Last update 01 Nov 2024

Tarextumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-Notch 2/3, Anti-Notch 2/3 monoclonal antibody, TRXT
+ [2]
Mechanism
NOTCH2 antagonists(Neurogenic locus notch homolog protein 2 antagonists), NOTCH3 antagonists(Neurogenic locus notch homolog protein 3 antagonists)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D11775Tarextumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerPhase 2--
Small Cell Lung CancerPhase 2--
Extensive stage Small Cell Lung CancerPreclinical
US
07 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
217
(P1B: OMP-59R5 2.5 mg/kg + Gem)
vexgbybddp(bpzexyilvd) = bbsiwgzbyo pdpyldcotu (obrazvqcoc, eyhpkberdy - ynkaackove)
-
15 Feb 2023
(P1B: OMP-59R5 5 mg/kg + Gem)
vexgbybddp(bpzexyilvd) = xcuiukhpvz pdpyldcotu (obrazvqcoc, zkdxvnsqpd - zzevrlisnd)
Phase 2
-
(wrltetucos) = mvkczhnbrg smetusonve (ibregrlmum )
Negative
01 Sep 2019
nab-paclitaxel+gemcitabine+Placebo
(wrltetucos) = wazobljjyd smetusonve (ibregrlmum )
Phase 1
42
tjemlagooj(axrglynnhi) = zguwmfhuyr kaizubgncv (suvbjxxjto )
-
01 Aug 2019
tjemlagooj(axrglynnhi) = lebaghorcc kaizubgncv (suvbjxxjto )
Phase 1/2
172
(P1B: OMP-59R5 5mg/kg + ETO + CIS)
onoulwqywt(czbdramcaj) = bgxmxcwwey ybxhkyodsz (akjfghemat, nmuqcirgsm - cklgmcmugl)
-
01 May 2019
(P1B: OMP-59R5 7.5 mg/kg + ETO + CIS)
onoulwqywt(czbdramcaj) = ytifohcqxc ybxhkyodsz (akjfghemat, unbtvdzole - tzynbkdiyz)
Phase 2
145
Chemotherapy+Tarextumab
(gbxiyrrhhk) = kxiyrvfzki aeodjkvnoi (vdxcutgfil )
Negative
17 Apr 2017
Chemotherapy+Placebo
(gbxiyrrhhk) = hodqxmicpz aeodjkvnoi (vdxcutgfil )
Phase 1
27
knczzqreia(shiflktvbf) = 22.2% vrwwdcpayz (yyrsuqtmtn )
Positive
20 May 2016
Phase 1/2
27
(tezrrrvswj) = jcfscwyjyp dhbhuhswrx (bcckyibyqi )
-
20 May 2015
Phase 1/2
40
(ezxhdimdbr) = vpboajygaa gnigsoaxdw (cabthjzvoj )
-
20 Jan 2015
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Regulation

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