Phase II/III to evaluate the safety and efficacy of Thai Red Cross Society fibrin sealant compared with commercially available fibrin sealant (TISSEEL) in post-operative air leak. A randomized controlled trial

Start Date01 Nov 2024

Sponsor / Collaborator

Health Systems Research Institute

TCTR20240723010

/ RecruitingPhase 2/3IIT

Phase II/III open-label randomized-controlled trial to evaluate the safety and efficacy of Fibrin sealant Thai Red Cross Society compared with commercially available fibrin sealant (TISSEEL) in pterygium volunteer

Start Date09 Oct 2024

Sponsor / Collaborator

Health Systems Research Institute

CTRI/2023/06/053870

/ Not yet recruitingPhase 2IIT

Randomised controlled trial comparing the efficacy of autologous platelet rich fibrin therapy versus hydrocolloid gel dressing in chronic non-healing cutaneous ulcers, an open label study from Eastern India.

Start Date30 Jun 2023

Sponsor / Collaborator-

100 Clinical Results associated with Fibrin Sealant (Baxter)

100 Translational Medicine associated with Fibrin Sealant (Baxter)

100 Patents (Medical) associated with Fibrin Sealant (Baxter)

319

Literatures (Medical) associated with Fibrin Sealant (Baxter)

01 Sep 2025·Acta Biomaterialia

Chlorocatechol-functionalized gelatin nanoparticles as a hemostatic agent with antimicrobial properties

Article

Author: Wang, Kan ; Razaviamri, Fatemeh ; Lee, Bruce P ; Manuel, James ; Zhang, Zhongtian

Hemorrhage is one of the leading preventable causes of death associated with trauma, which is often complicated by wound infection. Current hemostatic materials are not ideal and lack antimicrobial properties needed for infection prevention. Here, we tested the feasibility for 6-chlorodopamine-functionalized gelatin (GDC) nanoparticles to function as a hemostatic powder with strong tissue adhesion and antibacterial properties. 6-Chlorodopamine contains a catechol sidechain that is further modified with an electron withdrawing chlorine atom, and provides strong tissue adhesion and antimicrobial property. These gelatin nanoparticles are not covalently crosslinked, which enablde them to rapidly transition into an adhesive film when hydrated with an aqueous solution or blood. The chlorination of catechol significantly increased structural integrity, interfacial bonding to tissue surface, and the rate of film formation. Additionally, GDC nanoparticles are noncytotoxic and nonhemolytic, and effectively killed Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Finally, GDC nanoparticles achieved significantly faster hemostasis and reduced blood loss when compared to a commercial fibrin glue, Tisseel, in tail transection and liver hemorrhage models performed in mice. These findings highlight the potential of GDC nanoparticle as a versatile, multifunctional hemostatic agent capable of both rapid hemorrhage control and infection prevention. STATEMENT OF SIGNIFICANCE: Existing hemostatic agents often lack effective antimicrobial properties and may not be suited for application in a prehospital setting. This work evaluated a multifunctional, hemostatic nanoparticle that addresses key challenges in hemorrhage control and infection prevention, through a simple, bioinspired formulation. Gelatin nanoparticles were functionalized with chlorocatechol (GDC) that can rapidly transition into adhesive films when hydrated with blood. Chlorocatechol imparted the nanoparticles with strong tissue adhesion, film integrity, and antimicrobial property. In mouse hemorrhage models, GDC significantly reduced blood loss and bleeding time when compared to a commercial fibrin sealant. This powder-form material requires no mixing or specialized equipment to deploy, which makes it potentially suitable for application in a prehospital setting.

