Delving into the Latest Updates on Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid with Synapse

Primary objective: To evaluate the effectiveness of stannous galactosyl human serum albumin diethylenetriamine pentaacetate for injection in clinical liver function assessment; Secondary objective: To evaluate the safety of stannous galactosyl human serum albumin diethylenetriamine pentaacetate for injection in liver function assessment.

Start Date09 Jun 2021

Sponsor / Collaborator

Peking Union Medical College Hospital

[+1]

CTR20191555 / CompletedPhase 1

99mTc-GSA注射液在中国健康志愿者体内的药代动力学和安全性的I期临床研究

[Translation] Phase I clinical study on the pharmacokinetics and safety of 99mTc-GSA injection in Chinese healthy volunteers

主要目的：评估锝[99mTc]半乳糖酰人血清白蛋白二亚乙基三胺五乙酸盐（99mTc-GSA）注射液在健康志愿者体内的药代动力学特征；次要目的：评估锝[99mTc]半乳糖酰人血清白蛋白二亚乙基三胺五乙酸盐（99mTc-GSA）注射液单次给药在健康受试者中的安全性和耐受性。

[Translation]

Primary objective: To evaluate the pharmacokinetic characteristics of technetium [99mTc] galactosyl human serum albumin diethylenetriamine pentaacetate (99mTc-GSA) injection in healthy volunteers; Secondary objective: To evaluate the safety and tolerability of single-dose technetium [99mTc] galactosyl human serum albumin diethylenetriamine pentaacetate (99mTc-GSA) injection in healthy subjects.

Start Date29 Nov 2019

Sponsor / Collaborator

Peking Union Medical College Hospital

[+1]

JPRN-UMIN000035026 / RecruitingIIT

Predictive of liver function after Stereotactic body radiotherapy using 99mTc-GSA hepatobiliary schinchigraphy - Predictive of liver function after SBRT using hepatobiliary schinchigraphy

Start Date27 Nov 2018

Sponsor / Collaborator

Asahi University

100 Clinical Results associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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100 Translational Medicine associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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100 Patents (Medical) associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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278

Literatures (Medical) associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

01 Dec 2024·International Journal of Biological Macromolecules

Fabrication and characterization of double-layer active intelligent film based on chitosan, polyvinyl alcohol, grape skin anthocyanin and selenium nanoparticle

Article

Author: Zhu, Zhenzhou ; Xiang, Hongxia ; Cong, Xin ; Chen, Xiang ; Cheng, Shuiyuan ; Xiao, Naiyu ; Li, Shuyi ; Chen, Xu

This study involved the fabrication of double-layer intelligent films using chitosan (CS), polyvinyl alcohol (PVA), grape skin anthocyanin (GSA), gellan gum (GG) and selenium nanoparticles (SeNPs). The CS/PVA/GSA layer functioned as the internal indicator layer, and the GG/SeNPs layer acted as the external layer for antioxidant and antimicrobial purposes. SEM, FTIR, XRD, and TGA results confirmed the successful fabrication of double-layer films as well as the presence of hydrogen bonding interaction between the two layers. The tensile strength of double-layer films (8.06 MPa-9.61 MPa) fallen between that of single-layer CS/PVA/GSA film (12.51 MPa) and GG/SeNPs film (1.50 MPa-7.67 MPa). The double-layer films demonstrated good UV-blocking abilities, as well as outstanding antioxidant (ABTS scavenging rate can be up to ∼80 %) and antimicrobial properties. Compared with single-layer CS/PVA/GSA film, the double-layer film incorporated with 6.6 wt% SeNPs (CPG/GS2 film) possessed a more rapid and stronger response towards NH₃/acetic acid as well as enhanced storage stability. Furthermore, the CPG/GS2 film can increase the shelf life of strawberries at 25 °C by 4 days, and its visible color change showed strong correlation with the weight loss rate (R² = 0.99) and hardness (R² = 0.98) of strawberries.

