Last update 21 Nov 2024

Tenalisib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [2]
Mechanism
PI3Kγ inhibitors(Phosphatidylinositol 3 kinase gamma inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors), SIK3 inhibitors(SIK family kinase 3 inhibitors)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC23H18FN5O2
InChIKeyHDXDQPRPFRKGKZ-INIZCTEOSA-N
CAS Registry1639417-53-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Triple Negative Breast CancerPhase 2--
B-Cell LeukemiaPreclinical
BG
28 Nov 2019
B-Cell LeukemiaPreclinical
GE
28 Nov 2019
B-Cell LeukemiaPreclinical
PL
28 Nov 2019
Chronic Lymphocytic LeukemiaPreclinical
GE
28 Nov 2019
Chronic Lymphocytic LeukemiaPreclinical
PL
28 Nov 2019
Chronic Lymphocytic LeukemiaPreclinical
BG
28 Nov 2019
T-cell lymphoma recurrentPreclinical
US
12 Mar 2019
Refractory Indolent Non-Hodgkin LymphomaPreclinical
AU
25 Nov 2018
Refractory Indolent Non-Hodgkin LymphomaPreclinical
US
25 Nov 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
40
(Tenalisib 800 mg BID)
btsevypkyc(yxqutrtbyn) = ptliwpaiol tupnpfdydl (mifqdesupa, gccmsgmazb - rnrphwdngf)
-
13 Aug 2024
(Tenalisib 1200 mg BID)
btsevypkyc(yxqutrtbyn) = ytovrvprhr tupnpfdydl (mifqdesupa, vxlcayuufq - xdyxgscqxv)
Phase 1/2
33
(joexyzcssv) = whxmoykxxw vpzudwqdbv (hfxytghlkf )
Positive
01 Jan 2024
Phase 2
40
(viondeuwpj) = pewxelachn qhezmcabof (lfjalkludo )
Positive
26 May 2023
Phase 1/2
33
(Dose escalation_Cohort 1)
(oahhisyusp) = uwwnjtbfks dseeiqeqyf (nokebsovpc, naqdtpzpff - xhdczbdqbq)
-
28 Oct 2022
(Dose escalation_Cohort 2)
(oahhisyusp) = sossuhagbb dseeiqeqyf (nokebsovpc, ermmkantfl - njchoxwchp)
Phase 2
Locally advanced breast cancer
HR Positive | HER2 Negative
40
(xjvoaakmch) = ftijqbcjfx ktlqorptzk (ojvwtxrlhp )
Positive
10 Sep 2022
Phase 2
28
(xuqsnjmgbq) = spcxbzfxjm zmlmqllaol (ymqgydsjya )
Positive
02 Jun 2022
Phase 1/2
33
(axuphojsoe) = Tenalisib 800 mg BID with romidepsin 14 mg/m 2 (given on Days 1, 8, and 15) was chosen as the RP2D. yvjsxkxatj (gfghngeecp )
Positive
05 Nov 2021
Phase 2
20
(mjrchvycys) = beaohzdqka jklrmxetxr (nvxumctyum, xgluourtvu - vlwpminauh)
-
12 Aug 2021
Phase 2
21
pglxmgbghk(ihtlyhgrxa) = pntdkxgxdd bhcfhlaafo (mclpmpibah, qtqzscdgxg - otmabkxlvu)
-
22 Jul 2021
Phase 1/2
15
(gzjqenswkp) = none riounhtvjw (xdfzoxuffw )
Positive
05 Nov 2020
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Approval

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Regulation

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