16 Jul 2025·Cureus Journal of Medical Science

Sequential Surgical Management of a Recurrent Complex Transsphincteric Anal Fistula With Sphincter Disruption: A Case Report

Article

Author: Abarca-Magallón, Alfredo Sinahi ; Pérez-Valdez, Diego ; Valdivieso-Siguenza, Daniel Alejandro ; Hernández-Alvarado, Samuel ; Castañeda-Rodríguez, Daniel

High transsphincteric anal fistulas represent a significant therapeutic challenge due to the risk of fecal incontinence associated with division of the sphincter complex. Management must be individualized, particularly in recurrent cases. We report the case of a 55-year-old male with a recurrent high posterior transsphincteric anal fistula who had undergone multiple previous surgical interventions. Initial treatment with fistulectomies and cryptectomies resulted in disruption of both the internal and external anal sphincters, leading to severe fecal incontinence. Due to persistent fistulous drainage, the patient underwent diagnostic laparoscopy with creation of a protective loop ileostomy, irrigation and drainage of the tract, primary transanal closure of the internal opening, and application of fibrin sealant (Tisseel^®, Baxter Healthcare Corporation, Deerfield, IL). In the outpatient setting, tract curettage using a CitoBrush^® (Medscand AB, Malmö, Sweden) and repeat application of fibrin sealant were performed. Subsequent examination under anesthesia revealed fibrosis without evidence of an active tract. Intestinal continuity was ultimately restored. The patient's postoperative course was favorable, with no recurrence or continence impairment. This case illustrates the importance of a stepwise surgical approach integrating conventional and adjunctive techniques for the treatment of complex anal fistulas. The combined use of sphincteroplasty, temporary fecal diversion, and biological sealants provided effective disease control while preserving sphincter function. Current evidence supports the use of fibrin sealants as adjuncts in fibrotic tracts and the role of temporary diversion in cases involving sphincter disruption. Sequential and patient-specific surgical management led to successful resolution of the fistula without compromising continence. This multidisciplinary strategy may be considered in patients with complex anatomy and a history of multiple surgical failures.

25 Jun 2025·Cureus Journal of Medical Science

Evaluating the Utility of Topical Haemostatic Adjuncts in Transoral Robotic Surgery (TORS)

Article

Author: Ahsan, Syed Farhan ; Sattar, Zakariya ; Watts, Emma

INTRODUCTION:

Transoral robotic surgery (TORS) is a minimally invasive modern surgical technique, offering novel access to the oral cavity with important implications for the management of oropharyngeal squamous cell carcinoma. However, TORS carries complications including haemorrhage, pain and impaired swallowing, with potentially significant implications for patients and healthcare systems.

AIM:

This combined retrospective cohort study and literature review aims to explore our experience with the use of topical haemostatic products in TORS to improve post-operative outcomes.

METHODS:

We analysed our experience with the use of three different topical haemostatic adjuncts during TORS procedures at a major head and neck cancer centre from October 2023 to August 2024. The primary outcome measure was the rate of post-operative haemorrhage. This cohort study was complemented by a systematic review of the existing literature regarding the use of topical haemostatic products in TORS.

RESULTS:

Eighteen patients met criteria for inclusion. The type of topical haemostatic adjunct used varied between Tisseel (n=8, 44.4%), Floseal (n=4, 22.2%) and Purabond (n=6, 33.3%). One patient (5.6%) developed a secondary post-operative haemorrhage. Another patient (n=1, 5.6%) required admission for management of post-operative pain. Our experience provides preliminary insight into the utility of topical haemostatic adjuncts in TORS and underlines the need for further research in this area.

CONCLUSION:

Topical haemostatic adjuncts, in our view, are useful, surgeon-friendly products that may augment haemostasis in TORS. Further studies are required to determine the efficacy of individual topical haemostatic products in preventing post-operative haemorrhage and enhancing recovery following TORS.

