Last update 01 Nov 2024

Sitravatinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sitravatinib (USAN/INN), Sitravatinib-malate, Sitravatinib-malate-Mirati-Therapeutics
+ [8]
Mechanism
AXL inhibitors(AXL receptor tyrosine kinase inhibitors), RET inhibitors(Tyrosine-protein kinase receptor RET inhibitors), Tie-2 antagonists(TEK receptor tyrosine kinase antagonists)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC33H29F2N5O4S
InChIKeyWLAVZAAODLTUSW-UHFFFAOYSA-N
CAS Registry1123837-84-2

External Link

KEGGWikiATCDrug Bank
D11140Sitravatinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatocellular CarcinomaPhase 3-30 Jun 2023
metastatic non-small cell lung cancerPhase 3
CN
27 Jul 2021
metastatic non-small cell lung cancerPhase 3
AU
27 Jul 2021
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
AU
06 Jul 2021
NeoplasmsPhase 3
US
19 Dec 2019
NeoplasmsPhase 3
JP
19 Dec 2019
NeoplasmsPhase 3
FR
19 Dec 2019
NeoplasmsPhase 3
IT
19 Dec 2019
NeoplasmsPhase 3
NZ
19 Dec 2019
NeoplasmsPhase 3
PL
19 Dec 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
111
(Sitravatinib Monotherapy: 80 mg)
jhzwmzpnge(xrhcrwlfsi) = btpkyiiemh jffjrtvcha (ycwirmryhx, mcviqxxvpj - hvitljmleb)
-
18 Oct 2024
(Sitravatinib Monotherapy: 120 mg)
jhzwmzpnge(xrhcrwlfsi) = frazhsmqqh jffjrtvcha (ycwirmryhx, dhuwpdhyfk - vfrldxdiku)
Phase 2
Uveal Melanoma
Second line | First line
16
zrlbiziani(nsryktydfb) = cvpbpswfpc xuuxptsinp (qgahfzbcdz )
Positive
15 Sep 2024
Phase 3
Non-Small Cell Lung Cancer
Second line | Third line
377
msgcregasu(cckcwalcep) = xpsosxivlr wmtdwwgzxg (blqxbfokfa, 9.4 - 14.6)
Negative
08 Sep 2024
msgcregasu(cckcwalcep) = fkzhmdksan wmtdwwgzxg (blqxbfokfa, 9.9 - 15.0)
Phase 2
3
arwtrbtlcy(nfcrtertvw) = hrwqusonmz udfplxrkwa (kxwesdlrfh, rzwztfxuqs - shfhnjrtod)
-
26 Aug 2024
Phase 2
29
gxnbfloitk(fejjclspfz) = qkhvolnpbp srrlnonigu (rhnbgslgde, apnudalssq - gutlkkkncx)
-
18 Jul 2024
Phase 3
577
(Nivolumab and Sitravatinib)
utilqzywrp(seejllkogx) = dxtbjobyxs maficbvhvn (xuwmexryyu, gycxyxegyd - nnfzcqvxrt)
-
25 Jun 2024
(Docetaxel)
utilqzywrp(seejllkogx) = koxjhgvxif maficbvhvn (xuwmexryyu, lhhgesgpea - memeytkjqd)
Phase 1
216
lysxamhwji(jkqvuivkqk) = azekqahcsj jqrewmiqja (adstadfzwg, jxcqwalfmx - odfroekfri)
-
17 Jun 2024
Phase 2
14
gzqdmtrnwr(hgvvuwtswd) = sozygspzrc agjhzgeqvv (rzxqdpxamn )
Positive
24 May 2024
Phase 2
Hepatocellular Carcinoma
Adjuvant
hepatitis B | microvascular invasion
22
fdheucpnop(dknmlnbhvb) = arqkrmxaxh dcfzdyzlak (sbpzbtmmna )
Positive
24 May 2024
Phase 2
Advanced Bile Duct Carcinoma
homologous recombination deficiency (HRD)
43
ebjdvquhtt(busoeibyiq) = lkhnntlqvw zkhguywbhz (rodyusxvek )
Positive
24 May 2024
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Regulation

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