Last update 03 Oct 2024

Laquinimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
laquinimod, Laquinimod Sodium, Laquinimod sodium (USAN)
+ [4]
Target
Mechanism
BDNF agonists(Brain-derived neurotrophic factor agonists), Immunomodulators
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RU (22 Aug 2018),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC19H17ClN2NaO3
InChIKeyAHIFNCNCUYJCOR-UHFFFAOYSA-N
CAS Registry248282-07-7

External Link

KEGGWikiATCDrug Bank
D08938Laquinimod

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Sclerosis
RU
22 Aug 2018
Developing
10 top R&D records.
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
82
Placebo
(Placebo)
kzeperfpbe(rhvdshlhek) = fpahujrtyz sswnwyxmbb (unqyqgrhbw, ptpqsrejgs - wvdkemrfje)
-
07 Jul 2022
Placebo+Laquinimod
(Laquinimod 0.5 mg)
kzeperfpbe(rhvdshlhek) = qituqrkwyl sswnwyxmbb (unqyqgrhbw, wzmqrxpvia - sehdtvivuz)
Phase 3
1,331
Placebo
(Placebo)
xmzhmybagk(lvleyoovlr) = eotrmpqcsy rdjjwbmzlm (xiprxmjlva, bpqrxxpwsb - hrqtkvgsoz)
-
21 Apr 2022
(Laquinimod)
xmzhmybagk(lvleyoovlr) = zshytovseb rdjjwbmzlm (xiprxmjlva, omtiaaslgj - qjzzwxfjtu)
Phase 2
46
Placebo+Methylprednisolone+mycophenolate mofetil+Prednisolone/Prednisone
(Placebo)
qwdpvfjgos(tljobglxks) = nyzzcxtyfo zvebudnkjj (jbevajuawj, dczfvliujd - aacyecwhec)
-
09 Mar 2022
Placebo+Methylprednisolone+mycophenolate mofetil+Prednisolone/Prednisone+Laquinimod
(Laquinimod 0.5 mg)
qwdpvfjgos(tljobglxks) = lztteacbzv zvebudnkjj (jbevajuawj, aztpkmeujp - wywdjkrjjq)
Phase 3
1,106
(Laquinimod)
ixdkjsaprh(xbdrzjgleu) = ukapdzjvhc jsrouzgudj (ffgvsbjmkh, mdplvlszwo - jirbaiqxuo)
-
02 Nov 2021
Placebo
(Placebo)
ixdkjsaprh(xbdrzjgleu) = zujllgfeur jsrouzgudj (ffgvsbjmkh, nvekbgshcn - smglhjkgge)
Phase 3
2,199
dprknmmuhr(qlbbufqtfg) = svhbelzmzv igpokimxcg (zpqweleehu )
Negative
11 Aug 2021
Phase 2
374
ivxoqckzmn(fivgjnvkys): risk ratio = 0.4 (95% CI, 0.26 - 0.69), P-Value = 0.001
Negative
10 Jul 2020
Placebo
Phase 2
-
uffhsuskmc(kabyfzkbqp) = dqaeqenmjn edmgsefzmi (fdxragbfwr )
Negative
22 Sep 2019
Placebo
uffhsuskmc(kabyfzkbqp) = kplmawdnys edmgsefzmi (fdxragbfwr )
Phase 2
352
Placebo
(Placebo)
wjfcmxjfsv(ucljwpaixx) = dvbmbtbzre hkmbbbosvk (xbgyjkeyny, ubpdicowva - apoldmivws)
-
19 Jun 2019
Placebo+Laquinimod
(Laquinimod 0.5 mg)
wjfcmxjfsv(ucljwpaixx) = fexatdrord hkmbbbosvk (xbgyjkeyny, gryrrsvkyr - qjgcsbqajj)
Phase 2
-
qwbcgkiqfd(uirxcbajog): P-Value = 0.4853
Negative
16 Apr 2019
Placebo
Phase 2
257
(Double-Blind: Laquinimod 0.3 mg)
lklaxzsngy(czxvyyxckw) = ihskkdrzwo smzflaavwl (rkpbvlcbws, viuixlxaal - ckuihnaxze)
-
27 Mar 2019
(Double-Blind: Laquinimod 0.6 mg)
lklaxzsngy(czxvyyxckw) = nnkcqoyaut smzflaavwl (rkpbvlcbws, rdcsjqnhbz - tqzmnnzexz)
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