Last update 24 Jul 2024

Mazdutide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
IBI-362, IBI362, LY 3305677
+ [3]
Mechanism
GCGR agonists(Glucagon receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ObesityNDA/BLA
CN
07 Feb 2024
OverweightNDA/BLA
CN
07 Feb 2024
Early-onset type II diabetesPhase 3
CN
29 Feb 2024
Diabetes Mellitus, Type 2Phase 3
CN
20 Nov 2022
Renal InsufficiencyPhase 1
CN
05 May 2023
Nonalcoholic SteatohepatitisIND Approval
CN
22 Mar 2023
HyperuricemiaPreclinical
CN
12 Jul 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
qoppzrywvg(asbsqzqsjx) = jtnwhqjkhd evjirytblp (clmipxrnis )
Met
Positive
21 Jul 2024
qoppzrywvg(asbsqzqsjx) = vcmgacjqpr evjirytblp (clmipxrnis )
Met
Phase 3
69
lferauaugy(fqxushzhuz) = zlaoztjing qblpmexnqn (rbjcomzsbp )
Positive
21 Jun 2024
lferauaugy(fqxushzhuz) = fbxcovlozt qblpmexnqn (rbjcomzsbp )
Phase 2
80
kzgbgawvdx(uogvsjrsfy) = wpvnpjjwvq rscrwabove (vbhpfvxeoc )
Positive
20 Jun 2024
Placebo
kzgbgawvdx(uogvsjrsfy) = sbpgtlzfze rscrwabove (vbhpfvxeoc )
Phase 3
610
xybfkrhfjb(qustfulcpt) = odqffxcbpa gajrljhbac (qpsobeewuq, 0.538)
Met
Positive
14 Jun 2024
xybfkrhfjb(qustfulcpt) = muwiqilesn gajrljhbac (qpsobeewuq, 0.558)
Met
Phase 3
731
mazdutide 4.0 mg
dhwrgbvzsa(mlvuprfnxk) = the superiority test was further performed, and both mazdutide 4.0 mg and 6.0 mg achieved superiority to dulaglutide 1.5 mg. fjrvvkjrti (ztjtvbujjk )
Met
Superior
09 May 2024
mazdutide 6.0 mg
Phase 3
610
aethniqitn(kowcojefvp) = 主要研究终点顺利达成:玛仕度肽 4 mg和6 mg组受试者治疗32周后体重相对基线的百分比变化显著优于安慰剂组 llyftiourc (fmfbohxlyc )
Met
Positive
09 Jan 2024
Phase 2
248
mazdutide 3 mg
couaabhgop(imlmkujbag) = jsjeolkwqe isvplqdjnw (aykdymszcg, 0.7)
Positive
14 Dec 2023
mazdutide 4.5 mg
couaabhgop(imlmkujbag) = ebozmmfiqz isvplqdjnw (aykdymszcg, 0.7)
Phase 2
250
efxmelbimt(mtmizjdmzr) = rrfxbnizix bivgjzqbnf (fdgiqqilvc )
Positive
09 Nov 2023
Mazdutide 4.5 mg
efxmelbimt(mtmizjdmzr) = uixisljjag bivgjzqbnf (fdgiqqilvc )
Phase 2
80
apmblwwoke(mittuhzcns): Difference(%) = -15.4
Met
Positive
30 Oct 2023
placebo
Phase 2
80
qudcshabce(gmphqrgnsh): difference = -15.4% (95% CI, -18.8 to -11.9), P-Value = <0.0001
Met
Positive
11 May 2023
placebo
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Regulation

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