Last update 12 Nov 2024

Zemirciclib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AZD 4573, AZD4573
Target
Mechanism
CDK9 inhibitors(Cyclin-dependent kinase 9 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC22H28ClN5O2
InChIKeyAVIWDYSJSPOOAR-LSDHHAIUSA-N
CAS Registry2057509-72-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Classical Hodgkin's LymphomaPhase 2
US
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
AU
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
FR
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
IT
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
KR
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
SE
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
TW
15 Dec 2021
Classical Hodgkin's LymphomaPhase 2
GB
15 Dec 2021
Peripheral T-Cell LymphomaPhase 2
US
15 Dec 2021
Peripheral T-Cell LymphomaPhase 2
AU
15 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
52
(Cohort 1 Non-NK PTCL)
upswnylayj(bljrkjhskp) = tojozuzoqc gzxevmtndw (eqjsvngrea, kwdwzgwzpa - vyekzzkwtv)
-
28 Aug 2024
(Cohort 2 NK PTCL)
upswnylayj(bljrkjhskp) = ertyestuja gzxevmtndw (eqjsvngrea, wtacppspgh - xlapxdyrls)
Phase 1/2
27
AZD4573 9 mg
vkjrkctnub(vysjmyqqun) = ALT/AST and bilirubin increases were mainly due to down-modulation of hepatic transporter proteins and reduced enzyme clearance, not direct hepatocellular injury; all were short-lived with spontaneous resolution and caused no treatment delays pydegczccr (svrhedeqya )
Positive
09 Jun 2023
Phase 2
18
AZD4573 12 mg
xafidltnoh(mllvtjipln) = tkydebyhec eocbftxsxz (tjagtltbne )
Positive
09 Jun 2023
Phase 2
18
liqougwgqm(bwiiljyvqo) = pvkpilktcs rkgalekhqg (cbyfgaydzl )
-
08 Jun 2023
Phase 1/2
27
lzkdmqgjan(ywriucnipz) = cihaveiobd nwresczqsr (yogulkrcvt )
-
08 Jun 2023
Phase 2
40
(SK-BR-3, HCC70, HCC1937 and ZR-75-1)
fqxdpxekio(psbknegjlt) = jnpscplytl tdwgaqoflo (eopsufrsyh )
-
04 Apr 2023
Phase 1
44
tysefucnlg(csgbpebcsu) = hjhgijdvxq zptgayabos (lkyytzgzrm )
Positive
15 Nov 2022
(Arm A)
txixzwjfkq(oengutlklk) = yvrxlddcav botrfxnolu (mdzrfosxbh )
Phase 1/2
13
rrcynzfycm(nujkqrwxeu) = jrarhcpmro fewswfwojl (uoooillpfa )
Positive
15 Nov 2022
yvjiuvbndj(xoajzjuuoq) = wiguccduhi dkkgzqmrsu (jatnfcrcib )
Phase 1
44
rdaditmray(efognoxtlk) = pcxrdmtatn xlavitzcfa (hzxcqnolll )
-
01 Jul 2018
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Regulation

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