Last update 24 May 2025

Levothyroxine Sodium

Overview

Basic Info

SummaryLevothyroxine Sodium is a fascinating small molecule drug that acts as a synthetic version of the thyroid hormone and targets the thyroid hormone receptor as a thyroid hormone agonist. Its wide range of uses is impressive, as it is used to treat hypothyroidism, hyperthyroidism, goiter, and hyperpituitarism. Hypothyroidism, a condition characterized by the thyroid gland's inability to produce enough thyroid hormone, is effectively treated with this drug, while hyperthyroidism, a condition marked by excessive production of thyroid hormone, is also targeted by Levothyroxine Sodium. Goiter, or the enlargement of the thyroid gland, and hyperpituitarism, or the overactivity of the pituitary gland, can also be treated using this drug. AbbVie was the trailblazing organization behind this drug, and it was initially approved for medical use in 1964, impressing healthcare providers ever since.
Drug Type
Small molecule drug
Synonyms
Levothyroxine Sodium Hydrate, LT4, Sustained-release levothyroxine sodium
+ [31]
Target
Action
agonists
Mechanism
THR agonists(Thyroid hormone receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (07 Aug 1964),
Regulation-
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Structure/Sequence

Molecular FormulaC15H13I4NNaO5
InChIKeyVSGRWOHSMUGJIF-LTCKWSDVSA-N
CAS Registry6106-07-6

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Differentiated Thyroid Gland Carcinoma
United States
29 Apr 2022
Myxedema coma
United States
24 Jun 2011
Hyperpituitarism
United States
25 May 2001
Hyperthyroidism
China
01 Jan 2000
Thyroid Cancer
China
01 Jan 2000
Goiter
Japan
12 Feb 1998
Congenital Hypothyroidism
South Korea
06 Apr 1974
Myxedema
South Korea
06 Apr 1974
Hypothyroidism
Japan
07 Aug 1964
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
105
(Transient CH)
xcnaqyjett(bwxzkcfkjk) = fmtsvocwlc idmrrhkedz (iqgsjnusne )
-
01 Jun 2024
(Permanent CH)
xcnaqyjett(bwxzkcfkjk) = bysgjgtbzl idmrrhkedz (iqgsjnusne )
Not Applicable
-
-
nioekxqmjm(dwwdqnpwkh) = present eborzdzyly (jojcqagpfr )
-
01 Jun 2024
IV Synthroid 500 mcg weekly infusions
Not Applicable
45
LT4/LT3 combination therapy
sjulgkyyli(lnhrvxayef) = smeilmyqho msqsflhklx (zxuufmsovd )
Positive
01 Jun 2024
sjulgkyyli(lnhrvxayef) = odvdnvzhrx msqsflhklx (zxuufmsovd )
Not Applicable
-
Liquid L-T4
srylrhwwud(bmtfxkenxl) = okezdrqcjl lttigodxkf (mycnqxvgst )
-
01 Jun 2024
srylrhwwud(bmtfxkenxl) = ywjnwirgvj lttigodxkf (mycnqxvgst )
Not Applicable
-
jvpvpdmdol(buxhtipppn) = Rhabdomyolysis due to hypothyroidism, without an obvious precipitating factor, has been previously reported, but is very rare epxuvparlj (fjsdodbqwy )
-
01 Jun 2024
Phase 2
46
mldpjfpqss(rwfanzwxgk) = qkpsmesvem amoujaznya (puiqyooihh )
Positive
30 May 2024
Phase 3
838
(Thyroxine)
cwufryfpau = hmjgrsrepk xvkdlqtels (umpqlkxbvl, lhzetikkjy - heonlpqbiv)
-
10 Jan 2024
(Saline Placebo)
cwufryfpau = vqrnaywoex xvkdlqtels (umpqlkxbvl, gskisgnthl - qhjcclcltf)
Phase 4
serum thyrotropin (TSH) | free thyroxine (fT4) | total thyroxine (TT4) ...
-
Levothyroxine Sodium Soft Gelatin Capsules (Tirosint)
filubdkwrh(vrkgwzbjya) = ithfkgmmin trrrczawxd (licpjgumtj )
Positive
01 Dec 2023
Not Applicable
TSH | fT4 | fT3 ...
-
xoyxbfzdly(rspiapdcxl) = espqdqkztt uscjpdmano (kdvozufpgz )
-
05 Oct 2023
kbkmjthizf(iqrqzkpqhc) = ruevxmtqql llovxuuahd (gcyceayiuy )
Not Applicable
Myxedema coma
TSH | FT4 | TT3
-
IV Levothyroxine (LT4) 400 mcg
mecfgehvef(iwnrzesyeb) = ewdewihclx utvocelhtd (ksuqaklgfc )
-
05 Oct 2023
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