News (Medical) associated with Fibrin Sealant (Baxter)

30 Jan 2024

·www.biospace.com

RION Announces Initiation of Phase 2A Clinical Study for Purified Exosome Product™ (PEP™) in Diabetic Foot Ulcers

RION's Phase 2A clinical trial focuses on evaluating the safety and efficacy of Platelet Exosome Product™ (PEP™) combined with TISSEEL fibrin sealant for treating Diabetic Foot Ulcers (DFU). Diabetic Foot Ulcers, affecting 18.6 million people worldwide each year, significantly impact quality of life and impose substantial economic burdens on healthcare systems. The trial is a key part of RION's broader efforts in regenerative medicine, aiming to address unmet needs in the treatment of chronic conditions such as DFU. ROCHESTER, Minn.--(BUSINESS WIRE)-- RION, a clinical-stage regenerative medicine company, at the forefront of the exosome therapeutic revolution, has officially commenced a Phase 2A study aimed at assessing the efficacy and safety of its exclusive exosome regenerative therapeutic, known as Purified Exosome Product™ (PEP™), for the management of Diabetic Foot Ulcers (DFU). This press release features multimedia. View the full release here: RION, located in Rochester, MN, is internationally recognized for its pioneering advancements in isolating and mass-producing platelet-derived exosomes. (Photo: Business Wire) Diabetic Foot Ulcers affect approximately 18.6 million people worldwide each year1 and are associated with increasing rates of amputation and death. The economic burden of DFUs is substantial, imposing $13 billion in cost on the US public and private healthcare systems.2 The trial is a key part of RION's broader efforts in regenerative medicine, aiming to address unmet needs in the treatment of chronic conditions such as DFU. Building on the success of the Phase 1B study conducted at Mayo Clinic, RION's Phase 2A trial represents a significant step forward in the development of a regenerative biologic for Diabetic Foot Ulcers. This prospective, randomized, multi-center study will involve 40 patients across the United States. Patients will be divided into two cohorts: one receiving standard care and the other treated with PEP™ exosomes, enabling a thorough comparison of outcomes. A positive outcome in the Phase 2A trial has the potential to pave the way for a pivotal study followed by the submission of a Biologics License Application (BLA). PEP™ addresses a significant unmet medical need in the realm of diabetic wound care. Dr. Atta Behfar, Co-founder of RION, said, “The progress we've made in advancing PEP™, reflects our deep commitment to developing powerful exosome therapies that unleash the body’s ability to heal from within. Not only will this study address a critical unmet need in chronic wound care, but it’s a pivotal moment for RION. We are disrupting the boundaries of exosome technology, to develop a new generation of therapies endowed with the potential to truly transform the way we treat complex and incurable diseases.” In the United States, the treatment of DFUs remains a significant challenge in the medical community, with no new biologics approved by the US FDA for diabetic wounds since the late 1990s3. RION is committed to bringing exosome-based therapies to patients as quickly and safely as possible to transform the management and outcomes of this devastating condition. About RION RION was born out of the Mayo Clinic after two decades of research and innovation at that institution. RION is located in Rochester, MN and is internationally recognized for its pioneering advancements in isolating and mass-producing platelet-derived regenerative exosomes into shelf stable PEP™. RION is rewriting the regenerative medicine playbook. Our cutting-edge proprietary biomanufacturing platform crafts the future of regenerative therapy, unlocking the potent secrets within these tiny cellular messengers. RION’s regenerative PEP™ technology