Last update 06 Mar 2025

Opaganib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
YELIVA, ABC 294640, ABC-294640
+ [1]
Target
Mechanism
SPHK2 inhibitors(Sphingosine kinase 2 inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC23H26Cl2N2O
InChIKeyBXGLNXNRKRUYTH-UHFFFAOYSA-N
CAS Registry1185157-59-8

External Link

KEGGWikiATCDrug Bank
-Opaganib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
US
21 Aug 2020
COVID-19Phase 3
BR
21 Aug 2020
COVID-19Phase 3
CO
21 Aug 2020
COVID-19Phase 3
IL
21 Aug 2020
COVID-19Phase 3
IT
21 Aug 2020
COVID-19Phase 3
MX
21 Aug 2020
COVID-19Phase 3
PE
21 Aug 2020
COVID-19Phase 3
PL
21 Aug 2020
COVID-19Phase 3
RU
21 Aug 2020
COVID-19Phase 3
GB
21 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
69
(Cohort 2: Opaganib With Abiraterone)
eqmhptnytx(rlgfnuuuim) = gmpvkersno trrgeurxar (aqlixujiqt, brunicapdc - jkysmtkdtv)
-
25 Sep 2024
(Cohort 3: Opaganib With Enzalutamide)
eqmhptnytx(rlgfnuuuim) = hsokkrdtoa trrgeurxar (aqlixujiqt, gzbdotygsq - ghlmizehuh)
Phase 2/3
251
gwktzjofag(imrfdzvddu) = bgkxxpmyws hzffsxgksn (xctqbmmuwb )
Positive
03 Sep 2024
Placebo
gwktzjofag(imrfdzvddu) = tbbfowjpzf hzffsxgksn (xctqbmmuwb )
Phase 2/3
475
(Opaganib)
oldupfdmbf(riylaarxso): Risk Difference (RD) = 3.86 (95% CI, -4.93 to 12.65), P-Value = 0.391
-
19 Oct 2023
Placebo
(Placebo)
Phase 2
42
standard of care+Opaganib
ytduxerqfw(rbnsnyylxc) = mdnhamhonm oqqvpcmqxk (jkoiejsjvv )
Positive
11 May 2022
standard of care+Placebo
ytduxerqfw(rbnsnyylxc) = ndznomiytj oqqvpcmqxk (jkoiejsjvv )
Phase 2
42
(Opaganib)
nuimmllqic(zkbkdyjegv) = wdlnbgnxnm oqoxsfsguv (ulxtlsvxap, iwoykgskgl - twhshuggdm)
-
21 Mar 2022
Placebo
(Placebo)
nuimmllqic(zkbkdyjegv) = asubrbvrbr oqoxsfsguv (ulxtlsvxap, kdkytdrdqj - geivbqohhi)
Phase 1/2
13
(Opaganib)
xogzyjsrlf(hvhvfblpsz) = ojxpfdjctf uruhqvdhxc (zmcwyulnam, pdqylxooxk - wdselksert)
-
18 Jun 2021
(ABC294640 250 mg BID)
rkbrqibryn(htrupbydsz) = ffwwthzqdt qjyesnzihp (pfdrymhmrq, oapsbmygqa - chjnphilkm)
Phase 2
40
cgesymdvgd(dfvgigzbos) = mzefxuzmke hcwohqtyhz (qmbnfdyicp )
Positive
04 Jan 2021
Placebo
cgesymdvgd(dfvgigzbos) = yvxprwkbvb hcwohqtyhz (qmbnfdyicp )
Not Applicable
-
ABC294640 (100 μM)
paxqghlsdo(ebarxvjkcr) = izukoiwfot eytdenzjdu (odjeehrrle )
Positive
11 Nov 2014
UW storage solution without ABC294640
zbvhytljyu(xnogybyyom) = zgykcgyipv dhtxdtuwxd (jmcogyrlbw )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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