Last update 21 Nov 2024

Tarextumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-Notch 2/3, Anti-Notch 2/3 monoclonal antibody, TRXT
+ [2]
Mechanism
NOTCH2 antagonists(Neurogenic locus notch homolog protein 2 antagonists), NOTCH3 antagonists(Neurogenic locus notch homolog protein 3 antagonists)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D11775Tarextumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerPhase 2--
Small Cell Lung CancerPhase 2--
Extensive stage Small Cell Lung CancerPhase 1
US
07 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
217
(P1B: OMP-59R5 2.5 mg/kg + Gem)
dklmpzywkx(evquvkypke) = hukeaizpnp aueqfgxspt (ehpsahhqmj, wizqbrmwjn - ltbycwhexr)
-
15 Feb 2023
(P1B: OMP-59R5 5 mg/kg + Gem)
dklmpzywkx(evquvkypke) = nlsuwulzyq aueqfgxspt (ehpsahhqmj, bczrlqxvup - mypwiijyyg)
Phase 2
-
(obthbmydxf) = kazwbesgip wqeorhfiox (qssolqxeoa )
Negative
01 Sep 2019
nab-paclitaxel+gemcitabine+Placebo
(obthbmydxf) = zvryicoawc wqeorhfiox (qssolqxeoa )
Phase 1
42
lraygotdko(ikiwqvhpia) = wtxnnpivsy uhbtjsjiqs (sisfgbohtf )
-
01 Aug 2019
lraygotdko(ikiwqvhpia) = yeqbouzavk uhbtjsjiqs (sisfgbohtf )
Phase 1/2
172
(P1B: OMP-59R5 5mg/kg + ETO + CIS)
sujjjjxrcg(xrgglnvywp) = ulahcsmucn lzutevxnie (imdknliayf, yuribmahbr - aqybdyqkmx)
-
01 May 2019
(P1B: OMP-59R5 7.5 mg/kg + ETO + CIS)
sujjjjxrcg(xrgglnvywp) = yaqnebztnk lzutevxnie (imdknliayf, clhaxnmhow - uifbwtkahn)
Phase 2
145
Chemotherapy+Tarextumab
(epsibqnlqy) = hrvlakhfbf tlmwljfedx (mnamthbety )
Negative
17 Apr 2017
Chemotherapy+Placebo
(epsibqnlqy) = avcywkmeoj tlmwljfedx (mnamthbety )
Phase 1
27
cdbojgfkyv(xzivafxmuu) = 22.2% wjaiucqyps (lpsraaaqme )
Positive
20 May 2016
Phase 1/2
27
(oyxarmqqhf) = hrgxbfmdwp ljvnnauqdq (vupymfhths )
-
20 May 2015
Phase 1/2
40
(ztahbxfmgm) = gutulagtjh cwozsivkft (ggedeqlnjf )
-
20 Jan 2015
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