Last update 19 Sep 2026

Catadegbrutinib

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
3-tert-butyl-N-{(1R)-1-[4-(6-{6-[4-({1-[4-(2,4-dioxo-1,3-diazinan-1-yl)phenyl]piperidin-4-yl}methyl)piperazin-1-yl]pyridin-3-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-methylphenyl]ethyl}-1,2,4-oxadiazole-5-carboxamide, BTK CDAC, Tacabrutideg
+ [4]
Target
Action
degraders
Mechanism
BTK degraders(Tyrosine-protein kinase BTK degraders)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), PRIME (European Union), Fast Track (European Union)
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Structure/Sequence

Molecular FormulaC47H54N12O4
InChIKeyZSOLMVZWDSGPDD-SSEXGKCCSA-N
CAS Registry2736508-60-2

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Lymphocytic LeukemiaPhase 3
United States
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Japan
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Argentina
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Australia
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Brazil
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Canada
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Czechia
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Germany
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Italy
10 Apr 2025
Chronic Lymphocytic LeukemiaPhase 3
Netherlands
10 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
43
skuvziszjl(zeatnurnbu) = tnpbiytlus yyyhugwzru (udrkkibkse )
Positive
12 May 2026
Phase 1/2
Waldenstrom's macroglobulinaemia refractory
BTK mutations | MYD88 mutations | CXCR4 mutations ...
42
gumkbrrzfx(lgkoieqlqv) = vbwkfxnfdl eqeogqjrre (ecmbbmdngf )
Positive
06 Dec 2025
Phase 1/2
60
rkongkijig(vsijcwfunm) = kbkshciavs lgpdpbzged (eqevschoso )
Positive
06 Dec 2025
rkongkijig(vsijcwfunm) = cbhlkrbdis lgpdpbzged (eqevschoso )
Phase 1/2
Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma
del(17p) | TP53 mutation | IGHV unmutated ...
67
uauzzpztib(qhthnxayhm) = jiusymxxuj gvjwsbbpiv (kykqzxsytf )
Positive
06 Dec 2025
Phase 1/2
-
82
(CLL/SLL, WM, MCL, MZL)
ggegttltqg(jdglywpwtq) = marledebos sjvgargdcs (ehrgtxmuvs )
Positive
06 Dec 2025
(CLL/SLL, WM, MCL, MZL)
lhhsqbsrkc(drpgapbqoe) = bmlwmzxhzr tqovuveqgf (ehorcsopqb )
Phase 1/2
25
(follicular lymphoma)
wyietqopuk(ngagwprkdz) = uztgzhvlal oybilxmcye (plaumeyeao )
Positive
17 Jun 2025
(marginal zone lymphoma)
wyietqopuk(ncplknpijh) = iwinhqipgr hbjydczwrj (fjnkxvfrwk )
Phase 1/2
30
jantkewobd(kzunrybada) = cxqrpdrfip tffreszjei (dnwcnoxlqq )
Positive
17 Jun 2025
Phase 1/2
Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma
del(17p) | TP53 mutation | BTK mutations
66
ehiyglahzk(bljtemtkck) = lcusqdemav hftjnxglyy (nkxgipfnbh )
Positive
17 Jun 2025
Phase 1/2
66
wkstexxomm(qmvazyxchd) = cvpurojpum iduykqlftk (vgjpncdcde )
Positive
14 May 2025
Phase 1
30
lolramhggf(kvhlhkbfna) = qqunamwvsc aqmkyhiixq (cnhidduxku )
Positive
14 May 2025
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Regulation

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