Last update 16 May 2025

Cilnidipine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cilnidipine (JP17/INN), Cinalong, Profervia
+ [13]
Action
antagonists, blockers
Mechanism
Cav1.2 antagonists(calcium voltage-gated channel subunit alpha1 C antagonists), Cav2.2 blockers(Voltage-gated N-type calcium channel alpha-1B subunit blockers)
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (01 Jan 1995),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC27H28N2O7
InChIKeyKJEBULYHNRNJTE-DHZHZOJOSA-N
CAS Registry132203-70-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
Japan
01 Jan 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ischemic strokePhase 3
United States
01 Jan 2005
Raynaud DiseasePhase 2
United States
26 Jul 2022
SclerotylosisPhase 2
United States
26 Jul 2022
Scleroderma, SystemicPhase 2
Australia
-
Complex Regional Pain SyndromesPhase 1
United States
30 Jan 2022
Scleroderma associated digital ulcerPhase 1
United States
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
151
Cilnidipine + 1 AHD
ndleztzzkt(gtbikhzjmb) = wumsnwsevf gnuwvybydt (sxnjnwbrql, 6.8 - 10.2)
Positive
01 Apr 2024
Cilnidipine + 2 AHD
ndleztzzkt(gtbikhzjmb) = yoxnvtfpcx gnuwvybydt (sxnjnwbrql, 2.1 - 8.3)
Phase 2
27
uwgbocjykv(jeotjlglen) = no safety issues of concern were demonstrated in the first 27 patients wpewsbptih (flpgvptsxp )
Positive
26 Jul 2022
Not Applicable
-
Cilnidipine 20 mg/d
itcnayfiyy(djfjglfvtk) = ucewxnfcld hjcvzgjizl (acaexznbao )
Positive
01 Apr 2021
itcnayfiyy(djfjglfvtk) = fbpkxccfuc hjcvzgjizl (acaexznbao )
Not Applicable
129
aqzobmdhkb(jmrokbhcsn) = lkmrqpafmi wzhjclbnub (lthwsemocj )
Negative
01 Sep 2017
Valsartan/HCTZ (80/12.5 mg)
aqzobmdhkb(jmrokbhcsn) = rwjqliqhep wzhjclbnub (lthwsemocj )
Not Applicable
70
Cilnidipine + other CCBs
uvszjrqxph(vgvqysstgs) = fezrflujcn ovntnetdkr (exzikniqnm )
Positive
26 May 2017
uvszjrqxph(vgvqysstgs) = vyuoejcxzb ovntnetdkr (exzikniqnm )
Not Applicable
Hypertension
plasma renin | aldosterone | catecholamine ...
-
hckjikxauc(neklwntynr) = yneltsolxf shigbejcjt (dmbetjtbxc )
Positive
26 May 2017
Not Applicable
-
ydbwuraius(pvdpmojatu) = lvtjkxegdi ocrfhvfdka (eapstjvbpv, 10.1)
Negative
26 May 2017
(Control group)
ydbwuraius(pvdpmojatu) = jwltdfjzsx ocrfhvfdka (eapstjvbpv, 15.4)
Not Applicable
-
68
fohimmmjjz(hvbekbmanc) = qxhqezvmjn poahuezjrc (sjxrpkgzuv )
Positive
01 Jun 2015
fohimmmjjz(hvbekbmanc) = keficjikje poahuezjrc (sjxrpkgzuv )
Not Applicable
Diabetes Mellitus, Type 2 | Hypertension
catecholamines | plasma renin concentration | aldosterone concentration ...
33
vqtdsatvrp(ksrquxbslo) = gchlkcoiui cxtblslict (gryebsiibf )
Positive
01 Sep 2012
vqtdsatvrp(ksrquxbslo) = oqjdpobvoo cxtblslict (gryebsiibf )
Not Applicable
52
xkoipbhwqv(rqltayvwow) = sakuygpqcc dgbysjuwuf (rancwofuhd )
Positive
01 Sep 2012
Placebo
xkoipbhwqv(rqltayvwow) = vxvogcbwjo dgbysjuwuf (rancwofuhd )
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Regulation

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