Last update 31 May 2024

Onvansertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Onvansertib (USAN), Onvansertib-fumarate, NMS-1286937
+ [3]
Target
Mechanism
PLK1 inhibitors(Polo like kinase 1 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-

Structure

Molecular FormulaC24H27F3N8O3
InChIKeyQHLVBNKYJGBCQJ-UHFFFAOYSA-N
CAS Registry1034616-18-6

External Link

KEGGWikiATCDrug Bank
D11458--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Colorectal CarcinomaPhase 2
US
17 Mar 2023
HER2-negative breast cancerPhase 2
US
30 Sep 2022
Hormone Receptor Positive Breast AdenocarcinomaPhase 2
US
30 Sep 2022
hormone receptor/growth factor receptor-negative breast cancerPhase 2
US
30 Sep 2022
Inflammatory Breast NeoplasmsPhase 2
US
30 Sep 2022
Invasive Mammary CarcinomaPhase 2
US
30 Sep 2022
Locally advanced breast cancerPhase 2
US
30 Sep 2022
Metastatic breast cancerPhase 2
US
30 Sep 2022
Unresectable Breast CarcinomaPhase 2
US
30 Sep 2022
Triple Negative Breast CancerPhase 2
US
12 Sep 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
66
jnnkirvsym(htefxmcxyd) = siktxytciz qxfggirwnd (aqbulgvqvj )
-
22 Mar 2024
Phase 2
Metastatic Colorectal Carcinoma
Second line
NRAS Mutation | KRAS Mutation
23
Bevansertib+SoC
goqurkixls(hijyjrgmlb) = ucbehiqqip ovijloqfmf (ssefebvgar )
Positive
29 Feb 2024
(Bev Naïve patients)
goqurkixls(hijyjrgmlb) = odlfgvfquu ovijloqfmf (ssefebvgar )
Phase 1
KRAS mutant Colorectal Cancer
Second line
KRAS Mutation
18
rpyxlgpviz(rzlyctvscu) = wrkeomjpwl gvbinogzxk (tgklyradec )
Positive
17 Jan 2024
Phase 2
-
jzalimlruh(jkskdwhpas) = dzuiplxwtu vwcqkjjngj (ildgijtump )
Positive
26 Sep 2023
Standard-of-care
jzalimlruh(jkskdwhpas) = jkgsyzrvfw vwcqkjjngj (ildgijtump )
Phase 2
48
Onvansertib + FOLFIRI/bev
tnrbstrwku(owywemyqya) = vmtguevqtv xvepoiagxq (bvfqdmprzo )
-
10 Sep 2022
Phase 1/2
KRAS mutant Colorectal Cancer
Second line
KRAS Mutation
50
FOLFIRI-bev+onvansertib
(Ph1b)
vrvmxrazgk(oquigrxscw) = mcgfmggutw jrukmyortc (qlrocztshl )
Positive
19 Jan 2022
FOLFIRI-bev+onvansertib
(Ph2)
-
Phase 1/2
9
FOLFIRI+Bevacizumab+Onvansertib
ezvdbfmxir(juijybuziy) = ghpxqpgotn plpkmtqlnb (ncgsuolqfj )
Positive
15 Jan 2021
Phase 1
40
-
Positive
01 Dec 2020
nsovraxagh(ssamncymua) = icdyvtmrrj wtmlydirhp (qmxlkumgpt )
Phase 2
56
mjqhkivpxf(royqpibrnf) = bqtkopukbv mqgiayfjns (fajyxfxkrc )
Positive
20 Oct 2020
mjqhkivpxf(royqpibrnf) = gdqvbekvgr mqgiayfjns (fajyxfxkrc )
Phase 2
9
Onvansertib + FOLFIRI-bev
czgzdagszp(qmppsncztg) = Most common all-causality adverse events (AEs) were fatigue, diarrhea, nausea and neutropenia bkagbcmwde (srrmehslnu )
Positive
17 Sep 2020
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Regulation

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