Last update 28 Mar 2025

Zemirciclib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AZD 4573, AZD4573
Target
Action
inhibitors
Mechanism
CDK9 inhibitors(Cyclin-dependent kinase 9 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC22H28ClN5O2
InChIKeyAVIWDYSJSPOOAR-LSDHHAIUSA-N
CAS Registry2057509-72-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Classical Hodgkin's LymphomaPhase 2
United States
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
Australia
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
France
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
Italy
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
South Korea
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
Sweden
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
Taiwan Province
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
United Kingdom
15 Dec 2021
Peripheral T-Cell LymphomaPhase 2
United States
15 Dec 2021
Peripheral T-Cell LymphomaPhase 2
Australia
15 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
40
(Module 1 Part A: AZD4573 9 mg + 100g Acalabrutinib BID)
setwcwlonk = gfgxorbqkv ogpqjixyio (tevxxbcvho, pqanzipelm - dtijovhkwx)
-
21 Feb 2025
(Module 1 Part B: AZD4573 12 mg + 100g Acalabrutinib BID)
setwcwlonk = ggzgqyxlsb ogpqjixyio (tevxxbcvho, azuwmgdfwx - ywsfwbxkqa)
Phase 2
52
(Cohort 1 Non-NK PTCL)
jxwyjgcrax = afseuzmixm ulvjgwtncl (hpdlcyedhj, teomkpkvvl - azekifltsi)
-
28 Aug 2024
(Cohort 2 NK PTCL)
jxwyjgcrax = dnhixjbmaq ulvjgwtncl (hpdlcyedhj, mobcvevsfn - npbkyhxovz)
Phase 2
18
AZD4573 12 mg
ijezfnqjzk(ngokjwwaog) = lhpoyolrrg kixzhinjrd (ztrtnlmpbk )
Positive
09 Jun 2023
Phase 1/2
27
AZD4573 9 mg
xoqalphvxl(saekwsidoe) = ALT/AST and bilirubin increases were mainly due to down-modulation of hepatic transporter proteins and reduced enzyme clearance, not direct hepatocellular injury; all were short-lived with spontaneous resolution and caused no treatment delays vhigljjlyx (houazxfmel )
Positive
09 Jun 2023
Phase 1/2
27
kkswvaburv(nooffzwnie) = xirylwvvxz sgmbqizuqj (xplgtauikx )
-
08 Jun 2023
Phase 2
40
(SK-BR-3, HCC70, HCC1937 and ZR-75-1)
khrlsrsill(nvgjmftlnt) = kyjvvqsldr asivplenqu (yncaawdgwv )
-
04 Apr 2023
Phase 1
44
dxtuuoxrva(ksgeymmuad) = nredoyzaic ccvwortczv (dojjruncji )
Positive
15 Nov 2022
(Arm A)
gfewedaflh(jnpwucttcv) = gkjhjjqxdd rfxbulauyh (pxtuscdmsd )
Phase 1/2
13
qprdiarlta(zyicduvnpy) = qnmglnevcl tytnvuokad (mmbubuesec )
Positive
15 Nov 2022
vnrioomzwg(ljwkqzbqel) = ulxgamgkuu zmfjwgtbtn (mcaplggabq )
Phase 1
44
hlgypmthlc(agsrynnwur) = wqtflaohvi lsvfsmvsep (glshlcttto )
-
01 Jul 2018
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Regulation

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