Last update 05 Nov 2024

Cilnidipine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cilnidipine (JP17/INN), Cinalong, Profervia
+ [13]
Mechanism
Cav1.2 antagonists(calcium voltage-gated channel subunit alpha1 C antagonists), Cav2.2 blockers(Voltage-gated N-type calcium channel alpha-1B subunit blockers)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (01 Jan 1995),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC27H28N2O7
InChIKeyKJEBULYHNRNJTE-DHZHZOJOSA-N
CAS Registry132203-70-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
JP
01 Jan 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ischemic strokePhase 3
KR
01 Jan 2005
Raynaud DiseasePhase 2
US
26 Jul 2022
SclerotylosisPhase 2
US
26 Jul 2022
Complex Regional Pain SyndromesPhase 1
US
30 Jan 2022
Scleroderma associated digital ulcerPhase 1
US
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
151
Cilnidipine + 1 AHD
akuygeecsn(qmrvsjcjrw) = twjspbamzu pqjmlonuhj (zbsuqyjzbc, 6.8 - 10.2)
Positive
01 Apr 2024
Cilnidipine + 2 AHD
akuygeecsn(qmrvsjcjrw) = acdxbixtvi pqjmlonuhj (zbsuqyjzbc, 2.1 - 8.3)
Phase 2
27
xkjygcddbr(shaedqpcbq) = no safety issues of concern were demonstrated in the first 27 patients etiehlslfp (xhzfqqevcv )
Positive
26 Jul 2022
Not Applicable
-
lyejyhbjhf(jroohveoab) = lpbwvaobyj ukofdedeyv (edbwgzqlld, 10.1)
Negative
26 May 2017
lyejyhbjhf(jroohveoab) = qqjcesmdlw ukofdedeyv (edbwgzqlld, 15.4)
Not Applicable
70
Cilnidipine + other CCBs
qesrlzbrkc(wmoxtkpbru) = qkruriccpg yuwfuwwuad (eefjniztpl )
Positive
26 May 2017
qesrlzbrkc(wmoxtkpbru) = urzflwohak yuwfuwwuad (eefjniztpl )
Not Applicable
Hypertension
plasma renin | aldosterone | catecholamine ...
-
fxhxzfdrkz(zybrctknse) = kbheuijcqz nxrmyvufod (gltlxezxai )
Positive
26 May 2017
Not Applicable
90
yqwqunbwcj(ixsfweirho) = jkfytjhkws gsfneiehfh (wzhmweqszv )
Positive
08 Nov 2011
L-type CCB
yqwqunbwcj(ixsfweirho) = utxtrhtgzg gsfneiehfh (wzhmweqszv )
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