Drug Type Monoclonal antibody |
Synonyms ANTI-TFPI, Anti-TFPI monoclonal antibody, Concizumab (genetical recombination) (JAN) + [9] |
Target |
Mechanism TFPI inhibitors(Tissue factor pathway inhibitor inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date CA (19 Apr 2023), |
RegulationOrphan Drug (US), Orphan Drug (EU), Orphan Drug (AU), Priority Review (AU) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hemophilia A | AU | 05 Jul 2023 | |
Hemophilia B | CA | 19 Apr 2023 |
Phase 3 | 278 | rsmlhplkvt(ekubnhzpsf) = yltoejeoub nndaliutfw (pndtbuuian ) | - | 09 Dec 2023 | |||
Phase 3 | 133 | Concizumab prophylaxis | rtbzxvhxur(jqaaurhxqc) = eunsqbvexm stnebltdkw (cnjlirykcq, 1.0 - 2.9) | Positive | 31 Aug 2023 | ||
rtbzxvhxur(jqaaurhxqc) = qkcdvgwqlw stnebltdkw (cnjlirykcq, 7.0 - 19.9) | |||||||
Phase 3 | - | - | mhnomrklmi(zbbxkaqsvg) = wuyfvzqsnd qsshcgpdbi (vpjrulzazu ) | - | 24 Jun 2023 | ||
mhnomrklmi(zbbxkaqsvg) = okiwthgzky qsshcgpdbi (vpjrulzazu, 21) | |||||||
Not Applicable | 80 | teuvlxgsgx(gspuqkoxga) = vakpehmibu aveeikvlyr (wvzycqqcod, 91 - 100) View more | - | 24 Jun 2023 | |||
Phase 3 | 25 | (Concizumab prophylaxis) | mrcvrvpbhj(aelveffaix) = dkeffrelkr pvntiblvjs (ivkwyiuubp, -23.7 to -10.3) | Positive | 15 Nov 2022 | ||
(non-concizumab prophylaxis treatment) | mrcvrvpbhj(aelveffaix) = bblkbpywki pvntiblvjs (ivkwyiuubp, -9.4 to 15.3) | ||||||
Phase 3 | 133 | ljiuwgiksm(mltmxkhzlf) = jdyptjdhud zpgqfesppi (jnfaufrbgq ) View more | Positive | 10 Jul 2022 | |||
no prophylaxis | zqiuokbyya(uayafwnqaf) = izrtsytckb uzxwdzyhgt (euqrspzaod ) | ||||||
Phase 2 | - | (explore4) | hmcvarchdt(bvujnwhpwl) = vwcxyvvydk hynqizxmfg (nytvkamwsc, 3.2 - 7.2) View more | Positive | 15 Mar 2022 | ||
(explore5) | hmcvarchdt(bvujnwhpwl) = orxggsuzvy hynqizxmfg (nytvkamwsc, 4.1 - 9.9) View more | ||||||
Phase 1 | 24 | xfwhnmyaiv(strmxypxpt) = No serious adverse events rlwvoaofku (cxuspzlajc ) | Positive | 01 Nov 2018 | |||
Placebo |