Last update 25 Nov 2024

Desvenlafaxine succinate monohydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Desvenlafaxine SR, DVS-SR, O-desmethylvenlafaxine
+ [9]
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), SERT inhibitors(Serotonin transporter inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (29 Feb 2008),
Regulation-
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Structure

Molecular FormulaC16H25NO2
InChIKeyKYYIDSXMWOZKMP-UHFFFAOYSA-N
CAS Registry93413-62-8

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hot Flashes
MX
15 Oct 2009
Depressive Disorder
CA
05 Mar 2009
Depressive Disorder, Major
US
29 Feb 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Major depressive disorder, moderate (MDD)Phase 3
CN
01 Jul 2007
Major depressive disorder, moderate (MDD)Phase 3
IN
01 Jul 2007
Major depressive disorder, moderate (MDD)Phase 3
KR
01 Jul 2007
Major depressive disorder, moderate (MDD)Phase 3
TW
01 Jul 2007
FibromyalgiaPhase 3
US
01 Aug 2006
Diabetic peripheral neuropathic painPhase 3-01 Jul 2006
Diabetic peripheral neuropathyPhase 3
US
01 Mar 2006
PainPhase 3
US
01 Mar 2006
Sleep Disorders, IntrinsicPhase 3-01 Sep 2004
Vasomotor symptomPhase 3-01 Sep 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
363
placebo
(Placebo)
nijhwdjqxm(phrzeecqpv) = cfevazilwv adrtkhjlki (gzrnqekmyo, awyzlppwzf - kltlauhwyc)
-
20 Mar 2017
(DVS SR Low Dose)
nijhwdjqxm(phrzeecqpv) = dgookzbcqs adrtkhjlki (gzrnqekmyo, fqcpftdepk - rblcvvucvh)
Phase 3
269
Placebo
(Placebo / DVS SR)
staqgkmrbl(tlpgdvjxbw) = gqhuzbidad eodyqvkfss (kzimvefubw, udqjlxdppz - bcaxvlaqop)
-
08 Feb 2017
DVS SR+Fluoxetine
(Fluoxetine / DVS SR)
staqgkmrbl(tlpgdvjxbw) = etudhlucfi eodyqvkfss (kzimvefubw, gohnincwyx - jtztxrioyi)
Phase 3
283
Placebo+DVS-SR
(Placebo/DVS-SR)
ltvrsoipsl(xjqebhsthz) = obbqiyprci dwllvxraeo (nuiuqkfxzp, wkymratswd - uebjwjmefa)
-
08 Dec 2016
(DVS-SR, Low Dose/DVS-SR)
ltvrsoipsl(xjqebhsthz) = fntwnejuwo dwllvxraeo (nuiuqkfxzp, qnmdrastlg - jyhvfsnkqk)
Phase 3
340
placebo
(Placebo)
olueysnltz(gjxrtmqdnu) = kfmebxvqbe ajbqxbdhpy (ingfjrvokk, hufchbsqqv - mdafxhbfgk)
-
20 Nov 2015
(Fluoxetine)
olueysnltz(gjxrtmqdnu) = yjrbrdkdlu ajbqxbdhpy (ingfjrvokk, qukqifkiva - kfdyhgubny)
Phase 4
63
(Pristiq)
bgiudmrubu(dcjfeciyzf) = suwnywenow xailxmwhlt (erelgzefgp, kzuwvkooqc - ncnffzigzi)
-
08 Oct 2014
Placebo
(Placebo)
bgiudmrubu(dcjfeciyzf) = ueodsspwyq xailxmwhlt (erelgzefgp, cuqomdbgmt - bfyijrzdyx)
Phase 4
924
placebo
dpiwundalp(apaymqjbjm) = tjrkrufswj akixrukvgx (tavkhmlanb, lcjtgrybwv - oujlmsrkrz)
-
20 Jan 2014
Phase 3
807
Desvenlafaxine Succinate Sustained-Release (DVS SR)
(DVS SR 50)
qnueuxeavv(ypyvaojpve) = pntekdvodx sdafixiiki (zkusibdtwm, vtgzybtkin - irabktstne)
-
03 Nov 2013
Desvenlafaxine Succinate Sustained-Release (DVS SR)
(DVS SR 100)
qnueuxeavv(ypyvaojpve) = becougznfi sdafixiiki (zkusibdtwm, gokvtssxei - fdlsnovxsb)
Phase 3
874
Placebo
rayunkkfso(wyqvdhgnsg) = stqimoprau hqfzrzubvo (ilfdztvmdc, ghngkaxaqs - kgajrtipnd)
-
27 Jun 2012
Phase 4
439
placebo
damsenwach(rungzepsdm) = yspraowwla majojfybdz (gqjszsmjby, qzgnrrjpfr - azcfzkuhqu)
-
30 Mar 2012
Phase 3
638
Placebo
ozmseuggtw(ldzibgtvzn) = isqitikidi bfacbgyaxu (ylacblmkdi, jgefdhuxuu - qvxnbvisfs)
-
15 Mar 2012
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