Delving into the Latest Updates on Atorvastatin strontium with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms

Atorvastatin, 阿托伐他汀, Newvast

Target

HMGCR

Action

inhibitors

Mechanism

HMG-CoA reductase inhibitors(HMG-CoA reductase inhibitors)

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Hyperlipidemias

Inactive Indication-

Originator Organization

Hanmi Pharmaceutical Co., Ltd.

Active Organization

Hanmi Pharmaceutical Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

South Korea (28 Nov 2008),

Hyperlipidemias

Regulation-

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Structure/Sequence

Molecular FormulaC66H70F2N4O10Sr

InChIKeyDTKMQPSVRFQLOA-MNSAWQCASA-N

CAS Registry1072903-92-4

Two Dutch guidelines (Stroke and Cardiovascular Risk Management) provide conflicting advice on optimal statin treatment in older patients. In the SAFEST - RCT, the investigators will assess the impact of starting versus not starting a statin in frail individuals aged 70 and above with a recent ischemic stroke or transient ischemic attack (TIA) on their health-related quality of life and Major Adverse Cardiovascular Events (MACE) free survival during a two-year follow-up period.

Start Date01 Feb 2025

Sponsor / Collaborator

University of Amsterdam

TCTR20241030002

/ Not yet recruitingPhase 1IIT

Bioequivalence study of a randomized, open-label, single oral dose, 4-period, 2-treatment, 2-sequence, full replicate, crossover study of Atorvastatin 80 mg tablets relative to Lipitor 80 mg tablets in healthy Thai volunteers under fasting condition

Start Date13 Jan 2025

Sponsor / Collaborator

Bio-innova Co., Ltd

IRCT20240807062680N1

/ CompletedNot ApplicableIIT

Dose-Dependent Anti-Inflammatory Effects of Atorvastatin as Adjunctive Therapy for Seizure Control in Drug-Resistant Epilepsy

Start Date23 Dec 2024

Sponsor / Collaborator

Tehran University of Medical Sciences

100 Clinical Results associated with Atorvastatin strontium

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100 Translational Medicine associated with Atorvastatin strontium

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100 Patents (Medical) associated with Atorvastatin strontium

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13,145

Literatures (Medical) associated with Atorvastatin strontium

01 Feb 2026·TISSUE & CELL

Atorvastatin ameliorates cerebral cortical pathological and cognitive alterations in aged rats: Histological & immunohistochemical study

Article

Author: Ibrahim, Ateya M ; Elsherbiny, Nehal M ; Elshafey, Mohamed ; El-Sherbiny, Mohamed ; Ebrahim, Hasnaa Ali ; Mostafa, Hany K K ; Elsherbini, Dalia Mahmoud Abdelmonem ; Safwat, Marwa Mohamed ; El Hasnaoui-Saadani, Raja ; El-Agawy, Mosaab Salah El-Din ; Abomosallam, Mohamed ; Ali, Zeinab A ; Ali, Ehab Kamal

Aging is an important risk factor for neurodegenerative disease and requires the development of safe and widely accessible strategies to mitigate brain aging. Atorvastatin, primarily recognized for its cholesterol-lowering properties, has largely unexplored potential in modulating autophagy and safeguarding against age-related cognitive decline. The current study aimed to explore the potential beneficial impact of atorvastatin on structural and functional brain alterations in aged rats by analyzing its influence on autophagy and related processes, including apoptosis, inflammation, and oxidative stress. The study involved twenty-four rats, which were separated into three distinct groups: the adult control group (3-4 months old), the untreated aged group (20-24 months old) that received saline orally, and the aged treated group (20-24 months old) that received atorvastatin orally for 30 days at a dose of 20 mg/kg. Memory performance was evaluated using behavioural assessments. The cortical levels of oxidative stress markers, namely Nrf-2, MDA, GSH, and SOD, along with inflammatory mediators such as TNF-α and IL-1β, were quantified. Histopathological changes and immune staining of NF-κB, Nrf-2, TNF-α, Anti-SQSTM1/p62, LC3, and CD68 were evaluated. Furthermore, the levels of p62, caspase-3, and SIRT1 expression were determined. Atorvastatin enhanced memory function in aged rats. This was achieved by restoring the oxidative-antioxidant balance in the cortex, as evidenced by increased levels of Nrf-2, GSH, and SOD, along with a reduction in MDA levels. TNF-α, IL-6, and NF-κB cortical expression was suppressed, indicating their anti-inflammatory effects. Furthermore, autophagy was enhanced, as shown by elevated LC3 and decreased p62 expression, whereas apoptosis was mitigated through the downregulation of Caspase-3. Histological analysis corroborated the preservation of cortical structure and protection against neurodegenerative changes associated with aging. In conclusion, atorvastatin showed neuroprotective impact in this aged rat model by reducing oxidative stress, inflammation, and apoptosis, while modulating autophagy markers. These preclinical findings warrant further investigation, including clinical studies, to evaluate their therapeutic potential in humans.

