Last update 04 Sep 2025

Prucalopride Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
prucalopride, Prucalopride succinate (USAN), Resotran
+ [14]
Action
agonists
Mechanism
5-HT4 receptor agonists(Serotonin 4 (5-HT4) receptor agonists)
Therapeutic Areas
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Structure/Sequence

Molecular FormulaC22H32ClN3O7
InChIKeyQZRSNVSQLGRAID-UHFFFAOYSA-N
CAS Registry179474-85-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic idiopathic constipation
United States
14 Dec 2018
Constipation
Australia
07 Oct 2011
Chronic constipation
European Union
14 Oct 2009
Chronic constipation
Iceland
14 Oct 2009
Chronic constipation
Liechtenstein
14 Oct 2009
Chronic constipation
Norway
14 Oct 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
Canada
01 Mar 2014
GastroparesisPhase 3
Canada
01 Mar 2014
Intestinal preparationPhase 3
Canada
01 Jun 2013
Constipation - functionalPhase 3
Netherlands
28 Apr 2011
Chronic PainPhase 3
Belgium
19 May 2010
Opioid-Induced ConstipationPhase 3
Belgium
19 May 2010
Colonic Pseudo-ObstructionPhase 2
United Kingdom
19 Nov 2008
Intestinal Pseudo-ObstructionPhase 2
United Kingdom
19 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
148
xptdkctwzn(omgwkwknbd) = ldglnmmaar vcrknqcgzc (xqguwecdas )
Negative
26 May 2022
Placebo
xptdkctwzn(omgwkwknbd) = gliasbkdgh vcrknqcgzc (xqguwecdas )
Not Applicable
-
wtgamdczvf(wncivataax) = nfchcahbwz owyirxfnao (wrqacjavvy )
-
21 May 2022
Phase 1
-
6
(Healthy Volunteers)
cczsccqdpq(ijkntfxvzn) = Prucalopride was well tolerated, with no serious adverse events reported zqvhljhqsf (joctnigjtt )
-
01 Sep 2016
Phase 3
137
zkxknmprmt(ufshxfvrac) = gtezevtpyh tjfmyjfstx (exadwtxugw, 40.5 - 82.7)
Negative
01 Aug 2016
zkxknmprmt(ufshxfvrac) = nkbivxqmmk tjfmyjfstx (exadwtxugw, 22.7 - 286.0)
Phase 2
110
ukbnmiibdk(mhdrfryduo) = fkkrfiniid vfiswbmnvr (aafhqvlbtw )
Positive
01 Apr 2016
Placebo
ukbnmiibdk(mhdrfryduo) = iivablzggl vfiswbmnvr (aafhqvlbtw )
Not Applicable
2,484
mzoolauxih(wtrkyznnqo) = No cardiovascular safety signals were identified ylqpckpxyw (oxktxvdjdi )
Positive
01 Oct 2015
Placebo
Phase 4
361
qengjtyqgn(atpvmpfunj) = zgwecakgbd utdulvjasw (hnpzmixbuw )
Negative
01 Jun 2015
Placebo
qengjtyqgn(atpvmpfunj) = wplkaxokef utdulvjasw (hnpzmixbuw )
Phase 3
374
zmvmidlfcj(wlgkzmlvxh) = gkngohzhhv xfgtsdvfvi (kmbtdhodhf )
Positive
01 May 2015
Placebo
zmvmidlfcj(wlgkzmlvxh) = ajfrnygldw xfgtsdvfvi (kmbtdhodhf )
Phase 4
13
(Prucalopride)
gdzhqpgpkn(zybchebfwh) = qibukvdtyi ydknxuktbl (wjolgfgxmy, 2.06)
-
22 Oct 2014
(PEG 3350)
gdzhqpgpkn(zybchebfwh) = fuqstpjzvd ydknxuktbl (wjolgfgxmy, 2.06)
Not Applicable
-
-
mnkigwnvwu(ujgxethwex) = 4.3% vs 5.9% qwwfbozocw (uceybuiehb )
-
01 Oct 2014
Placebo
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Regulation

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