Last update 24 May 2025

Ceralasertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ATR KINASE INHIBITOR AZD6738, Ceralasertib (USAN/INN), AZD 6738
+ [2]
Target
Action
inhibitors
Mechanism
ATR inhibitors(Serine-protein kinase ATR inhibitors)
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC20H24N6O2S
InChIKeyOHUHVTCQTUDPIJ-JYCIKRDWSA-N
CAS Registry1352226-88-0

External Link

KEGGWikiATCDrug Bank
D11787--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 3
United States
18 May 2023
Non-Small Cell Lung CancerPhase 3
United States
18 May 2023
Non-Small Cell Lung CancerPhase 3
China
18 May 2023
Non-Small Cell Lung CancerPhase 3
China
18 May 2023
Non-Small Cell Lung CancerPhase 3
Japan
18 May 2023
Non-Small Cell Lung CancerPhase 3
Japan
18 May 2023
Non-Small Cell Lung CancerPhase 3
Argentina
18 May 2023
Non-Small Cell Lung CancerPhase 3
Argentina
18 May 2023
Non-Small Cell Lung CancerPhase 3
Australia
18 May 2023
Non-Small Cell Lung CancerPhase 3
Australia
18 May 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
194
oxjjsvartc = frvgxleksu lhqfjajgue (awzaaqjbgz, qnkkgwcoky - ffvsqctwpt)
-
21 May 2025
Not Applicable
-
Ceralasertib 160mg BID 7on/7off
yfoytthbti(tpxjbwzugi) = n=1, grade 3 or higher AEs with 7on/7off dosing jmjbmliheu (bcacelhfau )
-
07 Dec 2024
Ceralasertib 160mg BID 14on/14off
Phase 2
49
(Cohort 1 (DRPro))
mydgwbnnhf = nkqfsuqqqv jjgubktapu (qlsuzmkdhv, ssesynrgxw - pzphjcviuk)
-
12 Aug 2024
(Cohort 2 (DRDef))
nnzvpurdri(ngttrxcmya) = qxrwskzqwl kosuvuqcki (cmgwimptqn, bqtrhrjoze - edmriaawvg)
Phase 2
57
(Cohort A (aST): 160 mg of Ceralasertib)
xhivcyxarn = dwgsyjxitx egeemtblfp (qtazsspyuf, vhlxojdrkp - rjqbgliujs)
-
25 Jun 2024
(Cohort B (mCRPC): 160 mg of Ceralasertib)
zmfctkouqn = bzjwhttmtz qmwqnpxpid (rhfurshdsd, weawqukrjo - axoumpeato)
Phase 2
Platinum-sensitive epithelial ovarian cancer
genomic instability | HRD positive | LOH
37
ekpvcaokvj(btppaxaryg) = ngqogvkajw gcgylwjxcq (zpalealwim )
Positive
24 May 2024
Phase 2
45
nssfwwyscq(hfdcnkxmxf) = weihoxxifv opqbgankkj (qofkshyxww, 1.9 - 17.9)
Negative
05 Apr 2024
nssfwwyscq(hfdcnkxmxf) = yyklpwqndd opqbgankkj (qofkshyxww, 0.8 - 26.8)
Phase 2
268
xhaijtetih(bpvsotikyw) = imetvdymmu ftrpmwoqks (gojpuzrtrn )
Positive
01 Mar 2024
xhaijtetih(bpvsotikyw) = axraftghds ftrpmwoqks (gojpuzrtrn )
Phase 1
67
Ceralasertib 20-240 mg BD
swojihygab(tbqzfewdhg) = xwsjwezeus ltwdybzekw (qcfkwwcdpz )
Positive
16 Jan 2024
Phase 2
31
(KRASmut patients received previous ICB)
rvpnkzlpaw(woqhmjnqpi) = gtiggdzrnl nirrphcauu (pzzihcjtiq )
Positive
10 Sep 2023
(ICB exposed KRAS wild-type patients)
rvpnkzlpaw(woqhmjnqpi) = rkcjkmyrmn nirrphcauu (pzzihcjtiq )
Phase 3
580
wcshgfbzqe(yhabzajjlh) = mvxesktxck yopminbalu (nynmcblvdu, 14.1–20.3)
-
31 May 2023
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Core Patent

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Clinical Trial

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Approval

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Regulation

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