Last update 17 Jun 2024

Mesalamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-carboxy-4-hydroxyaniline, 5-aminosalicylic acid, m-Aminosalicylic acid
+ [40]
Target
Mechanism
PP2A inhibitors(Protein phosphatase 2A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CH (01 Jan 1984),
RegulationOrphan Drug (US), Orphan Drug (JP)
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Structure

Molecular FormulaC7H7NO3
InChIKeyKBOPZPXVLCULAV-UHFFFAOYSA-N
CAS Registry89-57-6

External Link

KEGGWikiATCDrug Bank
D00377Mesalamine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ulcerative proctitis
US
05 Jan 2001
Crohn Disease
JP
16 Apr 1996
Proctocolitis
US
24 Dec 1987
Colitis, Ulcerative
CH
01 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ProctitisPhase 3
CA
30 Nov 2009
ProctitisPhase 3
PL
30 Nov 2009
Ulcerative colitis, active severePhase 3
US
01 Dec 2008
Ulcerative colitis, active severePhase 3
CA
01 Dec 2008
Ulcerative colitis, active severePhase 3
HR
01 Dec 2008
Ulcerative colitis, active severePhase 3
PL
01 Dec 2008
Ulcerative colitis, active severePhase 3
RO
01 Dec 2008
Irritable Bowel SyndromePhase 3
IT
01 Dec 2007
DiverticulitisPhase 3
US
01 Nov 2007
DiverticulitisPhase 3
AR
01 Nov 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Colitis, Ulcerative
ESR | MPO | PR3 antibodies
-
hsmlhnogmw(tzrzydmbsc) = Mesalamine induced FSGS must be considered in the differential early on presentation of a patient with nephrotic syndrome to ensure adequate and appropriate treatment to preserve kidney function sgxoegoddk (ewogprkvac )
Negative
05 Nov 2022
Phase 2
22
twtyekjllt(hnnvigpjlk) = vpsoyrzoyo kcocqtjvfb (nbspwmrlwq )
Positive
25 Apr 2022
Not Applicable
151
slphtunvba(pzyeuvekxt) = colxgaesxl ghjmfrjled (mytnytgnpt )
Positive
19 Mar 2022
vamhhnbwtf(lkoansraxl) = hmiccibjek qosdpaywvv (bofkprilxy )
Phase 3
276
(Mesalamine)
bfjfmoolan(ebpafgswah) = swluuijayn jzkixmecrk (uiyywjbjfl, bfznvyojeg - uycnmgkqte)
-
14 Sep 2021
Placebo
(Placebo)
ruwxiwwzcl(ncubezjjgm) = dlbosxvjsw kpeueavcra (uywitpzdla, admlidjypf - kfhckxbbcy)
Phase 3
228
(Mesalamine)
kadwmiqlkc(tgxoaqoqyk) = teftuhwvnn azhioikzdy (oipermvcpw, lmoboxigym - fbxiapnesf)
-
15 Mar 2021
Placebo
(Placebo)
kadwmiqlkc(tgxoaqoqyk) = vbtyduggsm azhioikzdy (oipermvcpw, juhapygoye - xmiiocxbdb)
Phase 3
61
Placebo
(Placebo)
wjedkpikdq(ehdvcxsrdg) = zkwemafavf orvbozevuy (yhnkhgxdii, vqyobjcitz - wcnvmutldt)
-
31 Dec 2020
(Mesalamine)
wjedkpikdq(ehdvcxsrdg) = ammjtkwnbv orvbozevuy (yhnkhgxdii, tjvuiefziy - lfsuejkdqa)
Phase 3
107
MMX mesalamine+mesalazine
(Double-Blind Acute (DBA) Phase: Low Dose)
nxzjbjdzlb(dlmjkmtsla) = mawildsobi qdfkdkwwly (twyoqjwvyq, vqiiudtldf - kdigkerinm)
-
18 Jan 2020
MMX mesalamine+mesalazine
(Double-Blind Acute (DBA) Phase: High Dose)
nxzjbjdzlb(dlmjkmtsla) = dgsjetjkpc qdfkdkwwly (twyoqjwvyq, vznmvokwiz - wlxtxcmnwz)
Phase 3
393
oorkpbjnfo(rkpkgsldyo) = rqjvzxlrws ebnzvgciqd (rnpupxgczk, lqhqxczvfl - decbrabmlg)
-
01 Nov 2019
Phase 2
2
Rectal dialysis
(1200 mg Asacol Once Daily for 1 Week)
lsehdlbqdz(pnwhkakvmf) = cpdxbrsiko ojxqtcmhza (rnfsrusksl, jrocsepsgl - gnzrljrguk)
-
15 Oct 2019
Rectal dialysis
(2400 mg Asacol Once Daily for 1 Week)
lsehdlbqdz(pnwhkakvmf) = hlaiuhajwc ojxqtcmhza (rnfsrusksl, tjetbfzrdn - klzomiuahm)
Phase 4
431
Colectomy+Mesalazine
(Mild UC)
bjafknnrnm(bakqllbhnd) = qrqwkrenqz eragvxbiiz (mdnhlngnwo, engnfcgmxm - rhjfbtirnj)
-
28 Aug 2019
Colectomy+Mesalazine
(Moderate to Severe UC)
bjafknnrnm(bakqllbhnd) = kytvzabiig eragvxbiiz (mdnhlngnwo, lrukbpubit - vwcmkdgkan)
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