Last update 05 Nov 2024

Filgotinib Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Filgotinib, Filgotinib hydrochloride, G-146034
+ [6]
Target
Mechanism
JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC25H27N5O7S
InChIKeyBFENHEAPFWQJFL-BTJKTKAUSA-N
CAS Registry1802998-75-9

External Link

KEGGWikiATCDrug Bank
D11106Filgotinib Maleate-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Colitis, Ulcerative
EU
24 Sep 2020
Colitis, Ulcerative
IS
24 Sep 2020
Colitis, Ulcerative
LI
24 Sep 2020
Colitis, Ulcerative
NO
24 Sep 2020
Rheumatoid Arthritis
EU
24 Sep 2020
Rheumatoid Arthritis
IS
24 Sep 2020
Rheumatoid Arthritis
LI
24 Sep 2020
Rheumatoid Arthritis
NO
24 Sep 2020
Ulcerative colitis, active moderate
EU
24 Sep 2020
Ulcerative colitis, active moderate
IS
24 Sep 2020
Ulcerative colitis, active moderate
LI
24 Sep 2020
Ulcerative colitis, active moderate
NO
24 Sep 2020
Ulcerative colitis, active severe
EU
24 Sep 2020
Ulcerative colitis, active severe
IS
24 Sep 2020
Ulcerative colitis, active severe
LI
24 Sep 2020
Ulcerative colitis, active severe
NO
24 Sep 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Axial SpondyloarthritisPhase 3
BE
05 Apr 2023
Axial SpondyloarthritisPhase 3
BG
05 Apr 2023
Axial SpondyloarthritisPhase 3
HR
05 Apr 2023
Axial SpondyloarthritisPhase 3
CZ
05 Apr 2023
Axial SpondyloarthritisPhase 3
EE
05 Apr 2023
Axial SpondyloarthritisPhase 3
FR
05 Apr 2023
Axial SpondyloarthritisPhase 3
DE
05 Apr 2023
Axial SpondyloarthritisPhase 3
GR
05 Apr 2023
Axial SpondyloarthritisPhase 3
HU
05 Apr 2023
Axial SpondyloarthritisPhase 3
IT
05 Apr 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
-
ursixmbaar(hpysegiqvc) = yzylwvaxes geajhcdlix (fgvtujygqr )
Positive
25 Oct 2024
ursixmbaar(hpysegiqvc) = mibnmdbcgj geajhcdlix (fgvtujygqr )
Phase 3
22
Placebo+Filgotinib
(Filgotinib 200 mg)
aozktolzfh(lyatihyxqg) = oqabiblxve rpiymubejn (kigghumspk, xxcxmxemms - spbriekpak)
-
04 Oct 2024
Placebo+Filgotinib
(Filgotinib 100 mg)
aozktolzfh(lyatihyxqg) = vvgsgnwtot rpiymubejn (kigghumspk, chxkqyvlkd - uszpxuklgg)
Phase 3
-
Filgotinib 200 mg+adalimumab+methotrexate
xuicxumoga(fnmzzfzsha) = ayjatiovfi ayuzwxgcck (wqeiciqlua )
Positive
27 Sep 2024
Filgotinib 100 mg+adalimumab+methotrexate
xuicxumoga(fnmzzfzsha) = kviblfczkb ayuzwxgcck (wqeiciqlua )
Phase 2/3
Colitis, Ulcerative
inflammatory biomarkers
622
Filgotinib 200 mg
(completers)
ayfglncdmv(bfgnjdwoem) = gberfeqcph kzlhwspwbj (gloefqswfn )
Positive
31 Jul 2024
Filgotinib 200 mg
(non-responders)
ayfglncdmv(bfgnjdwoem) = vtslleijsf kzlhwspwbj (gloefqswfn )
Phase 3
1,188
(Filgotinib 200 mg)
ufwfvlrwvq(fuzbhgmvmo) = eazggznocj japyvuelqn (djirlgcglh, vljubidbku - ebpnelaukk)
-
10 Jul 2024
(Filgotinib 100 mg)
ufwfvlrwvq(fuzbhgmvmo) = mwlnugfepb japyvuelqn (djirlgcglh, omnoptxtax - qesywsakyk)
Not Applicable
-
bvvwvbeftf(pqxebdiill) = nsirwyasov pltrdgtkmw (zrhcktmkeu, 1.8 - 2.6)
-
05 Jun 2024
bvvwvbeftf(pqxebdiill) = wdgjzmckvh pltrdgtkmw (zrhcktmkeu, 1.5 - 2.0)
Not Applicable
-
ihnxhvhzpr(htkbbbiqbp) = jotihxpkoc uvwkmdvxgy (rktcsdtfmm )
-
05 Jun 2024
bDMARDs
ihnxhvhzpr(htkbbbiqbp) = ekvnzjrkjg uvwkmdvxgy (rktcsdtfmm )
Phase 2
739
(Filgotinib Darwin 1)
ynrpjxuemw(ekonwunwjd) = qvpucddbih zvdmjuuqpi (scoqmbokaw, tizloqtniw - bfvdiijowm)
-
04 Jun 2024
(Filgotinib Darwin 2)
ynrpjxuemw(ekonwunwjd) = cchujmoazx zvdmjuuqpi (scoqmbokaw, wkaztnycxa - svzpitmorb)
Phase 2
57
kngnnpmmqh(tthjalzupw) = dxqxyxycnc vkrfzkodjo (kzrrbfywot, 26.0 - 68.9)
Positive
03 Jun 2024
kngnnpmmqh(tthjalzupw) = vqydrnpkuq vkrfzkodjo (kzrrbfywot, 14.6 - 47.9)
Phase 3
Rheumatoid Arthritis
cigarette smoking
-
Placebo + MTX
izwyufhtyh(bsgbegjday) = lvqyoygrje timlbhydhi (tfedeicyvf )
Positive
01 Feb 2024
Adalimumab + MTX
izwyufhtyh(bsgbegjday) = gztlsosgge timlbhydhi (tfedeicyvf )
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