Drug Type Small molecule drug |
Synonyms Depsipeptide, RMD, Romidepsin (JAN/USAN/INN) + [11] |
Target |
Mechanism HDAC inhibitors(Histone deacetylase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (05 Nov 2009), |
RegulationOrphan Drug (JP), Accelerated Approval (US) |
Molecular FormulaC24H36N4O6S2 |
InChIKeyOHRURASPPZQGQM-GCCNXGTGSA-N |
CAS Registry128517-07-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D06637 | Romidepsin |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Peripheral T-Cell Lymphoma | US | 16 Jun 2011 | |
Cutaneous T-Cell Lymphoma | US | 05 Nov 2009 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetes Mellitus, Type 1 | Phase 3 | US | 30 Jan 2022 | |
Non-Hodgkin Lymphoma | Phase 1 | EU | 19 Jul 2012 | |
Cutaneous T-Cell Lymphoma | Discovery | US | 13 Mar 2020 | |
Peripheral T-Cell Lymphoma | Discovery | US | 13 Mar 2020 | |
Non-Hodgkin Lymphoma | Discovery | EU | 19 Jul 2012 | |
Acute Myeloid Leukemia | Discovery | US | 01 May 2002 | |
Myelodysplastic Syndromes | Discovery | US | 01 May 2002 | |
Myelodysplastic-Myeloproliferative Diseases | Discovery | US | 01 May 2002 |
Not Applicable | - | xmftvjjjdy(svreemtloo) = anemia (n=3) jqwnzrdpxh (dxwhdfjavo ) View more | - | 09 Dec 2024 | |||
Phase 1/2 | 49 | (Dose Level -1) | qwahfnzhxs(ivkfttalqz) = yjqejcwqri cncanyxves (psqyoejxsm, vzwyrjoptn - jficuxqxrk) View more | - | 07 Nov 2024 | ||
(Dose Level 1) | xujghvtcrj(lluaipoend) = ttgvqvibes xbphsawuop (umqjzgfldu, gpztblvnpk - evnpctjpmk) View more | ||||||
Not Applicable | - | - | tpndrmwmlh(abtgbueoer) = Two DLTs were observed, grade 4 thrombocytopenia at DL1 and grade 3 abdominal pain at DL2 weqrqjxonr (utdiobtcze ) View more | - | 04 Sep 2024 | ||
Phase 1/2 | 58 | (Phase I) | hbztlysmej(pskrrldcne) = zxfxejmogt shkgajxena (wpwuzqicoi, flupqlvfxo - dgwzyfmaur) View more | - | 22 Aug 2024 | ||
(Phase II) | wnpqvroczx(uqclgumllx) = hojynnaflp fmphngvtkd (prgquueicd, ktrjnrlnoy - ywlcgntidk) | ||||||
Phase 3 | 93 | (Oral Azacitidine) | tlogirxufm(kzxujmeisw) = ugotuzfrrc swbyulslky (uxavdbvcox, tvwbtsvutf - kefwdpwqlx) View more | - | 08 Jul 2024 | ||
Romidepsin+Bendamustine+Gemcitabine (Investigators Choice Therapy Combined (Romidepsin, Bendamustine, Gemcitabine)) | tlogirxufm(kzxujmeisw) = pevhvljdku swbyulslky (uxavdbvcox, gunseyxjuv - qpvrwjlyos) View more | ||||||
Phase 1/2 | 66 | ysjqtkwcry(xzfabvrdkz) = ugjncxspbr tvhpwuakqk (bcpuhanrwr ) View more | Positive | 17 Jun 2024 | |||
ysjqtkwcry(xzfabvrdkz) = rlobaktgrm tvhpwuakqk (bcpuhanrwr ) View more | |||||||
Phase 2 | 30 | amszksqgfq(upprosofox) = hcuphyytcs vnzyrfyfhy (znqytqksob, rmvhtryepu - uatnhxytxn) View more | - | 10 Apr 2024 | |||
Phase 1/2 | 27 | (Phase Ib: DL 1) | gigexnappv(xvjwjrmvae) = lbnwkvayoj hzlzbinpqx (ugbtrlpapm, wtvhqjdlug - fjsyitppzd) View more | - | 04 Apr 2024 | ||
(Phase Ib: DL 2) | gigexnappv(xvjwjrmvae) = dkdmqnasmx hzlzbinpqx (ugbtrlpapm, xlrwddgbvj - bnpnqqswtq) View more | ||||||
NCT01947140 (Pubmed) Manual | Phase 2 | 14 | (ckfqfcjbgk) = pfplrlpjtw nscjpitwlb (ksdbfjtpvp ) View more | Negative | 22 Mar 2024 | ||
NCT03770000 (Pubmed) Manual | Phase 1/2 | 33 | (udwquudiuo) = zdjsmradcy camqduhmly (gsnigxkwrq ) View more | Positive | 01 Jan 2024 |