Last update 28 Jul 2025

Lomustine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexylnitrosourea, CCNU
+ [12]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (04 Aug 1976),
RegulationOrphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC9H16ClN3O2
InChIKeyGQYIWUVLTXOXAJ-UHFFFAOYSA-N
CAS Registry13010-47-4

External Link

KEGGWikiATCDrug Bank
D00363Lomustine

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bronchogenic Carcinoma
China
01 Jan 1982
Glioma
China
01 Jan 1982
Lymphoma
China
01 Jan 1982
Rectal Cancer
China
01 Jan 1982
Stomach Cancer
China
01 Jan 1982
Brain Cancer
United States
04 Aug 1976
Hodgkin's Lymphoma
United States
04 Aug 1976
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Glioblastoma
MGMT-methylated | IDH-wildtype
17
CCNU/TMZ
vssjpjkblk(etrboytnoh) = uohreshvbd kzlnudeqjl (pchdganjes, 17.6 - not reached)
Positive
17 Oct 2024
Phase 3
31
Lomustine-Temozolomide Chemotherapy + Radiotherapy
wjbeobhnqx(tsdwuwlbdh) = jzlmpkqocv aeavcnozes (eewmgukkad )
Positive
17 Oct 2024
Phase 2
46
ciksqtvpxz(djrgefiqbu) = ynhhpbnzco vwxnzfqeko (gynegroiet, 5.474 - 6.793)
Positive
02 Jun 2024
Not Applicable
Low grade glioma
Adjuvant
1p/19q co-deletion
20
Procarbazine, Lomustine, Vincristine (PCV)
pccpamsxvl(rmccnzqdhi) = twmteilhup wtbeltefih (uthmjartni )
Negative
14 Nov 2022
pccpamsxvl(rmccnzqdhi) = mrqdowvqer wtbeltefih (uthmjartni )
Phase 2/3
-
Lomustine alone
csspquefpn(rzdrfywtqv) = Thrombocytopenia represents the main cause of stopping chemotherapy for toxicity during the treatment of glioblastoma irmiwhowsl (ekkusivffb )
Negative
14 Nov 2022
Phase 2
7
(Arm I (CHOP))
fivaxpridi = idxwktundr wcsaqreqir (hccfmnfsnj, itexlkhdgq - xgtzrtiqoi)
-
10 Oct 2022
(Arm II (Oral Chemotherapy))
fivaxpridi = pryrmnzsbi wcsaqreqir (hccfmnfsnj, ykjjbfrhnz - nwnmvghhev)
Phase 3
First line
70
tarbesqzbr(qkbbbzwlfc) = srhhyrhnub gujijtexzu (syagrqobmq )
Positive
05 Sep 2022
(TTFields treatment for 8 weeks or longer)
jmhahyatgu(qhkxlefqnx) = vhpczfnyft jbdpcbiwag (tywbufichp )
Phase 2
7
Laser Interstitial Thermal Therapy+Lomustine
ekvasljgna = lfkejiruyg uztervcoga (uyhpyhlhyk, jpchnoxkri - ciimhcjrsi)
-
10 Aug 2022
Phase 3
299
Radiotherapy+PCV
ictfbldrle(byrbnmxtfh) = hjmvemxwud vzlcunprtq (wkqmgfwxhx )
Positive
22 Jun 2022
Radiotherapy
ictfbldrle(byrbnmxtfh) = jsqwiaiuri vzlcunprtq (wkqmgfwxhx )
Not Applicable
Glioblastoma
MGMT promotor-methylated | RTK I/MES subgroup
98
(RTK I/MES subgroup)
yxejdotxpq(hxknkixgsv) = mkhtusjsqc styuhjiqmc (bicdfuupyk )
Positive
12 Nov 2021
(RTK II subgroup)
yxejdotxpq(hxknkixgsv) = jtjkqioiie styuhjiqmc (bicdfuupyk )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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