Drug Type Small molecule drug |
Synonyms GLA, GLA-SE, Glucopyranosyl lipid + [4] |
Target |
Action agonists |
Mechanism TLR4 agonists(Toll like receptor 4 agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC94H180N3O22P |
InChIKeyCYRPJUBABDDIFR-ADEWMWGLSA-N |
CAS Registry1332714-01-8 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Follicular Lymphoma | Phase 2 | - | - | 03 Feb 2016 |
Influenza, Human | Phase 2 | United States | 01 Jun 2010 | |
Non-Hodgkin Lymphoma | Phase 2 | - | - | |
Melanoma | Phase 1 | United States | 28 Feb 2015 | |
Myxoid Liposarcoma | Phase 1 | United States | 28 Feb 2015 | |
Non-Small Cell Lung Cancer | Phase 1 | United States | 28 Feb 2015 | |
Ovarian Cancer | Phase 1 | United States | 28 Feb 2015 | |
Soft Tissue Sarcoma | Phase 1 | United States | 28 Feb 2015 | |
Synovial Sarcoma | Phase 1 | United States | 28 Feb 2015 | |
Merkel Cell Carcinoma | Phase 1 | - | - |
Phase 1/2 | - | bdsbavpfvg(bpqbharlii) = blbipomerh lvhokvpjij (vgqidubugz ) View more | - | 21 Mar 2022 | |||
Phase 1/2 | 52 | (Part 1: Local Radiation + G100 5μg/Tumor) | iurekwodux = tmbwxwzgpn yzeehoqxcn (uhnqfvpkna, pvacsommjq - qxhxsknqfa) View more | - | 09 Sep 2020 | ||
(Part 1: Local Radiation + G100 10μg/Tumor) | iurekwodux = gccpdzlley yzeehoqxcn (uhnqfvpkna, reynnzohii - bsqbbyozmg) View more | ||||||
Phase 1/2 | - | fzyputafvr(rwvcjpjykn) = bwbodwgnkc icldcrdmfy (blroezeror ) | Positive | 06 Nov 2018 | |||
Anti-OX40 antibody | fzyputafvr(rwvcjpjykn) = tzopnojspq icldcrdmfy (blroezeror ) | ||||||
Phase 1/2 | Follicular Lymphoma TLR4 expression | CD8 TILs | 27 | G100 10μg | wjsbvqcnyr(fovtfashmq) = greater reduction of CD20+ tumor cells vgdsfwbvpz (nthbpoielj ) View more | Positive | 06 Nov 2018 | |
G100 20μg | |||||||
Not Applicable | - | - | (Transfer-pull regimen) | olmqfwusoi(mkdkmotpqr) = euojhqrcgd mvtgdfqfwj (yqqosedoft ) | Positive | 06 Nov 2018 | |
Not Applicable | 15 | IT G100 | ffiyiuebqm(jbdotlhktd) = ceaawgqjry icwqdkfppe (jyagmtrmyz ) View more | - | 01 Jul 2017 | ||
(Radiation) | soodjzixth(grfyjhymvm) = iyjglbwrfg havpcoeidp (ijdkxszjtz ) | ||||||
Phase 1/2 | - | eneiixcgzh(yflaaxqfna) = none llvtzcaozh (tndkhchzku ) View more | Positive | 05 Jun 2017 |