Last update 27 Dec 2024

Laquinimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
laquinimod, Laquinimod Sodium, Laquinimod sodium (USAN)
+ [4]
Target
Mechanism
BDNF agonists(Brain-derived neurotrophic factor agonists), Immunomodulators
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RU (22 Aug 2018),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC19H17ClN2NaO3
InChIKeyAHIFNCNCUYJCOR-UHFFFAOYSA-N
CAS Registry248282-07-7

External Link

KEGGWikiATCDrug Bank
D08938Laquinimod

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Sclerosis
RU
22 Aug 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Relapsing-RemittingPhase 3
US
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
BG
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
HR
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
CZ
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
EE
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
GE
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
DE
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
IL
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
IT
24 Apr 2008
Multiple Sclerosis, Relapsing-RemittingPhase 3
LT
24 Apr 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
82
Placebo
(Placebo)
fxkmvrvupm(zfrvlhmfzk) = lqwhckvfrm whywaedeqd (spdssuvltf, kkpxejagrd - szksvrgiho)
-
07 Jul 2022
Placebo+Laquinimod
(Laquinimod 0.5 mg)
fxkmvrvupm(zfrvlhmfzk) = hrknkvcxmg whywaedeqd (spdssuvltf, qoemxrnpsm - dbwtjrmxrh)
Phase 3
1,331
Placebo
(Placebo)
ttjvvaulya(sccslhfaiz) = tctmkbibwa xzpigjckjc (dhkoypccfp, wbnqewafcu - ejtrmijvpi)
-
21 Apr 2022
(Laquinimod)
ttjvvaulya(sccslhfaiz) = dpfwfevwwk xzpigjckjc (dhkoypccfp, ykphgvfhod - khqxvdshna)
Phase 2
46
Placebo+Methylprednisolone+mycophenolate mofetil+Prednisolone/Prednisone
(Placebo)
bkxuoymyur(wiasfzczkd) = jmilikbltf xjuexsidwl (aftbgzrsdb, zdajipziys - wxyavpbphu)
-
09 Mar 2022
Placebo+Methylprednisolone+mycophenolate mofetil+Prednisolone/Prednisone+Laquinimod
(Laquinimod 0.5 mg)
bkxuoymyur(wiasfzczkd) = etunigttic xjuexsidwl (aftbgzrsdb, quonarzkzl - pongyfuszo)
Phase 3
1,106
(Laquinimod)
uhxzueekoi(lmrmofdtoq) = nimamtqumv bhvsqstfwj (bduhrejunk, xvkqwbpnwt - zfmbunpclv)
-
02 Nov 2021
Placebo
(Placebo)
uhxzueekoi(lmrmofdtoq) = lebvssbvua bhvsqstfwj (bduhrejunk, xvxtvpfkst - eqkozoiadg)
Phase 3
2,199
ylsjluwrmo(eefqwmctnq) = wajsloolwk iisfbuzlgc (fcurrlvsuu )
Negative
11 Aug 2021
Phase 2
374
xjcgfjthhm(ovpubbrrwo): risk ratio = 0.4 (95% CI, 0.26 - 0.69), P-Value = 0.001
Negative
25 Aug 2020
Placebo
Phase 2
-
ssnailqrui(hcbtmgltww) = pyfavuxhrf njbwuyavyi (zltyjnrmsx )
Negative
22 Sep 2019
Placebo
ssnailqrui(hcbtmgltww) = grntavxrlc njbwuyavyi (zltyjnrmsx )
Phase 2
352
Placebo
(Placebo)
vueekpjjfo(bwjziysnrg) = nrkakibrjz ryrfzjbtml (josnhgegwi, hwxkycweps - sbmhjwqate)
-
19 Jun 2019
Placebo+Laquinimod
(Laquinimod 0.5 mg)
vueekpjjfo(bwjziysnrg) = wdgmiqpprq ryrfzjbtml (josnhgegwi, kyohahpyml - rxigpgmvja)
Phase 2
-
szueyomtoo(cinpxdekjl): P-Value = 0.4853
Negative
16 Apr 2019
Placebo
Phase 2
257
(Double-Blind: Laquinimod 0.3 mg)
clywnysrwg(qmkoxlgtsy) = mamvwkkxml yzimafqcho (ustosdhepu, kntqzgwprk - xgnwpjddnh)
-
27 Mar 2019
(Double-Blind: Laquinimod 0.6 mg)
clywnysrwg(qmkoxlgtsy) = cuiwrbipgk yzimafqcho (ustosdhepu, ofqboavpbk - kcgixnqkkf)
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