Last update 21 Nov 2024

sEphB4-HSA

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
EphB4-Human Serum Albumin, Human Serum Albumin-EphB4 conjugate, RECOMBINANT EPHB4-HSA FUSION PROTEIN
+ [3]
Target
Mechanism
EphB4 antagonists(Ephrin type-B receptor 4 antagonists)
Originator Organization
Active Organization
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic urothelial carcinomaPhase 3-01 Nov 2024
Muscle Invasive Bladder CarcinomaPhase 3-01 Nov 2024
Metastatic castration-resistant prostate cancerPhase 2
US
20 Sep 2019
Metastatic Prostate CarcinomaPhase 2
US
20 Sep 2019
Kaposi SarcomaPhase 2
US
13 Feb 2018
Metastatic Solid TumorPhase 2
US
03 Sep 2015
Advanced Malignant Solid NeoplasmPhase 2
US
06 Sep 2012
Advanced Malignant Solid NeoplasmPhase 2
US
06 Sep 2012
Relapsed Solid NeoplasmPhase 2
US
06 Sep 2012
Relapsed Solid NeoplasmPhase 2
US
06 Sep 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
(lejcnymszj) = Three patients experienced a serious adverse event potentially related to therapy, including 1 patient with a grade 5 event (cerebral vascular accident) possibly related to the study drug qfbimnbafb (kmcgbldeyo )
Negative
07 Sep 2022
Phase 2
14
moxoqejifv(jjnawpteze) = dacogczlui xlcrcoijxd (ezeyvayfsb, sxhzhezsnl - mmpniylxlk)
-
27 Apr 2022
Phase 2
14
hupedazfqo(mtzyjposoi) = xndktepqwr kiyzecdkyk (peylrxuyyt )
Negative
16 Feb 2022
Phase 2
62
techermhsn(cctmpnxuxq) = Median cycles of treatment 5 (range 1-36). 6 pts still on treatment , 5 pts off treatment without PD. 36 (52%) off treatment due to PD, 4 toxicities 1 grade (G) 3 arthralgia, 1 G3 edema, 1 G3 abdominal pain and 1 G3 supraventricular tachycardia, 4 died on treatment (1 organ failure attributed to P, 1 aspiration pneumonia, 2 decline in health status) kpbegtbsgv (yfhgsiuydl )
Positive
17 Sep 2021
Phase 1
44
(pancreatic cancers)
(shvqrsvtwd) = hypertension (n = 16; 36%), neutropenia (n = 15; 34%), anemia (n = 14; 32%), thrombocytopenia (n = 7, 16%), fatigue (n = 7, 16%). xqnnreaxeg (mqxyiodetj )
Positive
25 May 2020
gemcitabine+cisplatin+sEphB4-HSA
(biliary cancers)
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Regulation

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