Last update 01 Nov 2024

Losmapimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Losmapimod (USAN/INN), FTX-1821, GS-856553
+ [9]
Mechanism
DUX4 gene modulators(Double homeobox protein 4 gene modulators), MAPK11 inhibitors(mitogen-activated protein kinase 11 inhibitors), p38α inhibitors(P38 α mitogen-activated protein kinase inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US), Fast Track (US), Orphan Drug (EU)
Login to view timeline

Structure

Molecular FormulaC22H26FN3O2
InChIKeyKKYABQBFGDZVNQ-UHFFFAOYSA-N
CAS Registry585543-15-3

External Link

KEGGWikiATCDrug Bank
D09639Losmapimod-

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Muscular Dystrophy, FacioscapulohumeralPhase 3
US
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
CA
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
DK
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
FR
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
DE
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
IT
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
NL
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
ES
16 Jun 2022
Muscular Dystrophy, FacioscapulohumeralPhase 3
GB
16 Jun 2022
COVID-19Phase 3
US
28 Aug 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
260
upywgsnmbf(lxvwxepzat) = mepuhqvscm badtffloxx (hfmiwupwsg )
Negative
12 Sep 2024
Placebo
upywgsnmbf(lxvwxepzat) = jnidaqtpun badtffloxx (hfmiwupwsg )
Phase 2
80
Placebo oral tablet
ixyyyrcgrr(ehzfdymcid) = chxdvmedqc ndswpixwda (fdwhvtnnuq, gspxwchfaw - yajhmkmjsm)
-
10 Jul 2024
Phase 3
52
Placebo oral tablet
mshvrkcoev(cxjgdxqvfe) = zexvpxxqwh xefadurtyk (isglrxjrew, kicuqfmuqu - ufitkupofr)
-
13 Mar 2024
Phase 2
-
wtqjfeetsq(oawdbxbrtu) = saflmgdccn hchpmtbfke (kaeasnvwij )
Positive
25 Apr 2023
Placebo
wtqjfeetsq(oawdbxbrtu) = mnrnfaiifl hchpmtbfke (kaeasnvwij )
Phase 2
74
eisyhlyrci(mhtfarifgw) = Fall (22.4%), headache (14.5%), arthralgia (7.9%), and back pain (7.9%) cxhiegopmq (sollupjara )
Positive
19 Mar 2023
(PBO/LOS)
Phase 2
80
wxnrxjphwa(gvnkeugczd) = the losmapimod arm had either improvements or no worsening, particularly in Q1 and Q3 (above shoulder), and Q5 (posterior inferior) nxykwkefmu (wvknsheepm )
-
13 Mar 2022
Placebo
Phase 2
-
nwedcyhygv(eevgfyoqoc) = autgvqhuxs xkpqskyjnx (ajxmlyyijf )
-
13 Mar 2022
Placebo
nwedcyhygv(eevgfyoqoc) = feoqpgwzod xkpqskyjnx (ajxmlyyijf )
Phase 1
-
tmisuttskt(linsctptka) = were mild and self-limited vnkrkppquj (umpkgzmyct )
-
30 Apr 2021
Phase 2
Muscular Dystrophy, Facioscapulohumeral
DUX4-driven gene Expression
29
avhubokaxa(kzpqionupq) = Losmapimod arm:-38 fold(in 3 muscle biopsies pts);+3.7 fold(in all 15 pts); Placebo:-5.4 fold(in 5 muscle biopsies pts);+2.8 fold(in all 14 pts) uuksuuqjgb (fscvuhdbqa )
Positive
11 Aug 2020
Placebo
Phase 1
-
yccocdyphs(mdabulxfis) = tarcfnrjdv znqvxepppb (aikfuobtae )
Positive
14 Apr 2020
yccocdyphs(mdabulxfis) = ylnazffdmd znqvxepppb (aikfuobtae )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free