31 Dec 2025·Pulmonology

Early effects of acetazolamide on hemoglobin mass and plasma volume in chronic mountain sickness at 5100 m

Article

Author: Salazar-Granara, A.A. ; Doutreleau, S. ; Verges, S. ; Pina, A. ; Guergour, D. ; Connes, P. ; Pichon, A. ; Hancco, I. ; Champigneulle, B. ; Howe, C.A. ; Robach, P. ; Stauffer, E. ; Brugniaux, J.V.

INTRODUCTION AND OBJECTIVES:

Chronic Mountain Sickness (CMS) syndrome, combining excessive erythrocytosis and clinical symptoms in highlanders, remains a public health concern in high-altitude areas, especially in the Andes, with limited therapeutic approaches. The objectives of this study were to assess in CMS-highlanders permanently living in La Rinconada (5100-5300 m, Peru, the highest city in the world), the early efficacy of acetazolamide (ACZ) and atorvastatin to reduce hematocrit (Hct), as well as the underlying mechanisms focusing on intravascular volumes.

MATERIALS AND METHODS:

Forty-one males (46±8 years of age) permanently living in La Rinconada for 15 [10-20] years and suffering from CMS were randomized between ACZ (250 mg once-daily; N = 13), atorvastatin (20 mg once-daily; N = 14) or placebo (N = 14) uptake in a double-blinded parallel study. Hematocrit (primary endpoint) as well as arterial blood gasses, total hemoglobin mass (Hb_mass) and intravascular volumes were assessed at baseline and after a mean (±SD) treatment duration of 19±2 days.

RESULTS:

ACZ increased PaO₂ by +13.4% (95% CI: 4.3 to 22.5%) and decreased Hct by -5.2% (95% CI: -8.3 to -2.2%), whereas Hct remained unchanged with placebo or atorvastatin. ACZ tended to decrease Hb_mass (-2.6%, 95% CI: -5.7 to 0.5%), decreased total red blood cell volume (RBCV, -5.3%, 95% CI: -10.3 to -0.3%) and increased plasma volume (PV, +17.6%, 95% CI: 4.9 to 30.3%). Atorvastatin had no effect on intravascular volumes, while Hb_mass and RBCV increased in the placebo group (+6.1%, 95% CI: 4.2 to 7.9% and +7.0%, 95%CI: 2.7 to 11.4%, respectively).

CONCLUSIONS:

Short-term ACZ uptake was effective to reduce Hct in CMS-highlanders living at extreme altitude >5,000 m and was associated with both an increase in PV and a reduction in RBCV.

31 Dec 2025·Virulence

Disruption of CmHmgr1 triggers apoptosis and causes defects in growth, conidiogenesis, and mycoparasitism of Coniothyrium minitans

Article

Author: Hu, Zijin ; Yang, Xiaoxiang ; Zhang, Zhongmei ; Wang, Haixuan ; Jiang, Daohong ; Zhang, Lei ; Fu, Yanping

Coniothyrium minitans is a well-known mycoparasite against Sclerotinia sclerotiorum. Two critical factors for the commercialization of C. minitans as a biocontrol agent are conidial production and parasitism. To decipher the mechanisms of conidiogenesis and mycoparasitism in C. minitans, a conidiation-deficient mutant, ZS-1TN5012, was isolated from a transfer DNA (T-DNA) insertional library. This mutant exhibited significantly reduced hyphal development, poor conidiation, and decreased sclerotial mycoparasitism. CmHmgr1 encoding a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) was disrupted by the T-DNA insertion. The colony morphology of the wild-type strain ZS-1 resembled that of the mutant ZS-1TN5012 when the HMGR inhibitor atorvastatin was added to potato dextrose agar, with the mutant showing more sensitivity to atorvastatin. Furthermore, cellular localization assays revealed that CmHmgr1 was localized in mitochondria. Gene replacement and complementation experiments confirmed that CmHmgr1 is involved in the growth, conidiogenesis and mycoparasitism of C. minitans, and disruption of CmHmgr1 triggers apoptosis.