will be integral to the therapeutic exosome revolution. About PEP™ RION's Purified Exosome Product™ (PEP™) is a shelf stable product in a lyophilized powder derived from human platelets that contains stabilized platelet-derived regenerative exosomes. PEP™ is an exosome therapeutic that is designed to promote cell growth and formation of new blood vessels, while also reducing inflammation and protecting cells. RION and its scientific collaborators have performed extensive research showing the potential of PEP™ to heal a wide array of damaged tissue. The company is currently evaluating PEP™ in preclinical and clinical studies for several indications. While our focus remains on wound healing, multiple IND-enabling efforts in musculoskeletal, cardiovascular disease, pulmonary disease and women’s health disorders are creating new solutions where current standards of care cannot address unmet clinical needs. About Diabetic Foot Ulcers (DFU) Diabetic foot ulcers (DFUs) are not just wounds. These slow-healing sores on the feet are a brutal consequence of diabetes, inflicting a triple threat: excruciating pain, crippling mobility, and the specter of amputation. The numbers paint a grim picture. Up to 25% of people with diabetes will face a DFU in their lifetime4, and for almost a quarter of them also limb amputation5. In fact, every three and a half minutes in the US, a DFU becomes an amputation6. This isn't just a statistic, it's a story of lives shattered, livelihoods lost, and families forever changed. Many patients endure the agony of recurrences, their lives trapped in a cycle of healing and reopening wounds. And sadly, the shadow of mortality looms large. 40% of DFU sufferers will succumb to the condition7, making it a pervasive silent killer of diabetic communities. The economic cost is equally staggering. DFUs drain healthcare systems, piling on direct treatment expenses and crippling indirect costs from lost productivity and long-term disability. RION's journey is paved with unwavering determination. We seek to break the cycle of pain, loss, and economic burden through application of our next-generation regenerative exosome technology. We will remain undeterred in our pursuit to have PEP™ become the first biologic to be approved for the treatment of DFU in over 25 years. References 1. Armstrong DG, Tan TW, Boulton AJM, Bus SA. Diabetic Foot Ulcers: A Review. JAMA. 2023 Jul 3;330(1):62-75. doi: 10.1001/jama.2023.10578. PMID: 37395769; PMCID: PMC10723802. 2. Rice JB, Desai U, Cummings AK, Birnbaum HG, Skornicki M, Parsons NB. Burden of diabetic foot ulcers for medicare and private insurers. Diabetes Care. 2014;37(3):651-8. doi: 10.2337/dc13-2176. Epub 2013 Nov 1. Erratum in: Diabetes Care. 2014 Sep;37(9):2660. PMID: 24186882. 3. Fang RC, Galiano RD. A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Biologics. 2008 Mar;2(1):1-12. doi: 10.2147/btt.s1338. PMID: 19707423; PMCID: PMC2727777. 4. Yazdanpanah L, Shahbazian H, Nazari I, Arti HR, Ahmadi F, Mohammadianinejad SE, Cheraghian B, Hesam S. Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)-Two-Year Follow-Up Study. Int J Endocrinol. 2018 Mar 15;2018:7631659. doi: 10.1155/2018/7631659. PMID: 29736169; PMCID: PMC5875034. 5. Liao X, Li SH, El Akkawi MM, Fu XB, Liu HW, Huang YS. Surgical amputation for patients with diabetic foot ulcers: A Chinese expert panel consensus treatment guide. Front Surg. 2022 Nov 8;9:1003339. doi: 10.3389/fsurg.2022.1003339. PMID: 36425891; PMCID: PMC9679004. 6. Amputation Prevention Alliance. (n.d.). Amputation prevention alliance. Amputation Prevention Alliance | ADA. 7. Jeyaraman K, Berhane T, Hamilton M, Chandra AP, Falhammar H. Mortality in patients with diabetic foot ulcer: a retrospective study of 513 cases from a single Centre in the Northern Territory of Australia. BMC Endocr Disord. 2019 Jan 3;19(1):1. doi: 10.1186/s12902-018-0327-2. PMID: 30606164; PMCID: PMC6318899.

