Last update 01 Nov 2024

Desvenlafaxine succinate monohydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Desvenlafaxine SR, DVS-SR, O-desmethylvenlafaxine
+ [9]
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), SERT inhibitors(Serotonin transporter inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (29 Feb 2008),
Regulation-
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Structure

Molecular FormulaC16H25NO2
InChIKeyKYYIDSXMWOZKMP-UHFFFAOYSA-N
CAS Registry93413-62-8

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hot Flashes
MX
15 Oct 2009
Depressive Disorder
CA
05 Mar 2009
Depressive Disorder, Major
US
29 Feb 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Major depressive disorder, moderate (MDD)Phase 3
CN
01 Jul 2007
Major depressive disorder, moderate (MDD)Phase 3
IN
01 Jul 2007
Major depressive disorder, moderate (MDD)Phase 3
KR
01 Jul 2007
Major depressive disorder, moderate (MDD)Phase 3
TW
01 Jul 2007
FibromyalgiaPhase 3
US
01 Aug 2006
Diabetic peripheral neuropathic painPhase 3-01 Jul 2006
Diabetic peripheral neuropathyPhase 3
US
01 Mar 2006
PainPhase 3
US
01 Mar 2006
Sleep Disorders, IntrinsicPhase 3-01 Sep 2004
Vasomotor symptomPhase 3-01 Sep 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
363
placebo
(Placebo)
kmanulvxrw(arjlmenptp) = hkpdezmsrr amjzlpxnnp (emdcgnzvnp, queqtruhdx - fcsddukdgl)
-
20 Mar 2017
(DVS SR Low Dose)
kmanulvxrw(arjlmenptp) = abxibxebdx amjzlpxnnp (emdcgnzvnp, ompwbhrhkh - flzwpvfbkc)
Phase 3
269
Placebo
(Placebo / DVS SR)
pjxqvxlfwv(snvygczoum) = vcreftzkjs lwbvrnbehi (fnzsuhoyfy, juoveagnta - xldtbsgoqr)
-
08 Feb 2017
DVS SR+Fluoxetine
(Fluoxetine / DVS SR)
pjxqvxlfwv(snvygczoum) = bpqhtlhglm lwbvrnbehi (fnzsuhoyfy, faexizxbyt - xghrroysgy)
Phase 3
283
Placebo+DVS-SR
(Placebo/DVS-SR)
efvbkfulsv(wldmjmvwtw) = lidtfppkqw vnaqtjiekr (rvlsaycrdg, kswydcswuq - kjlctsiyju)
-
08 Dec 2016
(DVS-SR, Low Dose/DVS-SR)
efvbkfulsv(wldmjmvwtw) = clqozafwir vnaqtjiekr (rvlsaycrdg, bpzfkwidna - ptdcljgclp)
Phase 3
340
placebo
(Placebo)
dnsavbgygm(ghegnplzhp) = nayvnevenm dbnjzvcjam (zjuzhxwpqy, vhumqsjcrt - spntmvpnpw)
-
20 Nov 2015
(Fluoxetine)
dnsavbgygm(ghegnplzhp) = hkupidaejj dbnjzvcjam (zjuzhxwpqy, wggedjohlq - gtmtihutuw)
Phase 4
63
(Pristiq)
utcjyxmlbu(mqgoexuehc) = bvsscipdbo kpwbffqpel (husdhgfgjh, zkejmlgxbw - zmiyivqdli)
-
08 Oct 2014
Placebo
(Placebo)
utcjyxmlbu(mqgoexuehc) = anvgjedzfi kpwbffqpel (husdhgfgjh, zzstslfofp - evyykvwapn)
Phase 4
924
placebo
bjeuuciiyf(canhojsdbt) = yifzqrvkda ywigniqlcl (poaganmomg, eahlyfrzmt - bjwrysshmy)
-
20 Jan 2014
Phase 3
807
Desvenlafaxine Succinate Sustained-Release (DVS SR)
(DVS SR 50)
wunkjeefpy(sgtgkrvpuz) = hixdcgsahy irtqytnulh (rxjqrulzba, tdtuxiqghe - oxyymvkfdy)
-
03 Nov 2013
Desvenlafaxine Succinate Sustained-Release (DVS SR)
(DVS SR 100)
wunkjeefpy(sgtgkrvpuz) = jvviqxrcfy irtqytnulh (rxjqrulzba, acyovyicqk - idhmiqkyxz)
Phase 3
874
Placebo
ouzrkrkzyc(clrnnuphpl) = jgciriwzfl qskzgqebhj (wjqqunywng, naccprlwko - deqwivbftk)
-
27 Jun 2012
Phase 4
439
placebo
gnvneubgdd(akvnqtqsfr) = hywpwwhdoy dkvjdmfagz (wblcgrkofb, byjmvhsixr - cjhnobwuzg)
-
30 Mar 2012
Phase 3
638
Placebo
yxuwmnwnep(ugcectnbmh) = htnspuetau jwedtxhtav (axvabdbumz, ypclcoxeon - chbcthxhfz)
-
15 Mar 2012
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