12

News (Medical) associated with Atorvastatin strontium

04 Aug 2025

·pharma.economictimes.indiatimes.com

NPPA sets retail prices of 37 drugs; notifies 4 scheduled formulations ceiling price

New Delhi: India’s drug price controller, NPPA has fixed the retail prices of 37 new drug including key type-2 diabetes formulations, antibiotics, cardiac therapies among several others. Issuing a gazette notification, the National Pharmaceutical Pricing Authority (NPPA) announced that the based on the decision of the 135th Authority meeting, the body has fixed retail prices of 37 formulations under Drugs (Prices Control) Order, 2013.” The notified list of 37 formulations includes key diabetes formulations of Empagliflozin, Sitagliptin, Meformin and Linagliptin. Additionally the list comprises formulation of Atorvastatin & Ezetimibe indicated for the treatment of high cholesterol and fats. The list further lunches other common anti-inflammatory formulations and drugs like Paracetamol, Diclofenac among several others. Under the Drugs Price Control Order any marketer, or manufacturers that intends to market a new drug in India is required to obtain a prior approval of the particular drug retail price from the NPPA and in case the fixed price is not complied, then the concerned manufacturer/marketing company is required to deposit the overcharged amount along with an interests per the relevant provision. However, the fixed retail prices are applicable only to the individual manufacturer / marketer who have applied for the same and are specified in the mentioned in the notified list. Meanwhile, in a separate gazette notification the national drug price controller has fixed the ceiling price of four scheduled formulations. The latest notified list includes Ipratropium, Sodium nitroprusside, Povidone iodine, and Diltiazem. Ipratropium is a ‘respirator solution’ indicated for the treatment of condictions like COPD and the drug ceiling price is capped at ₹2.96 per unit. Sodium nitroprusside is an injectable used to control high blood pressure and ceiling price of the formulation is fixed at ₹28.99. The other two scheduled formulations Povidone iodine and Diltiazem are used to treat skin infections and angina (severe chest pain), and the their ceiling price is fixed at ₹6.26 per ml and ₹26.72 per capsule respectively. According to the Ministry of Health and Family Welfare , the National list of Essential Medicines includes those formulations which are indicated for the treatment of diseases which is a public health problem in India, recommended under National Health Programs of India and several other factors. The prices of drugs categorised in the list are fixed and maintained by the NPPA to ensure the affordability of essential drugs for consumers and currently the list includes over 900 formulations. By Online Bureau ,

NDA

04 Aug 2025

·pharma.economictimes.indiatimes.com

NPPA sets retail prices of 37 drugs; notifies 4 scheduled formulations ceiling price

New Delhi: India’s drug price controller, NPPA has fixed the retail prices of 37 new drug including key type-2 diabetes formulations, antibiotics, cardiac therapies among several others. Issuing a gazette notification, the National Pharmaceutical Pricing Authority (NPPA) announced that the based on the decision of the 135th Authority meeting, the body has fixed retail prices of 37 formulations under Drugs (Prices Control) Order, 2013.” The notified list of 37 formulations includes key diabetes formulations of Empagliflozin, Sitagliptin, Meformin and Linagliptin. Additionally the list comprises formulation of Atorvastatin & Ezetimibe indicated for the treatment of high cholesterol and fats. The list further lunches other common anti-inflammatory formulations and drugs like Paracetamol, Diclofenac among several others. Under the Drugs Price Control Order any marketer, or manufacturers that intends to market a new drug in India is required to obtain a prior approval of the particular drug retail price from the NPPA and in case the fixed price is not complied, then the concerned manufacturer/marketing company is required to deposit the overcharged amount along with an interests per the relevant provision. However, the fixed retail prices are applicable only to the individual manufacturer / marketer who have applied for the same and are specified in the mentioned in the notified list. Meanwhile, in a separate gazette notification the national drug price controller has fixed the ceiling price of four scheduled formulations. The latest notified list includes Ipratropium, Sodium nitroprusside, Povidone iodine, and Diltiazem. Ipratropium is a ‘respirator solution’ indicated for the treatment of condictions like COPD and the drug ceiling price is capped at ₹2.96 per unit. Sodium nitroprusside is an injectable used to control high blood pressure and ceiling price of the formulation is fixed at ₹28.99. The other two scheduled formulations Povidone iodine and Diltiazem are used to treat skin infections and angina (severe chest pain), and the their ceiling price is fixed at ₹6.26 per ml and ₹26.72 per capsule respectively. According to the Ministry of Health and Family Welfare , the National list of Essential Medicines includes those formulations which are indicated for the treatment of diseases which is a public health problem in India, recommended under National Health Programs of India and several other factors. The prices of drugs categorised in the list are fixed and maintained by the NPPA to ensure the affordability of essential drugs for consumers and currently the list includes over 900 formulations. By Online Bureau ,