Phase 2Drug Approval

11 Jun 2022

·www.prnewswire.com

At 8.6% CAGR, Global Tissue Sealants and Tissue Adhesive Market Size & Share to Surpass USD 2.9 Billion by 2028 | Industry Trends, Growth, Value, Opportunities, Statistics, Analysis & Forecast Report by ZMR

NEW YORK, June 11, 2022 /PRNewswire/ -- As per the Zion Market Research study, The global tissue sealants and tissue adhesive market was worth around USD 1.5 billion in 2021 and is estimated to grow to about USD 2.9 billion by 2028, with a compound annual growth rate (CAGR) of approximately 8.6 percent over the forecast period. The report analyzes the tissue sealants and tissue adhesive market's drivers, restraints/challenges, and the effect they have on the demands during the projection period. In addition, the report explores emerging opportunities in the tissue sealants and tissue adhesive market. Key Industry Insights &Findings of the Tissue Sealants and Tissue Adhesive Market Reports: As per the analysis shared by our research analyst, the Tissue Sealants and Tissue Adhesive Market is expected to grow annually at a CAGR of around 8.6% (2022-2028). Through the primary research, it was established that the Cognitive and Memory Enhancer Drugs Market was valued at approximately USD 1.5Billion in 2021 and is projected to reach roughly USD 2.9 Billion by 2028. Large population and technical advancements, North America accounted for the largest share of tissue sealants and tissue adhesive. State-of-the-art medical research facilities and rising investments in healthcare infrastructure in this region, and also heightened understanding among both physicians & patients relating to therapeutic approaches, enhanced life expectancy, and a rising population will push growing demands for tissue sealants and tissue adhesives in the Asia Pacific region. Zion Market Research published the latest report titled " Tissue Sealants And Tissue Adhesive Market By Product (Natural Or Biological Sealants & Adhesives And Synthetic & Semi-Synthetic Adhesives), By Application (General Surgery, Orthopedic Surgery, Gynecology Surgery, Cardiovascular Surgery, Cosmetic Surgery, Neurosurgery, And Other Applications), By End-User (Ambulatory Surgery Centers, Specialty Clinics, And Hospitals), And By Region – Global And Regional Industry Overview, Market Intelligence, Comprehensive Analysis, Historical Data, And Forecasts 2022 – 2028 "into their research database. Tissue Sealants and Tissue Adhesive Market: Overview Sealants are materials used by surgeon to heal tissue that has been injured by a surgery or injury. Skin, internal organs, and blood vessels are among the tissues that have been damaged. Sealants are used in combination with mechanical procedures like sutures and staples to assist minimize blood loss and avoiding leaks. Tissue adhesives are liquid monomers that, when exposed to a moist surface (skin), begin an exothermic reaction, transforming into a polymer that establishes a strong tissue connection. Get a Free Sample Report with All Related Graphs & Charts (with COVID 19 Impact Analysis): Our Free Sample Report Includes: 2022 Updated Report Introduction, Overview, and In-depth industry analysis COVID-19 Pandemic Outbreak Impact Analysis Included 166 + Pages Research Report (Inclusion of Updated Research) Provide Chapter-wise guidance on Request 2022 Updated Regional Analysis with Graphical Representation of Size, Share & Trends Includes an Updated List of tables & figures Updated Report Includes Top Market Players with their Business Strategy, Sales Volume, and Revenue Analysis Zion Market Research methodology Industry Dynamics: Tissue Sealants and Tissue Adhesive Market: Growth Drivers Increase in number of orthopedic and cardiovascular procedures to foster the market. Over the forecast period, rising cardiovascular and orthopedic surgeries are expected to drive revenue growth in the global tissue sealants and tissue adhesive market. The ease of availability of novel tissue adhesives and tissue sealants among end users, combined with rising disposable money, is a major driver in the global increase in such procedures. Adhesives are essential in general surgery. Natural and manufactured polymeric materials can be used to create three-dimensional networks that adhere to target tissues chemically and physically, acting as adhesives, sealants, or hemostats. Because adhesives and sealants are such an important aspect of general surgery, demand for them will rise as the number of procedures performed increases. As a result, market growth is likely to be boosted . Tissue Sealants