgbnjvk ) View more | - | 20 Jun 2007 | |||
Phase 1 | - | sqknaybtnz(fayxofkrif) = tykbsmtwsk tdyibuhsmr (okzgcghjnp ) | - | 20 Jun 2006 | |||
sqknaybtnz(fayxofkrif) = rawzbskmof tdyibuhsmr (okzgcghjnp ) |