NDA

23 May 2025

·pharma.economictimes.indiatimes.com

Alembic secures USFDA nod for Amlodipine and Atorvastatin Tablets

Mumbai: Alembic Pharmaceuticals Limited today announced it has received final approval from the United States Food and Drug Administration (USFDA) for its Abbreviated New Drug Application (ANDA) for Amlodipine and Atorvastatin Tablets USP, in multiple strengths. The approved product is therapeutically equivalent to Pharmacia and Upjohn Co. LLC’s reference-listed drug (RLD), Caduet Tablets . The drug, available in strengths ranging from 2.5 mg/10 mg to 10 mg/80 mg, are indicated in patients for whom treatment with both amlodipine and atorvastatin is appropriate. With this approval, Alembic now has a cumulative total of 223 ANDA approvals from the USFDA, comprising 199 final approvals and 24 tentative approvals. By Online Bureau ,

Drug ApprovalNDA

100 Deals associated with Atorvastatin strontium

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Atorvastatin strontium	C10BA05	DB01076

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hyperlipidemias	South Korea	Hanmi Pharmaceutical Co., Ltd.	28 Nov 2008

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


23-PUB (ADA2024)	Phase 3	Diabetes Mellitus, Type 2 \| Dyslipidemias	65	Atorvastatin/Fenofibrate 20 mg/160 mg	utopodqccx(kwkuxnxvpq) = iclorjrpqo wfvyuhaubf (mlsafemhhk, 145.3)	Positive	14 Jun 2024
				Atorvastatin 20 mg	utopodqccx(kwkuxnxvpq) = jtzhfqozbd wfvyuhaubf (mlsafemhhk, 75.7)
ADA2024	Not Applicable	Angina Pectoris	-	High-intensity Atorvastatin	jkjxsaksjs(qfgpdksxxq): aHR = 0.82 (95% CI, 0.67 - 1.01), P-Value = 0.066 View more	-	14 Jun 2024
				Moderate-intensity Atorvastatin + Ezetimibe
NCT01341730 (PIONEER, CTgov)	Phase 4	Coronary Artery Disease \| Angina, Unstable \| Carotid Artery Diseases ... View more	41	Atorvastatin 20mg (Atorvastatin 20 mg)	zkqspzuyft(dbczkbxiwt) = mozaduafix cpptmvukzp (oedpldvoof, 0.04) View more	-	06 Aug 2020
				Pioglitazone+Atorvastatin (Atorvastatin 20 mg + Pioglitazone 30 mg)	zkqspzuyft(dbczkbxiwt) = xmexdldjlc cpptmvukzp (oedpldvoof, 0.07) View more
NCT00435045 (CTgov)	Phase 3	Hypertriglyceridemia	245	Atorvastatin+Lovaza(Omacor) (Lovaza(Omacor) + Atorvastatin)	eiskqsnmej(yyiuywtoux) = qzocaoxaqo veslhmzixj (wdvgcgohrw, dpaqaeoyzs - kdrdkmmlwu) View more	-	12 May 2009
				Placebo+Atorvastatin (Placebo + Atorvastatin)	eiskqsnmej(yyiuywtoux) = xzenapjkiq veslhmzixj (wdvgcgohrw, psijaxesah - jbahwuqxiq) View more