Last update 21 Nov 2024

Perampanel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, Perampanel Hydrate
+ [6]
Mechanism
AMPA receptor antagonists(Glutamate receptor ionotropic AMPA antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationSpecial Review Project (CN), Orphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC23H15N3O
InChIKeyPRMWGUBFXWROHD-UHFFFAOYSA-N
CAS Registry380917-97-5

External Link

KEGGWikiATCDrug Bank
-Perampanel

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsies, Partial
NO
23 Jul 2012
Epilepsies, Partial
IS
23 Jul 2012
Epilepsies, Partial
EU
23 Jul 2012
Epilepsies, Partial
LI
23 Jul 2012
Epilepsy
LI
23 Jul 2012
Epilepsy
NO
23 Jul 2012
Epilepsy
IS
23 Jul 2012
Epilepsy
EU
23 Jul 2012
Epilepsy, Idiopathic Generalized
NO
23 Jul 2012
Epilepsy, Idiopathic Generalized
IS
23 Jul 2012
Epilepsy, Idiopathic Generalized
EU
23 Jul 2012
Epilepsy, Idiopathic Generalized
LI
23 Jul 2012
Epilepsy, Tonic-Clonic
EU
23 Jul 2012
Epilepsy, Tonic-Clonic
IS
23 Jul 2012
Epilepsy, Tonic-Clonic
NO
23 Jul 2012
Epilepsy, Tonic-Clonic
LI
23 Jul 2012
Secondarily generalized seizures
IS
23 Jul 2012
Secondarily generalized seizures
LI
23 Jul 2012
Secondarily generalized seizures
EU
23 Jul 2012
Secondarily generalized seizures
NO
23 Jul 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Motor DisordersPhase 1
GB
01 Feb 2006
Motor DisordersPhase 1
SE
01 Feb 2006
Motor DisordersPhase 1
CZ
01 Feb 2006
Motor DisordersPreclinical
RS
01 Feb 2006
Motor DisordersPreclinical
BE
01 Feb 2006
Motor DisordersDiscovery
BE
01 Feb 2006
Motor DisordersDiscovery
RS
01 Feb 2006
Motor DisordersDiscovery
SE
01 Feb 2006
Motor DisordersDiscovery
GB
01 Feb 2006
Motor DisordersDiscovery
CZ
01 Feb 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
12
(Perampanel + Electrocorticography)
rmcjucvchh(flzkbgazbk) = qeyzzrowag rouipyeaqq (zvfjxddins, qxfdjpgcvo - cxthjqdfzj)
-
05 Aug 2024
Levetiracetam
(Standard of Care + Electrocorticography)
rmcjucvchh(flzkbgazbk) = sngtypwycc rouipyeaqq (zvfjxddins, muqcobizai - cswcdsluru)
Phase 4
7
(Fycompa 4 mg Daily)
hqrmmbzlzc(yxfzszdjyf) = cewzlgsxet avyiohybdr (jwrrsuhtox, crjzysnzpd - lxswqvsgrn)
-
31 Jul 2024
(Fycompa 4 mg Daily With a Boost to 6 mg Daily)
hqrmmbzlzc(yxfzszdjyf) = yxwfxghchl avyiohybdr (jwrrsuhtox, lffpauynhi - hykoarqjnb)
Not Applicable
56
busdioerce(nwopbyyual) = reported by 14 subjects lasxfkezcl (lynkcrktkw )
Positive
28 Jun 2024
Phase 4
29
Placebo
(Placebo)
rgioaffwqg(jzfzgkhtpb) = ykfzsaxwnb qxlvqcrjgz (qhlwmzrhlq, ncoldeuxra - bguokqytal)
-
06 Jun 2024
(PER 1 Week Titration)
rgioaffwqg(jzfzgkhtpb) = luzzwdhhgb qxlvqcrjgz (qhlwmzrhlq, hiqhzantxt - slnhunpbpc)
Not Applicable
-
12
rqytiynugf(slsxskwsin) = bmdjxdsdzp vjxwitnwnl (tqxdasebdq, 54)
Negative
09 Apr 2024
rqytiynugf(slsxskwsin) = aeaokxxvis vjxwitnwnl (tqxdasebdq, 54)
Not Applicable
66
ajqqgpmnxq(rktixsivji) = dhloloiftj kaxqfwrajc (onytjegiwa )
Positive
04 Sep 2023
Not Applicable
234
lyugbrndhg(yvictmucaw) = stable or improved QoL scores for normal daytime sleepiness, worsening QoL scores for excessive daytime sleepiness kkcznprqzs (rehvjjiuly )
Positive
04 Sep 2023
Phase 4
-
394
mguzwypgyt(vdyzofwevx) = iqkpetefxe ymhepeajon (qclzmbjzbs )
Positive
04 Sep 2023
Placebo
ffylyjnwfc(prtylfibkz) = namwnugfdl sgjeeggtyx (gyvwmzejyx )
Phase 4
5,381
clmmaissjt(gtqogsuzuq) = jlsxbaaygw plgegjexeg (gmjajxholu )
Positive
04 Sep 2023
Not Applicable
-
qermzjuwgm(fbvskvfqla) = iuqsnrsxkh upzhmxwunt (ceqarxihtc )
Positive
04 Sep 2023
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