and Tissue Adhesive Market: Restraints Less market penetration for tissue sealants and adhesives in developing countries hinders the growth. The market's growth is also likely to be hampered by the dearth of acceptance of tissue glue and bio-adhesive sealants in developing markets. This is due to a lack of knowledge about the advantages, cost-effectiveness, therapeutic application, and reliability of tissue adhesive and tissue sealants against alternative procedures or products, as well as tissue healing therapies. Directly Purchase a Copy of the Report @ Global Tissue Sealants and Tissue Adhesive Market: Opportunities Technological advancement for product launches creates numerous opportunities for market growth. Companies have been working on the development of novel tissue glue and bio-adhesive sealants to reach a variety of consumers, including toddlers, and young and elderly patients, during the last few years. Tissue sealants are currently used to protect sensitive, fragile, skin from damage, and to prevent cross-contamination & infection transmission. For innovative product launches, major companies are investing heavily in R&D activities. All such factors are likely to generate numerous opportunities for the global tissue sealants and tissue adhesive market growth during the forecast period. Global Tissue Sealants and Tissue Adhesive Market: Challenges Limitations in the development of tissue adhesive to act as a major challenge for the market growth. Despite the fact that many tissue adhesives form strong connections with tissue, they are frequently not designed for specific tissue applications. Tissue adhesives, in particular, do not biodegrade at a rate consistent with tissue repair, cause an unwanted inflammatory response upon adhesion or disintegration, fail to cohere in high-load-bearing applications, or do not match the characteristics of the underlying tissue. In the early stages of development, rigorous differentiation of target applications and greater in-depth investigation of tissue-surface features and tissue-environmental parameters are necessary. Despite the fact that the surface of the tissue and the surrounding environment change amongst tissues, the most typical technique is to utilize one type of adhesive for all conceivable tissues. This "one-size-fits-all" approach frequently results in tissue adhesive misuse, leading to inferior performance and dampening enthusiasm for potentially promising new materials. This could also lead to an incorrect cost-effectiveness analysis for specified unmet clinical requirements in the early stages of development, culminating in an exaggeration of cost in later stages of development and obstructing clinical translation. A failure to understand the physiological effects of adhesive materials after implantation is another factor for the research-to-product mismatch. All such limitations may pose challenges to market growth . Global Tissue Sealants and Tissue Adhesive Market: Segmentation The global tissue sealants and tissue adhesive market is categorized based on product, application, end-user, and region. Based on the product, the market is divided into semi-synthetic & synthetic adhesives and biological or natural sealants. The application segment consists of neurosurgery, cosmetic surgery, cardiovascular surgery, gynecology surgery, orthopedic surgery, general surgery, and other applications. The end-user segment is bifurcated into ambulatory surgery centers, specialty clinics, and hospitals. Get More Insight before [email protected]: List of Key Players inTissue Sealants and Tissue Adhesive Market: Integra LifeSciences C.R Bard Smith & Nephew Exapharma Johnson & Johnson Baxter International Inc. Tissuemed Ltd. Chemence Medical Inc. Cohera Medical Inc. Luna Innovations Incorporated Key questions answered in this report: What are the growth rate forecast and market size for Tissue Sealants and Tissue Adhesive Market? What are the key driving factors propelling the Tissue Sealants and Tissue Adhesive Market forward? What are the most important companies in the Tissue Sealants and Tissue Adhesive Market Industry? What segments does the Tissue Sealants and Tissue Adhesive Market cover? How can I receive a free copy of the Tissue Sealants and Tissue Adhesive Market sample report and company profiles? Report Scope: Free Brochure: Recent Developments: In January 2020, Polyganics, a medical technology business that develops, manufactures, and sells bioresorbable medical devices, revealed that LIQOSEAL®, its effortless and unique dural sealant patch, has received