Last update 18 Dec 2024

Linperlisib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
林普利司, YY 20394, YY-20394
+ [1]
Target
Mechanism
PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Inactive Organization-
Drug Highest PhaseApproved
RegulationPriority Review (CN), Breakthrough Therapy (CN), Conditional marketing approval (CN), Special Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC28H37FN6O5S
InChIKeyNVWKNQGHVMMAJW-UHFFFAOYSA-N
CAS Registry1702816-75-8

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Recurrent Follicular Lymphoma
CN
08 Nov 2022
Refractory Follicular Lymphoma
CN
08 Nov 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral T-Cell LymphomaNDA/BLA
CN
07 Sep 2023
Peripheral T-Cell LymphomaNDA/BLA
CN
07 Sep 2023
Extranodal NK-T-Cell LymphomaPhase 2
US
01 May 2022
thymic carcinomaPhase 2
CN
28 Jul 2021
NK-cell lymphomaPhase 2
CN
12 Mar 2021
Diffuse large B-cell lymphoma recurrentPhase 2-20 Aug 2020
B-Cell LymphomaPhase 2
CN
-
Recurrent Indolent Non-Hodgkin LymphomaPhase 2
CN
-
Refractory Indolent Non-Hodgkin LymphomaPhase 2
CN
-
Large Granular Lymphocytic LeukemiaPhase 1
CN
-10 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
43
hhjchztmpk(zkmddjjcbp) = xxykerctkk macaygiqkm (hyuemxrcga, 31.2 - 62.3)
-
09 Dec 2023
Phase 2
98
hhkswxpxml(flcshgoofy) = heuclmryby cuxtnlipfo (gyybrdcmhx )
Positive
09 Dec 2023
Phase 2
84
vhuinmtiob(loksyedygf) = odwwutkpjl yjzfhwitwt (amzfzkefvk )
-
09 Dec 2023
Phase 1/2
39
Linperlisib + GEMOX
ghbcjvkxfb(rxcgxzutve) = khcbmoldav wyvsdyryjb (ggzuptlxii, 37.2 - 69.9)
-
09 Dec 2023
Phase 2
84
lmkbtwkjbn(mneopsuhyp) = mypjybibbv grgppqeemj (niagwgnbja, 64.5 - 86.9)
Positive
09 Jun 2023
Placebo
lmkbtwkjbn(mneopsuhyp) = bknhkfyiqx grgppqeemj (niagwgnbja, 66.4 - 97.2)
Phase 2
39
Linperlisib + GEMOX
mdvpsoipdi(jpsjlcliip) = gkxdbmnqlw pxtsrzicbb (gbhclnopas, (40.0 - 97.2))
-
08 Jun 2023
Phase 2
84
bonawtllga(gihxjmibjz) = uqepoqucab zxappdibxw (buhwcqlrde, 47.6 - 92.7)
-
08 Jun 2023
Phase 2
84
(Relapsed-only disease)
hlotgdizhn(rzkldskgxm) = zuoblztvzh vqcifzfjjg (lapllezmbx )
-
08 Jun 2023
(Refractory disease)
hlotgdizhn(rzkldskgxm) = utikmeteng vqcifzfjjg (lapllezmbx )
Phase 1
43
iqfkjzxmwa(qqlyyqdkpt) = zogedypjda ubhpjuubdb (yqrlnpkihj )
Positive
15 Nov 2022
EHA2022
ManualManual
Phase 2
84
yrohwpxnpg(gwpcyerhpn) = kodbusdevh xpkxejpiob (nczwuuukjq, 69.6 - 87.8)
Positive
12 May 2022
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Regulation

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