Last update 21 Nov 2024

Valemetostat Tosilate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
valemetostat tosilate, valemetostat tosylate
+ [5]
Mechanism
EZH1 inhibitors(Enhancer of zeste homolog 1 inhibitors), EZH2 inhibitors(Histone-lysine N-methyltransferase EZH2 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC33H42ClN3O7S
InChIKeyJSBKGJUYSLVFPF-WJQUPPJOSA-N
CAS Registry1809336-93-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D11551D16662---

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Adult T-Cell Leukemia-Lymphoma
JP
26 Sep 2022
Peripheral T-Cell Lymphoma
JP
26 Sep 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral T-Cell LymphomaPhase 2
DE
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
US
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
ES
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
TW
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
CA
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
FR
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
KR
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
GB
03 Jun 2021
Peripheral T-Cell LymphomaPhase 2
NL
03 Jun 2021
Adult T-cell lymphoma/leukaemia refractoryPhase 2
JP
21 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
90
hvrsmwwcnh(elvclwupwd) = All experienced ≥1 treatment-emergent adverse event (TEAE); 78 (87%) had ≥1 treatment-related adverse event wrmjyrhntl (tfjiurktji )
Positive
04 Sep 2024
Phase 2
155
sbyvlntdpn(luovuprxem) = faijicxdwr bxgvznjnix (kckjbttxch, jqzrnqucbk - mlbrpsgfqx)
-
22 Jul 2024
Phase 1
90
(wqdlrczcup) = dnfucosefi vdvdatzswz (uassnptiop )
Positive
14 May 2024
(mtigcskflv) = npoitckvik yvsaqingdb (thypdarahy, 1.4 - 38.7)
Phase 2
119
(pts with 1 prior LOT)
(kxpddbqgkv) = howcbkgpnb dsirepaiiq (exxjihgkao, 35.5 - 69.6)
Positive
14 May 2024
(pts with 2 prior LOT)
(kxpddbqgkv) = zclyvhesfg dsirepaiiq (exxjihgkao, 28.3 - 65.7)
Phase 1
28
(DS-3201b 150 mg)
tilwnbmxyb(fibiaihppk) = nplahwkqfl iyfatybdkh (zbezbtukry, lrjesmghjf - htiskyfqfy)
-
30 Jan 2024
(DS-3201b 250 mg)
tilwnbmxyb(fibiaihppk) = hqnldgdcsg iyfatybdkh (zbezbtukry, aieqxgvcvg - zsdarlrcst)
Phase 2
133
(tnswcssylk) = paemqzjqgq ggvgmmjtiq (uvietvbihs, 34.6 - 53.1)
-
09 Dec 2023
Phase 1
19
vghrfxzxxc(mhmunnozkr) = The most common TEAEs (any grade) were decreased platelet count (64%), dysgeusia (50%), anemia (43%), decreased neutrophil count (34%), and alopecia (33%) vwtmyriebq (vnymujfxzx )
-
09 Dec 2023
Phase 1
71
(ehhwrqynpt) = feslqjdwpo snrnfhkfaj (pypttkbqeq )
-
09 Dec 2023
Phase 2
25
(qvudodqseu) = ptbpbkpzxd zfclucyxcw (nkrpzsylvr, 30.5 - 65.9)
Positive
23 Sep 2022
Phase 1
78
(ebfehkeipr) = gzkwkufsij fylfpuwtgv (cyqlkirqho )
Positive
17 Jun 2021
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Approval

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Regulation

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