CE certification and will be available in Europe immediately. In December 2019, Johnson & Johnson Medical Devices Companies announced that Ethicon has released VISTASEAL Fibrin Sealant (Human) to assist surgeons minimize bleeding during surgery. VISTASEAL Fibrin Sealant (Human) is made up of fibrinogen and thrombin, which are both clotting proteins present in human plasma. It creates a fast, adherent, and permanent clot after placed on the bleeding site and has been shown to maintain hemostasis (blood stoppage) in high-risk patients. Regional Dominance: North America is the leader in the global market. Among the regions, North America is estimated to lead the global tissue sealants and tissue adhesive market during the forecast period. Because of its large population and technical advancements, North America accounted for the largest share of tissue sealants and tissue adhesive. However, the market for tissue sealants and tissue adhesives is expected to expand significantly in Asia Pacific countries. Factors such as state-of-the-art medical research facilities and rising investments in healthcare infrastructure in this region, and also heightened understanding among both physicians & patients relating therapeutic approaches, enhanced life expectancy, and a rising population will push growing demands for tissue sealants and tissue adhesives in Asia Pacific region. Global Tissue Sealants and Tissue Adhesive Market is segmented as follows: Tissue Sealants and Tissue Adhesive Market:ByProduct Outlook(2022-2028) Natural or Biological Sealants and Adhesives Synthetic and Semi-Synthetic Adhesives Tissue Sealants and Tissue Adhesive Market: By ApplicationOutlook (2022-2028) General Surgery Orthopedic Surgery Gynecology Surgery Cardiovascular Surgery Cosmetic Surgery Neurosurgery Other Applications Tissue Sealants and Tissue Adhesive Market: By End-user Outlook (2022-2028) Hospitals Specialty Clinics Ambulatory Surgery Centers Tissue Sealants and Tissue Adhesive Market:By Region Outlook(2022-2028) North America The U.S. Canada Europe France The UK Spain Germany Italy Rest of Europe Asia Pacific China Japan India South Korea Southeast Asia Rest of Asia Pacific Latin America Brazil Mexico Rest of Latin America Middle East & Africa GCC South Africa Rest of Middle East & Africa Browse Other Related Research Reports from Zion Market Research Orthopedic Navigation Systems Market - Global Industry Analysis : The global Orthopedic Navigation Systems market accrued earnings worth approximately 2.1(USD Billion) in 2020 and is predicted to gain revenue of about 7.3 (USD Billion) by 2028, is set to record a CAGR of nearly 14.7% over the period from 2021 to 2028. Intravenous Infusion Pumps Market - Global Industry Analysis : The global Intravenous Infusion Pumps market accrued earnings worth approximately 4.7 (USD Billion) in 2020 and is predicted to gain revenue of about 8.9 (USD Billion) by 2028, is set to record a CAGR of nearly 8.1% over the period from 2021 to 2028. Disposable Hospital Gowns Market - Global Industry Analysis : The global Disposable Hospital Gowns market accrued earnings worth approximately 2.02 (USD Billion) in 2020 and is predicted to gain revenue of about 5.72 (USD Billion) by 2028, is set to record a CAGR of nearly 13.8% over the period from 2021 to 2028. Browse through Zion Market Research's coverage of the Global Medical Device Industry Follow Us on: LinkedIn | Twitter | Facebook About Us Zion Market Research is an obligated company. We create futuristic, cutting-edge, informative reports ranging from industry reports, and company reports to country report. We provide our clients not only with market statistics unveiled by avowed private publishers and public organizations but also with vogue and newest industry reports along with pre-eminent and niche company profiles. Our database of market research reports comprises a wide variety of reports from cardinal industries. Our database is been updated constantly in order to fulfill our clients with prompt and direct online access to our database. Keeping in mind the client's needs, we have included expert insights on global industries, products, and market trends in this database. Last but not the least, we make it our duty to ensure the success of clients connected to us—after all—if you do well, a little of the light shines on us . Contact Us: Zion Market Research 244 Fifth Avenue, Suite N202 New York, 10001, United States Tel: +49-322 210 92714 USA/Canada Toll Free No.1-855-465-4651 Email: [email protected] Website: Blog - Logo: SOURCE Zion Market Research

