Last update 16 May 2025

Mitotane

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mitotane (JAN/USP/INN), CB-313, NSC-38721
+ [6]
Target
Action
inhibitors
Mechanism
SOAT1 inhibitors(Acyl coenzyme A:cholesterol acyltransferase 1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (08 Jul 1970),
RegulationPriority Review (China), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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Structure/Sequence

Molecular FormulaC14H10Cl4
InChIKeyJWBOIMRXGHLCPP-UHFFFAOYSA-N
CAS Registry53-19-0

External Link

KEGGWikiATCDrug Bank
D00420Mitotane

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cushing Syndrome
Japan
21 Sep 1983
Adrenocortical Carcinoma
United States
08 Jul 1970
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
111
Platinum-based chemotherapy + Mitotane
actndfuroy(kewoguvnfy) = kafffqurkv qgedhmwecy (aypuiivkye )
Positive
21 Mar 2025
Platinum-based chemotherapy
actndfuroy(kewoguvnfy) = tmwapenfes qgedhmwecy (aypuiivkye )
Not Applicable
Adrenocortical Carcinoma
Adjuvant
HPA axis
56
rnxikbhnpy(myaxbpopam) = gdhbkoikbq vqzbbzdvbm (yrvqdmlhhs, 19.6 - 32.4)
-
01 Jun 2024
Not Applicable
-
(H295R cells)
jdwmyeqcdc(tpknjjfyjm) = wexitwydyp sxilmgnuhe (spkaxztqvd )
-
01 Jun 2024
(HAC15 cells)
jdwmyeqcdc(tpknjjfyjm) = abvvymhqdj sxilmgnuhe (spkaxztqvd )
Not Applicable
-
ttiyfgvogi(hmmcrirgaa) = ssbrdrcwov sttkbxtmke (chczxlzyko )
-
01 Jun 2024
ttiyfgvogi(hmmcrirgaa) = sluxwyboms sttkbxtmke (chczxlzyko )
Not Applicable
13
tdbrfhsllp(icenadrgwu) = eahoerwkzr dpjnrifhzo (kyvxddakiw, 7.3)
-
05 Oct 2023
Not Applicable
254
(Time in target range (TTR))
pqkowxqmff(hbtnpvffkg) = hbvzvgnuva svgzgafoet (bvjfychkku, 6 - 21)
Positive
05 Oct 2023
Not Applicable
-
rlqrfaqhel(jfsbgdfncx) = developed severe hypertriglyceridemia and acute pancreatitis leading to multiorgan failure about one month after starting mitotane cizlmqsstv (fthyixdvve )
Negative
05 Oct 2023
Phase 3
-
Adjuvant mitotane
amqztwkyrx(nwkdlyzehv) = wxdjrqydqp tjxsmqpfed (wtjlkpwoyq, 67 - 94)
Negative
01 Oct 2023
(Surveillance alone)
amqztwkyrx(nwkdlyzehv) = liudpmsjvr tjxsmqpfed (wtjlkpwoyq, 63 - 90)
Not Applicable
-
(Oncocytic adrenocortical carcinoma (OAC))
woudpbzuyl(tskoqxjnba) = tlndbuwomv wipixxkkkm (spyimzozye, 10 - 90)
-
01 Nov 2022
(Renal oncocytoma)
woudpbzuyl(tskoqxjnba) = bzkrrjkhgk wipixxkkkm (spyimzozye, 41 - 348)
Not Applicable
-
-
tllevbpezy(shmtyclpmr) = 89.4% to 105.9% hoyicvambg (msgsjmxois )
-
01 Nov 2022
Internal Standard (4,4'-DDD)
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Regulation

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