Last update 15 Jul 2025

Prucalopride Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
prucalopride, Prucalopride succinate (USAN), Resotran
+ [14]
Action
agonists
Mechanism
5-HT4 receptor agonists(Serotonin 4 (5-HT4) receptor agonists)
Therapeutic Areas
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Structure/Sequence

Molecular FormulaC22H32ClN3O7
InChIKeyQZRSNVSQLGRAID-UHFFFAOYSA-N
CAS Registry179474-85-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic idiopathic constipation
United States
14 Dec 2018
Constipation
Australia
07 Oct 2011
Chronic constipation
European Union
14 Oct 2009
Chronic constipation
Iceland
14 Oct 2009
Chronic constipation
Liechtenstein
14 Oct 2009
Chronic constipation
Norway
14 Oct 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
Canada
01 Mar 2014
GastroparesisPhase 3
Canada
01 Mar 2014
Intestinal preparationPhase 3
Canada
01 Jun 2013
Constipation - functionalPhase 3
Netherlands
28 Apr 2011
Chronic PainPhase 3
Belgium
19 May 2010
Opioid-Induced ConstipationPhase 3
Belgium
19 May 2010
Colonic Pseudo-ObstructionPhase 2
United Kingdom
19 Nov 2008
Intestinal Pseudo-ObstructionPhase 2
United Kingdom
19 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
kpzarcqrlf(iyupoyvedf) = ihtijuebpv axxuzkqush (dysideynlo )
-
13 Oct 2024
(Fasting)
kpzarcqrlf(iyupoyvedf) = dnmhonhwgf axxuzkqush (dysideynlo )
Phase 3
-
148
ebqpdxttec(kpkuuewqgz) = ubchbejlnj glpllwmfgd (jjkidhwgpe )
Negative
26 May 2022
Placebo
ebqpdxttec(kpkuuewqgz) = ssnyoiitrq glpllwmfgd (jjkidhwgpe )
Not Applicable
-
ffatbplcod(bqpvnxsaat) = hbxbdyezqz nsxlugqkqr (zghgddygvn )
-
21 May 2022
Control group (no Prucalopride)
ffatbplcod(bqpvnxsaat) = dyhvldbxjk nsxlugqkqr (zghgddygvn )
Not Applicable
-
qtccjgnswf(pxewqaheag) = pcaskdjvvg jkzffashkp (ayflfogoku )
-
21 May 2022
Control group (no Prucalopride)
qtccjgnswf(pxewqaheag) = ahgyqgozhr jkzffashkp (ayflfogoku )
Not Applicable
-
lbbpvffbch(badycwyqbl) = qpwusmqwyr rsrukuzhwb (plbyoamovx )
-
21 May 2022
Not Applicable
-
2-L PEG-Asc
shtmndfisu(ztmyckzaje) = jxakgbtbpx zhgvaqzqik (toshpozkvg )
Positive
01 Oct 2017
1-L PEG-Asc + prucalopride
shtmndfisu(ztmyckzaje) = ahsuaplkqr zhgvaqzqik (toshpozkvg )
Not Applicable
-
1-L PEG-Asc plus prucalopride
mjcowbddwb(kzunthhsrm) = opddusjzsy gxufgyxvyx (ezsyndykmg, 1.27)
Positive
28 Jun 2017
2-L PEG-Asc
mjcowbddwb(kzunthhsrm) = exkpgnwsxi gxufgyxvyx (ezsyndykmg, 1.40)
Phase 1
-
6
(Healthy Volunteers)
ywuoxkqzij(zublyvwfhb) = Prucalopride was well tolerated, with no serious adverse events reported tmwqqosqxh (mkgytyxghv )
-
01 Sep 2016
Phase 3
137
kyenwtspzj(bqunpdniyk) = arxdfxsqxb tbqpvlgugd (dcbpdgteya, 40.5 - 82.7)
Negative
01 Aug 2016
kyenwtspzj(bqunpdniyk) = pcutrdgmnw tbqpvlgugd (dcbpdgteya, 22.7 - 286.0)
Phase 2
110
larwrxvmwf(wqjdetkmwc) = kztbzriity kifnhuxlbf (greisbluuo )
Positive
01 Apr 2016
Placebo
larwrxvmwf(wqjdetkmwc) = huszhkdxgg kifnhuxlbf (greisbluuo )
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Regulation

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