100 Deals associated with Fibrin Sealant (Baxter)

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hemorrhage	United States	Baxter Healthcare Corp.	07 Feb 2000

Clinical Result

Indication

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03276975 (CTgov)	Phase 2	Intracranial Hypotension \| Cerebrospinal Fluid Leak	15	TISSEEL	rfzfegoall(tdnawqyuet) = nznfqgxlrd xjrnxfgxas (zaletfptrg, evxwwpglnd - pbvoviftgg) View more	-	18 Jun 2021
NCT02891070 (CTgov)	Phase 3	Cerebrospinal Fluid Leak	224	Tisseel (Tisseel)	hhqbxoliny = rqfzhbrpsv ypudxxiygm (bkdfsuupja, xgdbezjjym - gruooackpz) View more	-	10 Sep 2019
				Sealant (DuraSeal)	hhqbxoliny = klfvxeazlx ypudxxiygm (bkdfsuupja, yuvwmxwsqf - uivroyctyi) View more
NCT01613664 (Pubmed \| Ann Surg)	Phase 3	-	586	Fibrin Sealant	shsjwslrix(pyhezsujcd) = zmiphkcdaw mbvtpbiybn (kszsceroyu ) View more	-	01 Nov 2018
				Fibrin Sealant (Control (without FS))	shsjwslrix(pyhezsujcd) = uvbatuwiww mbvtpbiybn (kszsceroyu ) View more
NCT01649505 (CTgov)	Not Applicable	Postoperative Complications \| Seroma \| Breast Cancer	2	breast reconstruction+TISSEEL+Beriplast (Arm I (Fibrin Sealant))	innggkvxwz(xipsmuazht) = bmfduwbcqn tgxxzettib (zfexnyzagq, bqkzdxxhmb - fpnunyqjwf) View more	-	15 Mar 2013
				breast reconstruction (Arm II (Standard Electrocoagulation))	innggkvxwz(xipsmuazht) = wgtsiwzukh tgxxzettib (zfexnyzagq, wwuaoqljrn - pluabwzqcb) View more
NCT01244425 (CTgov)	Phase 2	Hemorrhage	70	Fibrin Sealant (FS VH S/D 500 S-apr)	tbfxsjrcfy = jkwemvscdb oebmvcuxxc (xmzkeqgszn, vjzsubqpgn - aaigpbyuah) View more	-	12 Feb 2013
				Manual compression (Manual Compression - Control)	tbfxsjrcfy = ypfkfcflek oebmvcuxxc (xmzkeqgszn, jcssusjola - bayfoqsypo) View more
NCT00713596 (CTgov)	Not Applicable	Contusions	25	Taping after septorhinoplasty.+Saline	ysjbemtzea(roqnhyfyzi) = gdajzlowtw ukdhrfvtte (cvwnjejolg, ypfdkwpndw - abkcbgnaha) View more	-	24 Jul 2012
NCT00324272 (CTgov)	Phase 4	Melanoma \| Squamous Cell Carcinoma	74	Fibrin Sealant (Tisseel) used in the Experimental Arm. (Groin Dissection: Sealant Used.)	vmufpygjjv(eqlouztrli) = stxknqegjb zmluspmyei (jxkicyuauq, tgugeedhak - lwgctgekjm) View more	-	11 Aug 2011
				Fibrin Sealant (Tisseel) used in the Experimental Arm. (Groin Dissection: no Sealant Used.)	vmufpygjjv(eqlouztrli) = dpqufriovl zmluspmyei (jxkicyuauq, uxgxumjgot - oezrqlylkv) View more
Gynecologic Oncology Group study (Pubmed \| Gynecol Oncol)	Phase 3	Lymphedema	150	VH fibrin sealant (Sutured closure)	ymjssqxioh(kqqtcqyioj) = veupzorgqx bdpefxxuml (cvqhytptkc ) View more	Negative	01 Jul 2008
NCT00506311 (Pubmed \| World J Surg Oncol)	Not Applicable	Melanoma	30	Fibrin sealant	kfajamcsgp(tklesqzoga) = yxlmlnqmpa rgwbvfnhhx (pghimylzos )	Negative	18 Jun 2008
				Fibrin sealant (Control group)	kfajamcsgp(tklesqzoga) = nftcntmrqf rgwbvfnhhx (pghimylzos )

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