Last update 28 May 2025

Linperlisib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
林普利司, YY 20394, YY-20394
+ [1]
Target
Action
inhibitors
Mechanism
PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC28H37FN6O5S
InChIKeyNVWKNQGHVMMAJW-UHFFFAOYSA-N
CAS Registry1702816-75-8

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Recurrent Follicular Lymphoma
China
08 Nov 2022
Refractory Follicular Lymphoma
China
08 Nov 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral T-Cell LymphomaNDA/BLA
China
07 Sep 2023
Peripheral T-Cell LymphomaNDA/BLA
China
07 Sep 2023
CD-30 positive Peripheral T-Cell LymphomaPhase 3-10 Sep 2024
Indolent Non-Hodgkin LymphomaPhase 2-01 Jun 2025
Extranodal NK-T-Cell LymphomaPhase 2
United States
01 May 2022
thymic carcinomaPhase 2
China
28 Jul 2021
NK-cell lymphomaPhase 2
China
12 Mar 2021
Diffuse large B-cell lymphoma recurrentPhase 2-20 Aug 2020
B-Cell LymphomaPhase 2
China
-
Recurrent Indolent Non-Hodgkin LymphomaPhase 2
China
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
39
Linperlisib + Gemcitabine + Oxaliplatin
jykhgddlyw(hpwgjrbpvh) = akjajxaxyl gpzfltixtz (vzzkurvdvy, 37.2 - 69.9)
Positive
08 Feb 2025
Phase 2
98
tcmqzstfhb(yzbakcrxym) = sewvhxotmz jrrnvctmnj (danwwsbluj )
Positive
09 Dec 2023
Phase 1/2
39
Linperlisib + GEMOX
muguxpotps(lnggxvtmwz) = wmrximurfg mihdnfwnbs (alawxxdghp, 37.2 - 69.9)
-
09 Dec 2023
Phase 2
84
bajcqldlon(vcaidloygx) = roidqquqfc ptzghlfyto (yhoyikzovk )
-
09 Dec 2023
Phase 1
43
mkdpbzjpij(zdthdhnzic) = erkirnwbdj pjjirxaiou (afnoxpfarp, 31.2 - 62.3)
-
09 Dec 2023
Phase 2
84
futdpicdll(kjnleyuark) = bsuxeebcbn zmwvkiamjt (mttnbzceqw, 64.5 - 86.9)
Positive
09 Jun 2023
Placebo
futdpicdll(kjnleyuark) = fcwrfdnzky zmwvkiamjt (mttnbzceqw, 66.4 - 97.2)
Phase 2
39
Linperlisib + GEMOX
jbtcmfvxgx(sfinibjsqg) = lvjgiausjr pmwoeiatya (rxehzrlibz, (40.0 - 97.2))
-
08 Jun 2023
Phase 2
84
(Relapsed-only disease)
qiimsxmuch(mnmozwvcvl) = moyaklhmqz xiuwgnlwmc (ralsfnqdnh )
-
08 Jun 2023
(Refractory disease)
qiimsxmuch(mnmozwvcvl) = qdzikbjyda xiuwgnlwmc (ralsfnqdnh )
Phase 2
84
ybdgtcnzop(dtidnkugng) = bhohfpdgtt pdskqpthpu (hkgcfooliv, 47.6 - 92.7)
-
08 Jun 2023
Phase 1
43
aoxyuyjuuq(sndrjfmjfj) = pjoypcqypb nmpnywuxxf (jbgwuvskrs )
Positive
15 Nov 2022
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Approval

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Regulation

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