Last update 04 Nov 2024

Perampanel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, Perampanel Hydrate, BIOS2207
+ [6]
Mechanism
AMPA receptor antagonists(Glutamate receptor ionotropic AMPA antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC23H15N3O
InChIKeyPRMWGUBFXWROHD-UHFFFAOYSA-N
CAS Registry380917-97-5

External Link

KEGGWikiATCDrug Bank
-Perampanel

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsies, Partial
EU
23 Jul 2012
Epilepsies, Partial
IS
23 Jul 2012
Epilepsies, Partial
LI
23 Jul 2012
Epilepsies, Partial
NO
23 Jul 2012
Epilepsy
EU
23 Jul 2012
Epilepsy
IS
23 Jul 2012
Epilepsy
LI
23 Jul 2012
Epilepsy
NO
23 Jul 2012
Epilepsy, Idiopathic Generalized
EU
23 Jul 2012
Epilepsy, Idiopathic Generalized
IS
23 Jul 2012
Epilepsy, Idiopathic Generalized
LI
23 Jul 2012
Epilepsy, Idiopathic Generalized
NO
23 Jul 2012
Epilepsy, Tonic-Clonic
EU
23 Jul 2012
Epilepsy, Tonic-Clonic
IS
23 Jul 2012
Epilepsy, Tonic-Clonic
LI
23 Jul 2012
Epilepsy, Tonic-Clonic
NO
23 Jul 2012
Secondarily generalized seizures
EU
23 Jul 2012
Secondarily generalized seizures
IS
23 Jul 2012
Secondarily generalized seizures
LI
23 Jul 2012
Secondarily generalized seizures
NO
23 Jul 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lennox Gastaut SyndromePhase 3
US
13 Dec 2016
Lennox Gastaut SyndromePhase 3
JP
13 Dec 2016
Lennox Gastaut SyndromePhase 3
AU
13 Dec 2016
Lennox Gastaut SyndromePhase 3
BE
13 Dec 2016
Lennox Gastaut SyndromePhase 3
CZ
13 Dec 2016
Lennox Gastaut SyndromePhase 3
IN
13 Dec 2016
Lennox Gastaut SyndromePhase 3
KR
13 Dec 2016
SeizuresPhase 3
US
30 Apr 2008
SeizuresPhase 3
AR
30 Apr 2008
SeizuresPhase 3
BR
30 Apr 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
12
(Perampanel + Electrocorticography)
omoabusxpk(shhvqmbcmb) = kgunqxyyzq evmimbwulu (yzeumowgqx, acetfiaglw - upcowcugsc)
-
05 Aug 2024
Levetiracetam
(Standard of Care + Electrocorticography)
omoabusxpk(shhvqmbcmb) = txgbokmuwt evmimbwulu (yzeumowgqx, ujidakgazj - hojmqovdrj)
Phase 4
7
(Fycompa 4 mg Daily)
bqqghnmdji(hdvwujwwky) = jpnlqcmdab nyaorykthb (hkwjzgpjjh, fkdyzljmry - ydncsgihvi)
-
31 Jul 2024
(Fycompa 4 mg Daily With a Boost to 6 mg Daily)
bqqghnmdji(hdvwujwwky) = tsvweqlshz nyaorykthb (hkwjzgpjjh, dakxvxvexv - eretmqbxhl)
Phase 4
29
Placebo
(Placebo)
cnsjgvcjgc(yxhsyocfis) = trfwgiyfzd jthmxcxops (qznoyxptcu, xtzmmsxefu - hbqsivjeiv)
-
06 Jun 2024
(PER 1 Week Titration)
cnsjgvcjgc(yxhsyocfis) = dfcjcuegfb jthmxcxops (qznoyxptcu, lfejwzyjib - rjqyvxsubb)
Phase 4
-
297
Perampanel
ygwtrknsnf(ztdkumisdl) = 4.9% jjdiytacef (xcmujuzkwh )
Positive
01 Oct 2023
Not Applicable
18
jlbxukvqci(ikgojccakn) = ymccirnqhy ddkegeqpvb (gxmawwdksf, 48.35)
Positive
04 Sep 2023
Not Applicable
-
urunuskoci(ctnaswogup) = djmtbxgftw fgnmvdcohb (scpeqxpyoy )
-
04 Sep 2023
Not Applicable
-
ayfiqncmqm(nrhlskivdl) = pjphyrhwjb iqhjelmold (ffgzzysmgg )
-
04 Sep 2023
Phase 4
54
tqjtelvgdk(fxodorlqtf) = Incidences of TEAEs were 88.9% iwusabqnzq (skgigchnvk )
Positive
04 Sep 2023
Perampanel first adjunctive therapy
Phase 4
-
394
dbqatxesax(kvfeuifobd) = mcpoaxiehh rvqudagfdp (inbsdoaxog )
Positive
04 Sep 2023
Placebo
olyvhibaca(hywhiacjjz) = vpfetxeykn hnsnycnidc (amimnykjbq )
Not Applicable
66
kefzxsaftg(fsdkgrklhb) = msutewngso szhpeefchs (fuhhmfkrlz )
Positive
04 Sep 2023
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