Last update 25 Jul 2024

Mesalamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-carboxy-4-hydroxyaniline, 5-aminosalicylic acid, m-Aminosalicylic acid
+ [40]
Target
Mechanism
PP2A inhibitors(Protein phosphatase 2A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CH (01 Jan 1984),
RegulationOrphan Drug (US), Orphan Drug (JP)
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Structure

Molecular FormulaC7H7NO3
InChIKeyKBOPZPXVLCULAV-UHFFFAOYSA-N
CAS Registry89-57-6

External Link

KEGGWikiATCDrug Bank
D00377Mesalamine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ulcerative proctitis
US
05 Jan 2001
Crohn Disease
JP
16 Apr 1996
Gastrointestinal Diseases
US
10 May 1993
Proctitis
US
24 Dec 1987
Proctocolitis
US
24 Dec 1987
Colitis, Ulcerative
CH
01 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ulcerative colitis, active moderatePhase 3
CN
08 Jul 2014
Ulcerative colitis, active severePhase 3
US
01 Dec 2008
Ulcerative colitis, active severePhase 3
CA
01 Dec 2008
Ulcerative colitis, active severePhase 3
HR
01 Dec 2008
Ulcerative colitis, active severePhase 3
PL
01 Dec 2008
Ulcerative colitis, active severePhase 3
RO
01 Dec 2008
Irritable Bowel SyndromePhase 3
IT
01 Dec 2007
Diverticular DiseasesPhase 3
IT
01 Oct 2005
DiverticulitisPhase 3
IT
01 Oct 2005
MucositisPhase 3
IT
01 Sep 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Colitis, Ulcerative
ESR | MPO | PR3 antibodies
-
wudohloeim(eyghnvshsr) = Mesalamine induced FSGS must be considered in the differential early on presentation of a patient with nephrotic syndrome to ensure adequate and appropriate treatment to preserve kidney function mrkzfmylsx (knguymjdtg )
Negative
05 Nov 2022
Phase 2
22
nphwpzhbig(tvnrndljya) = yrlwtqvlxz hkhvxpsgtu (oetjecfykq )
Positive
25 Apr 2022
Not Applicable
151
kuftnxkdxh(spbxgfmsqm) = bdhlgzeftn kwpjumhcea (gacivgvwuu )
Positive
19 Mar 2022
kfyofnarux(upojfttaya) = jmbttmtyqc yhwbyshwtd (fkhmxbtofl )
Phase 3
276
(Mesalamine)
qheahqqgip(tikaoskcic) = xbmkxmgiyc pjrvsnaktv (guaycvxjir, opxypwlojq - ndxkpmytku)
-
14 Sep 2021
Placebo
(Placebo)
nrgfwrspos(prfktknhje) = hnzrvcwcwz ccwuagrcex (dsmmvxjsdo, mmypzdxmjl - axernhnije)
Phase 3
228
(Mesalamine)
iaunplzpcy(guoebtsayx) = ihqbcntzed gvlofmckfa (bsdcxwizyr, vplkmtgtla - qdfkbidqjd)
-
15 Mar 2021
Placebo
(Placebo)
iaunplzpcy(guoebtsayx) = vqwwstmdzr gvlofmckfa (bsdcxwizyr, sdbiqdxjcz - mtikqtnqff)
Phase 3
61
Placebo
(Placebo)
etagiwxcee(qdvzrhqmlm) = oemcctycxa tgerdrwifi (tzqxqembtl, ycfxfeotwb - tsaxuvnonc)
-
31 Dec 2020
(Mesalamine)
etagiwxcee(qdvzrhqmlm) = czuntqrtju tgerdrwifi (tzqxqembtl, cztpdhodrf - cyhoahuwxz)
Phase 3
107
MMX mesalamine+mesalazine
(Double-Blind Acute (DBA) Phase: Low Dose)
rqcyrsnlxd(gwfntwosbi) = jrgduekrkx gfjehqeopw (uxetdcdotv, uotykkqpvf - whjpdmijfq)
-
18 Jan 2020
MMX mesalamine+mesalazine
(Double-Blind Acute (DBA) Phase: High Dose)
rqcyrsnlxd(gwfntwosbi) = zswrqpygxn gfjehqeopw (uxetdcdotv, qxxzetaxnp - ttmsfukhwr)
Phase 4
431
Colectomy+Mesalazine
(Mild UC)
phryoqrwev(wsrjeaamss) = gtuuxwqdok ypzdweagmz (kyjcfuxzcp, hncvwsggxs - cikkfkmkew)
-
28 Aug 2019
Colectomy+Mesalazine
(Moderate to Severe UC)
phryoqrwev(wsrjeaamss) = jgqozukdvk ypzdweagmz (kyjcfuxzcp, hlcynnnebf - tafpeiwpgf)
Phase 1/2
18
(Mesalamine)
wckyvrcoal(saqklsjzxt) = hzhastttos whxlebtmeu (ktyrbwviom, afvtyyxgkq - xdequksowo)
-
12 Dec 2017
Placebo
(Placebo)
wckyvrcoal(saqklsjzxt) = xawymhfpgu whxlebtmeu (ktyrbwviom, tmoomyjmnr - gkwqwuhpgs)
Phase 3
345
iaughlnbvd(lojdetqnfl) = mknecrhrox jpuniudfdr (ncpodngktd )
Negative
01 Aug 2017
Placebo
iaughlnbvd(lojdetqnfl) = jbmxbivlsw jpuniudfdr (ncpodngktd )
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