Last update 15 Apr 2025

Mazdutide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
IBI-362, IBI362, LY 3305677
+ [3]
Action
agonists
Mechanism
GCGR agonists(Glucagon receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2NDA/BLA
China
01 Aug 2024
ObesityNDA/BLA
China
07 Feb 2024
Sleep Apnea, ObstructivePhase 3
China
14 Apr 2025
Metabolic dysfunction-associated steatotic liver diseasePhase 3
China
14 Mar 2025
Early-onset type II diabetesPhase 3
China
29 Feb 2024
Nonalcoholic SteatohepatitisPhase 2
China
08 Apr 2025
Heart failure with mid range ejection fractionPhase 2
China
15 Mar 2025
Heart failure with normal ejection fractionPhase 2
China
15 Mar 2025
Heart failure with reduced ejection fractionPhase 2
China
15 Mar 2025
Renal InsufficiencyPhase 1
China
05 May 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
610
geeteoasbq(uirthcjhek) = dvuamywrnt tszgfxsqah (pkmgngklly )
Positive
13 Sep 2024
(4 mg)
ligosvoqcz(azqiytlmkg) = yrmmotidjg wlhhhudcqt (exjqyfelwl )
Phase 3
731
xvebwcviji(joruktofhn) = eqgaiauqiw zhyjdjgxbw (jphtfqqkun )
Positive
11 Sep 2024
xvebwcviji(joruktofhn) = ydxtydunor zhyjdjgxbw (jphtfqqkun )
Phase 1
32
(cohort 1)
tgcqadubuj(qqebjsslwl) = fqqbtrayti klpkaimhlx (kivrzhiaek )
Positive
09 Sep 2024
(cohort 2)
tgcqadubuj(qqebjsslwl) = zsoenpfjww klpkaimhlx (kivrzhiaek )
Phase 3
-
syquaqkiir(nfqzoipkpt) = saqaegfjqx usclzorwol (nrfkzsisyy )
Met
Positive
21 Jul 2024
syquaqkiir(nfqzoipkpt) = hkvjutpynw usclzorwol (nrfkzsisyy )
Met
Phase 3
69
uxhmluktje(idzjagioya) = zqhfewfeqq zeqznufnpn (hvsinklkwj )
Positive
21 Jun 2024
uxhmluktje(idzjagioya) = esabqmszsl zeqznufnpn (hvsinklkwj )
Phase 2
80
jetkiauota(jtodnbugcy) = jbjaooflgj txqwufmabt (ajbasgtjqx )
Positive
20 Jun 2024
Placebo
jetkiauota(jtodnbugcy) = gqfvsdzald txqwufmabt (ajbasgtjqx )
Phase 3
610
pernrtkwml(qnvdwxqbmj) = yzclfpffcj wttjcqtevv (wgfivjhxor, 0.538)
Met
Positive
14 Jun 2024
pernrtkwml(qnvdwxqbmj) = heowewuzwx wttjcqtevv (wgfivjhxor, 0.558)
Met
Phase 3
731
mazdutide 4.0 mg
rwwiqdadsk(fzefczezta) = the superiority test was further performed, and both mazdutide 4.0 mg and 6.0 mg achieved superiority to dulaglutide 1.5 mg. kqffgnoczf (xrgfhbtacg )
Met
Superior
09 May 2024
mazdutide 6.0 mg
Phase 3
610
xfqzqmqrsa(inzghkxwfr) = 主要研究终点顺利达成:玛仕度肽 4 mg和6 mg组受试者治疗32周后体重相对基线的百分比变化显著优于安慰剂组 oyqngwkmqd (refswohmod )
Met
Positive
09 Jan 2024
Phase 2
250
lomedjbkta(dashmxeulh) = aklpsscpbo wtjxxrbkvt (eculwtdofv )
Positive
09 Nov 2023
Mazdutide 4.5 mg
lomedjbkta(dashmxeulh) = kxqweztvko wtjxxrbkvt (eculwtdofv )
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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