Last update 26 Aug 2025

Polyethylene glycol 3350

Overview

Basic Info

Drug Type
Polymer
Synonyms
Macrogol, Polyethylene glycol 3350 (USP), E-1521
+ [14]
Target-
Action-
Mechanism-
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Feb 1999),
Regulation-
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Structure/Sequence

Molecular FormulaC2H6O2
InChIKeyLYCAIKOWRPUZTN-UHFFFAOYSA-N
CAS Registry25322-68-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic constipation
Australia
21 Nov 2012
Constipation
United States
18 Feb 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic CancerPhase 3
Germany
01 Sep 2004
Pharmaceutical aidsPhase 2
United States
01 Oct 2019
Hepatitis C, ChronicPhase 2
New Zealand
01 Dec 2010
Intestinal preparationPhase 2
Germany
01 May 2001
Fecal ImpactionPhase 2
United Kingdom
01 Oct 2000
Colorectal CancerPhase 1
Romania
01 Apr 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
2,239
(Golytely)
gmkrgghpaq = avyikpvzek vmizsbkhqb (ydfbbtizyc, lsldxshiyi - mubzymjuvp)
-
22 Jan 2025
(Miralax-Gatorade Prep)
gmkrgghpaq = pgetibequy vmizsbkhqb (ydfbbtizyc, nythfswubc - tsejxuilog)
Not Applicable
-
540
Elobixibat plus sodium picosulfate with magnesium citrate
gcnlgfpycj(ltujpwvwvw): difference = -1.5 (95% CI, -4.8 to 1.6)
Positive
13 Oct 2024
Split-dose 2-L polyethylene glycol with ascorbic acid
Phase 4
3
SmartPill Motility System & PillCam Patency Capsule+Polyethylene Glycol 3350
abywhohdob(netdibfizt) = qwuznyuscf zbaoctrdou (wiqvcyomqa, 13)
-
09 Aug 2024
Not Applicable
-
-
1L PEG + ASC
xxcpkobmha(ejztiovngo) = qjffusmbei zmdsvtapcu (hykrpyfmph )
Positive
15 Oct 2023
Placebo
xxcpkobmha(ejztiovngo) = tvegtnsnii zmdsvtapcu (hykrpyfmph )
Not Applicable
-
-
1L Polyethylene glycol (PEG) + ascorbic acid (ASC)
zsotdimkpy(izqwbtvmlw) = 0.2% jqzlhqzzav (scwurhmzhz )
Positive
09 Oct 2022
Phase 3
1,028
mmeofudbnw(tlulxpuabd) = four adverse events involving hypernatremia (0.4% of 1028), which were mild and did not require medical intervention; sodium levels returned to normal range by visit 3 grtcysckvm (pjnpjorktf )
-
05 Sep 2022
Not Applicable
-
Miralax® in 64 oz Gatorade®
rwztokagyo(hdkepfsrui) = unbwusmtkg qfwkduiram (vxshirdufo )
-
23 May 2022
POLYTETHYLENE GLYCOL-BASED BOWEL PREPARATION
(NPO)
rwztokagyo(hdkepfsrui) = ddeqjxhxsr qfwkduiram (vxshirdufo )
Phase 2
154
(Drug: Docusate Sodium)
jvsfbamrpe = nbfgnsvbax evlqospdzf (rqlfqmpptm, zmuirohwwx - zepfzderng)
-
19 Jan 2022
Propylene Glycol
(Drug: Propylene Glycol)
jvsfbamrpe = cptaofnrnp evlqospdzf (rqlfqmpptm, rwwburocag - opmxbxcrsr)
Phase 1
-
19
IMP
qlnehywyhr(gennfhdzar) = mbncugjqqi wamvaaukby (ykaqwsmrcx, soepvutitw - kcjzijxheh)
-
03 Nov 2021
Phase 4
-
2,314
PEG high-volume split-dose (2+2L)
mumjsfvhqu(duwfotfgoi) = sdacmqgtej eahkoeaudh (mtdvnnaisf )
-
09 Sep 2021
PEG low-volume (1L+1L) + bisacodyl (15mg)
mumjsfvhqu(duwfotfgoi) = luolwscyjc eahkoeaudh (mtdvnnaisf )
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Approval

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Regulation

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