01 Dec 2024·Computer Methods and Programs in Biomedicine

ECG classification based on guided attention mechanism

Article

Author: Cai, Wenjie ; Liu, Wenjing ; Huang, Yangcheng ; Yin, Ziyi ; Wang, Mingjie ; Hu, Shuaicong

BACKGROUND AND OBJECTIVEIntegrating domain knowledge into deep learning models can improve their effectiveness and increase explainability. This study aims to enhance the classification performance of electrocardiograms (ECGs) by customizing specific guided mechanisms based on the characteristics of different cardiac abnormalities.METHODSTwo novel guided attention mechanisms, Guided Spatial Attention (GSA) and CAM-based spatial guided attention mechanism (CGAM), were introduced. Different attention guidance labels were created based on clinical knowledge for four ECG abnormality classification tasks: ST change detection, premature contraction identification, Wolf-Parkinson-White syndrome (WPW) classification, and atrial fibrillation (AF) detection. The models were trained and evaluated separately for each classification task. Model explainability was quantified using Shapley values.RESULTSGSA improved the F1 score of the model by 5.74%, 5%, 8.96%, and 3.91% for ST change detection, premature contraction identification, WPW classification, and AF detection, respectively. Similarly, CGAM exhibited improvements of 3.89%, 5.40%, 8.21%, and 1.80% for the respective tasks. The combined use of GSA and CGAM resulted in even higher improvements of 6.26%, 5.58%, 8.85%, and 4.03%, respectively. Moreover, when all four tasks were conducted simultaneously, a notable overall performance boost was achieved, demonstrating the broad adaptability of the proposed model. The quantified Shapley values demonstrated the effectiveness of the guided attention mechanisms in enhancing the model's explainability.CONCLUSIONSThe guided attention mechanisms, utilizing domain knowledge, effectively directed the model's attention, leading to improved classification performance and explainability. These findings have significant implications in facilitating accurate automated ECG classification.

01 May 2024·Pharmaceutical Research

The Use of Global Sensitivity Analysis to Assess the Oral Absorption of Weakly Basic Compounds: A Case Example of Dipyridamole

Article

Author: Ibrahim, Fady ; Louit, Guillaume ; Kesharwani, Siddharth S

OBJECTIVETo utilize the global system analysis (GSA) in oral absorption modeling to gain a deeper understanding of system behavior, improve model accuracy, and make informed decisions during drug development.METHODSGSA was utilized to give insight into which drug substance (DS), drug product (DP), and/or physiological parameter would have an impact on peak plasma concentration (C_max) and area under the curve (AUC) of dipyridamole as a model weakly basic compound. GSA guided the design of in vitro experiments and oral absorption risk assessment using FormulatedProducts v2202.1.0. The solubility and precipitation profiles of dipyridamole in different bile salt concentrations were measured. The results were then used to build a mechanistic oral absorption model.RESULTSGSA warranted further investigation into the precipitation kinetics and its link to the levels of bile salt concentrations. Mechanistic modeling studies demonstrated that a precipitation-integrated modeling approach appropriately predicted the mean plasma profiles, C_max, and AUC from the clinical studies.CONCLUSIONSThis work shows the value of GSA utilization in early development to guide in vitro experimentation and build more confidence in identifying the critical parameters for the mathematical models.

100 Deals associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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R&D Status

Approved

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Indication	Country/Location	Organization	Date
Diagnostic agents	JP	Nihon Medi-Physics Co., Ltd.	03 Jul 1992

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Diagnostic agents	Preclinical	CN	Peking Union Medical College Hospital	09 Jun 2021
Diagnostic agents	Preclinical	CN	Beijing Shihong Pharmaceutical Co., Ltd.	09 Jun 2021
Contrast agents	Preclinical	CN	Chinese Academy of Medical Sciences	24 Mar 2021
Contrast agents	Preclinical	CN	Beijing Shihong Pharmaceutical Co., Ltd.	24 Mar 2021

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SNMMI2016	Not Applicable	-	-	99mTc-GSA (Normal group)	fqluugazmi(kcfzmnsjcg) = srmzbxyixe dtrllygemq (qafmlvwtpu, 5.1)	-	24 May 2016
				99mTc-GSA (Mild liver dysfunction group)	fqluugazmi(kcfzmnsjcg) = xgrjxyzsmb dtrllygemq (qafmlvwtpu, 4.4)