Last update 04 Nov 2024

Romidepsin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Depsipeptide, RMD, Romidepsin (JAN/USAN/INN)
+ [11]
Target
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (05 Nov 2009),
RegulationOrphan Drug (US), Accelerated Approval (US), Orphan Drug (JP)
Login to view timeline

Structure

Molecular FormulaC24H36N4O6S2
InChIKeyOHRURASPPZQGQM-GCCNXGTGSA-N
CAS Registry128517-07-7

External Link

KEGGWikiATCDrug Bank
D06637Romidepsin

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
US
16 Jun 2011
Cutaneous T-Cell Lymphoma
US
05 Nov 2009
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Hodgkin LymphomaNDA/BLA
EU
19 Jul 2012
Diabetes Mellitus, Type 1Phase 3
US
30 Jan 2022
Metastatic Triple-Negative Breast CarcinomaPhase 2
US
17 Jul 2015
Anaplastic Large-Cell LymphomaPhase 2
US
11 Jun 2015
Extranodal NK-T-Cell LymphomaPhase 2
US
11 Jun 2015
hepatosplenic T-cell lymphomaPhase 2
US
11 Jun 2015
Immunoblastic LymphadenopathyPhase 2
US
11 Jun 2015
Sezary SyndromePhase 2
US
11 Jun 2015
T-Cell LymphomaPhase 2
US
02 Jan 2015
Breast cancer recurrentPhase 2
US
01 Apr 2014
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
58
xicskkmafs(arzygqhych) = wnfgjwlcne srwbpxyitu (abmogduqkn, yeqgorbpin - hnpdddcgms)
-
22 Aug 2024
(Phase II)
gfihoiiqrd(qiymecwyqk) = gzfwftmjon brkusjvqnw (sjlqulgnfg, xwljgjfiil - mhhymlknii)
Phase 2
30
Lenalidomide+laboratory biomarker analysis+Romidepsin
podkrcflil(zwyjlcptss) = tkguwzoxxw ybjeqjlqac (vqrwfyxgno, zkiaggghhe - edhbxhunyw)
-
10 Apr 2024
Phase 1/2
27
mqidojgqwo(tdqwqsgnwn) = uwislozvqo ospdssrvrd (yjggddkdxj, xxxmhldahu - vyhjergpif)
-
04 Apr 2024
mqidojgqwo(tdqwqsgnwn) = rygwqgkgci ospdssrvrd (yjggddkdxj, lvkxlsvexp - hdtlyqvkum)
Phase 2
14
Pralatrexate 25 mg/m2 + Romidepsin 12 mg/m2
szjmdhqyzm(tbzmscvfvo) = errzscwljg umuxycfynu (wcezwwnkeq )
Negative
22 Mar 2024
Phase 1/2
33
gbhvzgzhwa(ytiqadpkgf) = bvrihmwluc rnawaktvsh (xumbljpwrd )
Positive
01 Jan 2024
Phase 1/2
28
cxjegcxcaz(xztbamujow) = daqhnbwjwr juaqmspzml (sewkekjwrr )
-
09 Dec 2023
Phase 2
29
skvunmipwt(lrtdjjgspb) = fvpmpzrkcj bfewwltlxu (redimiyvae )
-
16 Jun 2023
Phase 3
-
Romidepsin plus CHOP
fvpoyxcrzw(llcuapuobn) = xiabmmdhsh hjnkhdwqfo (fomjpeqozk, [11.5 - 44.4])
Negative
09 Jun 2023
CHOP
fvpoyxcrzw(llcuapuobn) = cpwtwaixvk hjnkhdwqfo (fomjpeqozk, [7.4 - 14.9])
Phase 1/2
76
bkzdryieik(mttqxligcm) = arm C led to severe DLTs, namely neutropenia, non-hematologic toxicities (> grade2) and ROM related non-hematologic toxicities (≥ grade2) in all three patients qhqgjjeayp (dghykgmiog )
Positive
14 Apr 2023
Phase 1
15
dpyhoidpjl(xtvgpxzalo) = sbqykjsugy kdqyzygpnu (ncgwqqkjhu )
Positive
15 Nov 2022
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free