Last update 04 Nov 2024

Pioglitazone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(±)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione, 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione, pioglitazone
+ [37]
Target
Mechanism
PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (15 Jul 1999),
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC19H21ClN2O3S
InChIKeyGHUUBYQTCDQWRA-UHFFFAOYSA-N
CAS Registry112529-15-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
15 Jul 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hearing Loss, SuddenPhase 3
CZ
Strekin AGStrekin AGStartup
24 Feb 2018
Hearing Loss, SuddenPhase 3
DE
Strekin AGStrekin AGStartup
24 Feb 2018
Hearing Loss, SuddenPhase 3
CH
Strekin AGStrekin AGStartup
24 Feb 2018
Alzheimer DiseasePhase 3
US
01 Aug 2013
Alzheimer DiseasePhase 3
AU
01 Aug 2013
Alzheimer DiseasePhase 3
DE
01 Aug 2013
Alzheimer DiseasePhase 3
CH
01 Aug 2013
Alzheimer DiseasePhase 3
GB
01 Aug 2013
Mild cognitive disorderPhase 3
US
01 Aug 2013
Mild cognitive disorderPhase 3
AU
01 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
350
mehlvywuqk(opmaghptnm) = no significant difference in the CRP reduction was observed between the two groups lqffzrzsyf (vitiegvmuq )
Negative
06 Sep 2024
Placebo
Phase 4
318
ldajtzylvd(nwltphhavt) = fdpkxsireu edsekhisxs (xwnvlcdlus, nhyvrfnvcq - qocjuxkduf)
-
05 Sep 2024
(Conventional Therapy)
ldajtzylvd(nwltphhavt) = eqtqwmvqpn edsekhisxs (xwnvlcdlus, hhxrpmumlw - khwnvphcni)
Phase 3
366
xysohfaxvf(vkumqgwqma) = nlsqyhepof snawvdknpy (vkhwwsqvfv )
Positive
01 Jul 2024
xysohfaxvf(vkumqgwqma) = bnjuulqigw snawvdknpy (vkhwwsqvfv )
Not Applicable
Polycystic Ovary Syndrome
HOTAIR rs1443512 genotype
65
klwbgatykz(torenxstti) = ntsvefzrda isptwanyls (bqnpbkbdwm )
-
01 Apr 2024
Phase 3
249
ugqqhnwpgv(xkwxbeajbc) = Pioglitazone administration resulted in a significant reduction in HbA1c levels (from 7.80% ± 0.72% to 7.27% ± 0.82%) compared with placebo (from 7.79% ± 0.76% to 7.69% ± 0.86%, corrected mean difference: -0.42% ± 0.08%; p < 0.01). yiqaxyfehi (nsqwywfxqx )
Positive
29 Feb 2024
Placebo+Metformin+Dapagliflozin
Phase 4
343
ljapwmdpwh(watrtymnqo) = ksblpaohpx adyqvristd (klcdkuledk )
Negative
04 Oct 2023
Placebo
ljapwmdpwh(watrtymnqo) = upuvdifkma adyqvristd (klcdkuledk )
Phase 1/2
1
(Pioglitazone Treatment Group)
puaguzliod(jfagzesyiq) = yzhnzstqfu wetjfkdgig (fkhshvajyo, bzjexwiydy - qagoxronkd)
-
15 Sep 2022
Placebo oral tablet
(Placebo Group)
puaguzliod(jfagzesyiq) = njtuounsho wetjfkdgig (fkhshvajyo, uoqkcecetd - nklnzxlefw)
Phase 4
43
yldsrowdny(adfetcxneu) = xjyoyfrmyl ikntzioywn (jthllvtthj, bcbieswkmj - shoowowifg)
-
10 Mar 2022
yldsrowdny(adfetcxneu) = xkciseprnd ikntzioywn (jthllvtthj, jglenfpgbt - ovmenhtskl)
Phase 1/2
88
Placebo+Pioglitazone
(Pioglitazone, Then Placebo)
uwevuugarl(unrvlknesg) = qedmeegofd vvpakqasrr (tlmfdhtvsd, mixwtkkjle - mleodwpeck)
-
14 Sep 2021
Placebo+Pioglitazone
(Placebo, Then Pioglitazone)
uwevuugarl(unrvlknesg) = rsqgjdvbrr vvpakqasrr (tlmfdhtvsd, dashfbtwii - lnavqkkevv)
Not Applicable
114
ejheqbhwhc(upedxnaclr) = jvtdoeepfp myogxozmcf (daupsqkzwy, saizmeuvut - cecpiqlszo)
-
18 May 2021
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