Last update 30 Jun 2024

Mecamylamine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mecamylamine, Mecamylamine hydrochloride (USP), AGI-004
+ [6]
Target
Mechanism
AChR antagonists(Acetylcholine receptor; alpha1/beta1/delta/gamma antagonists)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseWithdrawn
First Approval Date
US (01 Mar 1956),
Regulation-
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Structure

Molecular FormulaC11H22ClN
InChIKeyPKVZBNCYEICAQP-UHFFFAOYSA-N
CAS Registry826-39-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
US
01 Mar 1956
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 2
US
01 Jun 2008
Depressive Disorder, MajorPhase 2
IN
01 Jun 2008
Dystrophy, MacularPhase 2-01 May 2008
Diabetic macular oedemaPhase 2
US
01 Sep 2007
Wet age-related macular degenerationPhase 2
BR
01 Mar 2007
Wet age-related macular degenerationPhase 2
CZ
01 Mar 2007
Wet age-related macular degenerationPhase 2
MX
01 Mar 2007
Wet age-related macular degenerationPhase 2
PL
01 Mar 2007
Wet age-related macular degenerationPhase 2
RU
01 Mar 2007
Wet age-related macular degenerationPhase 2
UA
01 Mar 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
21
Placebo
(Placebo)
bbtgfzepet(byudzgslrz) = vzqgxbazth glhwtzwadg (ijkccbploo, pffjyatjtk - hvtdxzixyb)
-
18 Apr 2016
(Mecamylamine)
bbtgfzepet(byudzgslrz) = mpfusymyrq glhwtzwadg (ijkccbploo, guxayxlntq - cnnohbnukl)
Phase 1
20
Placebo
ssuqzfylhu(qimcvgkeoe) = constipation eimzpuhdka (mtgznkjeoz )
Negative
01 Jun 2012
Phase 2
343
(1% Mecamylamine)
frefqjtuom(arxzajaxlj) = kwjosdhpnz tcvqzzgjvz (sklfruplrp, sqhwkvanhs - souwtuvfnq)
-
23 Nov 2010
(0.3% Mecamylamine)
frefqjtuom(arxzajaxlj) = qmnzvylqmw tcvqzzgjvz (sklfruplrp, cbkzaqiwwl - nadtawbmlb)
Phase 1/2
-
zruztnynka(cdegquqval) = kwxpuhxghi gdvxwvcgmv (srtxmpqlqt )
-
01 May 2010
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Regulation

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