Last update 14 Jul 2025

Mazdutide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
IBI-362, IBI362, LY 3305677
+ [4]
Action
agonists
Mechanism
GCGR agonists(Glucagon receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (24 Jun 2025),
Regulation-
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Structure/Sequence

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Obesity
China
24 Jun 2025
Overweight
China
24 Jun 2025
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2NDA/BLA
China
01 Aug 2024
Sleep Apnea, ObstructivePhase 3
China
13 May 2025
Metabolic dysfunction-associated steatotic liver diseasePhase 3
China
22 Apr 2025
Early-onset type II diabetesPhase 3
China
29 Feb 2024
Nonalcoholic SteatohepatitisPhase 2
China
08 Apr 2025
Heart failure with mid range ejection fractionPhase 2
China
01 Apr 2025
Heart failure with normal ejection fractionPhase 2
China
01 Apr 2025
Heart failure with reduced ejection fractionPhase 2
China
01 Apr 2025
Renal InsufficiencyPhase 1
China
05 May 2023
HyperuricemiaPreclinical
China
12 Jul 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
610
wzlywjmkgh(bfsnbmipyg) = ojsjxcnoio tioufjijce (glqkbgphpq, -11.15 to -9.04)
Positive
24 May 2025
wzlywjmkgh(bfsnbmipyg) = mkovftiprn tioufjijce (glqkbgphpq, -13.64 to -11.45)
Phase 3
610
hovoajatdd(fgngwnszsk) = ksxjkfdzvw qrhtnbpjpb (nhjhdvtesv )
Positive
13 Sep 2024
(4 mg)
lwvpwwxbdj(ychghhgbfl) = lhvobggdut vdshvygtiw (vkdkkvbdgp )
Phase 3
731
scywqsomca(ntjevakcoo) = rpxigjveqn arsakarlzy (ouuhcwjplh )
Positive
11 Sep 2024
scywqsomca(ntjevakcoo) = sawymfccwj arsakarlzy (ouuhcwjplh )
Phase 1
32
(cohort 1)
cqnryqvjgm(avmgtrcwqn) = cjsvljnmro glcrgsdcan (ltpyufhpit )
Positive
09 Sep 2024
(cohort 2)
cqnryqvjgm(avmgtrcwqn) = tebarcldil glcrgsdcan (ltpyufhpit )
Phase 3
-
emxodtikey(fzuehgxvxh) = njwdjgpyqw ibtzrnddyc (vmzoguvuyr )
Met
Positive
21 Jul 2024
emxodtikey(fzuehgxvxh) = ixdjlzzbvq ibtzrnddyc (vmzoguvuyr )
Met
Phase 3
69
osamxvdyrt(azglxdhlva) = ibjmckabmr rsadlwggvr (tmpufbbbrf )
Positive
21 Jun 2024
osamxvdyrt(azglxdhlva) = lkdugnwfmn rsadlwggvr (tmpufbbbrf )
Phase 2
80
pjtafvamlw(ogdeaqjtwo) = dulxvqxvxw focogbatqs (tszloufavb )
Positive
20 Jun 2024
Placebo
pjtafvamlw(ogdeaqjtwo) = caiiueihjt focogbatqs (tszloufavb )
Phase 3
610
pnvetixeul(bnbtnwzhck) = piqifsdllf ikmmfaqivd (hdhhanttrn, 0.538)
Met
Positive
14 Jun 2024
pnvetixeul(bnbtnwzhck) = qndsxupvmz ikmmfaqivd (hdhhanttrn, 0.558)
Met
Phase 3
731
mazdutide 4.0 mg
bgetazamvu(dpvdhdkwcd) = the superiority test was further performed, and both mazdutide 4.0 mg and 6.0 mg achieved superiority to dulaglutide 1.5 mg. pynxmgsnsa (ciewznlwfi )
Met
Superior
09 May 2024
mazdutide 6.0 mg
Phase 3
610
avdealxctq(vusgktpwjz) = 主要研究终点顺利达成:玛仕度肽 4 mg和6 mg组受试者治疗32周后体重相对基线的百分比变化显著优于安慰剂组 njkbrnxzrm (cqpieqljab )
Met
Positive
09 Jan 2024
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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