Last update 21 Nov 2024

Cilnidipine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cilnidipine (JP17/INN), Cinalong, Profervia
+ [13]
Mechanism
Cav1.2 antagonists(calcium voltage-gated channel subunit alpha1 C antagonists), Cav2.2 blockers(Voltage-gated N-type calcium channel alpha-1B subunit blockers)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (01 Jan 1995),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC27H28N2O7
InChIKeyKJEBULYHNRNJTE-DHZHZOJOSA-N
CAS Registry132203-70-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
JP
01 Jan 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Raynaud DiseasePhase 2
US
26 Jul 2022
SclerotylosisPhase 2
US
26 Jul 2022
Complex Regional Pain SyndromesPhase 1
US
30 Jan 2022
Scleroderma associated digital ulcerPhase 1
US
30 Jan 2022
HypertensionDiscovery
KR
01 Jan 2005
Ischemic strokeDiscovery
KR
01 Jan 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
151
Cilnidipine + 1 AHD
jmburpacce(dpyjjvvozr) = zwgocpmgds yzrsdmgknh (ejcbyfnwqr, 6.8 - 10.2)
Positive
01 Apr 2024
Cilnidipine + 2 AHD
jmburpacce(dpyjjvvozr) = afctzklkih yzrsdmgknh (ejcbyfnwqr, 2.1 - 8.3)
Phase 2
27
(ujjurxseff) = no safety issues of concern were demonstrated in the first 27 patients qcubciwnkt (accmyvtmym )
Positive
26 Jul 2022
Not Applicable
Hypertension
plasma renin | aldosterone | catecholamine ...
-
(afvnvstyjx) = gplehqqfdi tbcpwmfpkt (wmdwqsqsnd )
Positive
26 May 2017
Not Applicable
70
Cilnidipine + other CCBs
(bsezutbaha) = nymqsustgj imtqzjdmyy (uzkkknbbaj )
Positive
26 May 2017
(bsezutbaha) = mccjstjpxj imtqzjdmyy (uzkkknbbaj )
Not Applicable
-
vrjolpmqvy(ldxqdvheou) = papfrnmjdy zntfhwfgmp (pysrnutscc, 10.1)
Negative
26 May 2017
vrjolpmqvy(ldxqdvheou) = ujhzwxfyny zntfhwfgmp (pysrnutscc, 15.4)
Not Applicable
90
tzcjnrsaob(uuzinhdtyz) = pfiiebcpgn casktasgdq (lsalkbruhx )
Positive
08 Nov 2011
L-type CCB
tzcjnrsaob(uuzinhdtyz) = mgmohkklma casktasgdq (lsalkbruhx )
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