This is a double-blind, pilot study with 20 subjects to determine the tolerability and efficacy of topical AFX 5931 in the treatment of mild to moderate hand dermatitis. Subjects are screened up to 30 days before the baseline visit. Subjects who meet the eligibility criteria may qualify for the study. Subjects will be randomized in a 3:1 ratio to receive either the active or vehicle medication. 15 subjects will receive the active, therapeutic product and 5 subjects will receive the inactive, vehicle product.

Start Date18 Sep 2018

Sponsor / Collaborator

Center For Clinical & Cosmetic Research

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100 Clinical Results associated with AFX-5931

100 Translational Medicine associated with AFX-5931

100 Patents (Medical) associated with AFX-5931

Literatures (Medical) associated with AFX-5931

Journal of cutaneous medicine and surgery

A Review of Existing and New Treatments for the Management of Hand Eczema.

Review

Author: Ho, Jessica S S ; Molin, Sonja

Hand eczema is a chronic condition that affects an estimated 14.5% of the general population. It has severe quality of life ramifications in those that struggle with it, including days missed from work or school, productivity loss and impaired work functioning. For years, the standard of care included topical moisturizing creams, topical steroids and more recently systemic agents. As new therapeutic targets emerge and recent advances are being developed, it is now more possible than ever that hand eczema can be managed via the underlying mechanisms. A review of the literature was conducted to identify current treatment options for hand eczema and chronic hand eczema. The terms 'hand eczema', 'hand dermatitis' were used to search PubMed, CENTRAL and Embase. To identify new therapies still undergoing investigation, we used the terms 'hand eczema', 'hand dermatitis', 'atopic dermatitis', and 'vesicular eczema of hands and/or feet' to search Clinicaltrials.gov for all studies until December 2022. There were 56 ongoing clinical trials identified for pharmacological treatments for hand eczema on Clinicaltrials.gov from 2000 - 2022, with 16 that are new or ongoing. These included studies for dupilumab, ruxolitinib, delgocitinib (LEO124249), gusacitinib (ASN002), AFX 5931, and roflumilast (ARQ-252). Two major classes of drugs emerging for the treatment of hand eczema include IL-4/IL-13 inhibitors and JAK inhibitors. With the increase in efficacy seen with these new drugs, we are also noting improved adverse effect profiles, making them attractive options to add to a clinician's management toolbox for patients with hand eczema.

100 Deals associated with AFX-5931

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetic Retinopathy	Phase 3	US	-	23 Mar 2021
Eczema	Phase 3	US	-	-
Eczema	Phase 2	-	Afecta Pharmaceuticals, Inc.	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03703895 (AFX5931, CTgov)	Phase 4	Hand Dermatoses	20	Topical AFX5931 (Active Comparator)	hvygrcmqen(bumojbdhbe) = webqkpmudr krhtonkwxl (yzwepaodww, omjiwpfsul - sithvyztlm) View more	-	23 Nov 2022
				Topical Placebo (Placebo Comparator)	hvygrcmqen(bumojbdhbe) = xowvgumelb krhtonkwxl (yzwepaodww, jyendooptp - melsqvlnmk) View more

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