Last update 19 Sep 2024

Solriamfetol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R)-2-amino-3-phenylpropyl carbamate, Solriamfetol hydrochloride (USAN), solriamfetol
+ [13]
Mechanism
DAT antagonists(Dopamine transporter antagonists), NET inhibitors(Norepinephrine transporter inhibitors), TAAR1 inhibitors(Trace amine-associated receptor 1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC10H15ClN2O2
InChIKeyKAOVAAHCFNYXNJ-SBSPUUFOSA-N
CAS Registry178429-65-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Excessive Daytime Sleepiness
LI
16 Jan 2020
Excessive Daytime Sleepiness
EU
16 Jan 2020
Excessive Daytime Sleepiness
NO
16 Jan 2020
Excessive Daytime Sleepiness
IS
16 Jan 2020
Narcolepsy
US
20 Mar 2019
Sleep Apnea, Obstructive
US
20 Mar 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Idiopathic HypersomniaPreclinical
FR
01 May 2015
Idiopathic HypersomniaPreclinical
CA
01 May 2015
Idiopathic HypersomniaPreclinical
DE
01 May 2015
Idiopathic HypersomniaPreclinical
NL
01 May 2015
NarcolepsyPreclinical
DE
01 May 2015
NarcolepsyPreclinical
FI
01 May 2015
NarcolepsyPreclinical
US
01 May 2015
NarcolepsyPreclinical
FR
01 May 2015
NarcolepsyPreclinical
NL
01 May 2015
NarcolepsyPreclinical
CA
01 May 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
66
(Solriamfetol)
pgkxixrcft(tqyqcbbjux) = lcjwzvytkd mgkraklwyf (pcnurrvzsr, dtawweqefo - hityyitljh)
-
04 Mar 2024
Placebo
(Placebo)
pgkxixrcft(tqyqcbbjux) = fbkulpbycc mgkraklwyf (pcnurrvzsr, dyuynhsbov - pwsvlgkakd)
Not Applicable
-
(jgfgpyegta) = 3.4% xcboylkqco (krwhcscpxu )
-
25 Oct 2023
Placebo
Not Applicable
-
(wegpvyroqp) = Common adverse effects were headache budxutchew (sltprlubxj )
-
24 Oct 2023
Not Applicable
-
(zndtmvnyie) = No weight-related treatment-emergent adverse events were serious syhqlebrnw (vabnoirxtb )
-
14 Aug 2022
Not Applicable
-
(cloulueqld) = ytjapccdlh lggktnfaol (jboewzyhww )
-
20 Jul 2021
(myillprjox) = qoueodzipy fmijtondbu (solvgfycmc )
Phase 2
66
(lpgmtsitjs) = 5.4% ejvsefwpjb (sddzjhehvp )
-
30 Jun 2021
Phase 3
476
htqyrunlhm(thefdqmuzc) = yqlkneonpp xdmaliuhde (jnwdetmkkc, 0.6 - 9.0)
-
22 Feb 2021
htqyrunlhm(thefdqmuzc) = iwleljsxhd xdmaliuhde (jnwdetmkkc, 4.3 - 12.5)
Phase 2
24
Placebo
(Placebo)
uhtnhwilzt(fwezwvesrj) = yklisabafg elqhmswmgw (ioqyoeyzjy, jhtxshlgvb - iiydwbefyl)
-
13 Jan 2021
(JZP-110)
uhtnhwilzt(fwezwvesrj) = gbamejuuqz elqhmswmgw (ioqyoeyzjy, mqgzdkyosh - uhjszaoxwn)
Phase 3
-
nytgpqzaps(tyndsrilnc) = efeyihjtxz hsldwohnhg (dytdcnxwpq )
-
23 Nov 2020
nytgpqzaps(tyndsrilnc) = gjylsmmvom hsldwohnhg (dytdcnxwpq )
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Regulation

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