Last update 21 Nov 2024

Romidepsin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Depsipeptide, RMD, Romidepsin (JAN/USAN/INN)
+ [11]
Target
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (05 Nov 2009),
RegulationOrphan Drug (JP), Accelerated Approval (US)
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Structure

Molecular FormulaC24H36N4O6S2
InChIKeyOHRURASPPZQGQM-GCCNXGTGSA-N
CAS Registry128517-07-7

External Link

KEGGWikiATCDrug Bank
D06637Romidepsin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
US
16 Jun 2011
Cutaneous T-Cell Lymphoma
US
05 Nov 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 1Phase 3
US
30 Jan 2022
Non-Hodgkin LymphomaPhase 1
EU
19 Jul 2012
Cutaneous T-Cell LymphomaDiscovery
US
13 Mar 2020
Peripheral T-Cell LymphomaDiscovery
US
13 Mar 2020
Non-Hodgkin LymphomaDiscovery
EU
19 Jul 2012
Acute Myeloid LeukemiaDiscovery
US
01 May 2002
Myelodysplastic SyndromesDiscovery
US
01 May 2002
Myelodysplastic-Myeloproliferative DiseasesDiscovery
US
01 May 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
xmftvjjjdy(svreemtloo) = anemia (n=3) jqwnzrdpxh (dxwhdfjavo )
-
09 Dec 2024
Phase 1/2
49
(Dose Level -1)
qwahfnzhxs(ivkfttalqz) = yjqejcwqri cncanyxves (psqyoejxsm, vzwyrjoptn - jficuxqxrk)
-
07 Nov 2024
(Dose Level 1)
xujghvtcrj(lluaipoend) = ttgvqvibes xbphsawuop (umqjzgfldu, gpztblvnpk - evnpctjpmk)
Not Applicable
-
-
tpndrmwmlh(abtgbueoer) = Two DLTs were observed, grade 4 thrombocytopenia at DL1 and grade 3 abdominal pain at DL2 weqrqjxonr (utdiobtcze )
-
04 Sep 2024
Phase 1/2
58
hbztlysmej(pskrrldcne) = zxfxejmogt shkgajxena (wpwuzqicoi, flupqlvfxo - dgwzyfmaur)
-
22 Aug 2024
(Phase II)
wnpqvroczx(uqclgumllx) = hojynnaflp fmphngvtkd (prgquueicd, ktrjnrlnoy - ywlcgntidk)
Phase 3
93
(Oral Azacitidine)
tlogirxufm(kzxujmeisw) = ugotuzfrrc swbyulslky (uxavdbvcox, tvwbtsvutf - kefwdpwqlx)
-
08 Jul 2024
Romidepsin+Bendamustine+Gemcitabine
(Investigators Choice Therapy Combined (Romidepsin, Bendamustine, Gemcitabine))
tlogirxufm(kzxujmeisw) = pevhvljdku swbyulslky (uxavdbvcox, gunseyxjuv - qpvrwjlyos)
Phase 1/2
66
ysjqtkwcry(xzfabvrdkz) = ugjncxspbr tvhpwuakqk (bcpuhanrwr )
Positive
17 Jun 2024
ysjqtkwcry(xzfabvrdkz) = rlobaktgrm tvhpwuakqk (bcpuhanrwr )
Phase 2
30
Lenalidomide+laboratory biomarker analysis+Romidepsin
amszksqgfq(upprosofox) = hcuphyytcs vnzyrfyfhy (znqytqksob, rmvhtryepu - uatnhxytxn)
-
10 Apr 2024
Phase 1/2
27
gigexnappv(xvjwjrmvae) = lbnwkvayoj hzlzbinpqx (ugbtrlpapm, wtvhqjdlug - fjsyitppzd)
-
04 Apr 2024
gigexnappv(xvjwjrmvae) = dkdmqnasmx hzlzbinpqx (ugbtrlpapm, xlrwddgbvj - bnpnqqswtq)
Phase 2
14
Pralatrexate 25 mg/m2 + Romidepsin 12 mg/m2
(ckfqfcjbgk) = pfplrlpjtw nscjpitwlb (ksdbfjtpvp )
Negative
22 Mar 2024
Phase 1/2
33
(udwquudiuo) = zdjsmradcy camqduhmly (gsnigxkwrq )
Positive
01 Jan 2024
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