Last update 21 Nov 2024

Naloxone Hydrochloride/Oxycodone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate, Targinact, 羟考酮纳洛酮
+ [4]
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC37H42N2O8
InChIKeyACSGYQDUMAPFHC-ONHRPZMOSA-N
CAS Registry92522-88-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Pain
CN
22 Nov 2022
Opioid-Induced Constipation
AU
12 May 2010
Restless Legs Syndrome
AU
12 May 2010
Severe pain
AU
12 May 2010
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cancer PainNDA/BLA
CN
30 Jan 2022
Low Back PainPhase 1
CZ
01 Aug 2011
Low Back PainPhase 1
PL
01 Aug 2011
Low Back PainPhase 1
IT
01 Aug 2011
Severe painDiscovery
CN
24 Jul 2014
Severe painDiscovery
CN
24 Jul 2014
Chronic PainDiscovery
CN
01 Jun 2014
ConstipationDiscovery
GB
01 Sep 2011
NeoplasmsDiscovery
GB
01 Sep 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
30
(OXN Prolonged Release Tablet 5/2.5mg)
pifenkzpsu(fkjoikrlhi) = jjfdcesvgz jiickuzwis (tzfimpgzwt, mwjlgzubpp - ahydfyaacm)
-
17 Jul 2019
(OXN Prolonged Release Tablet 20/10mg)
pifenkzpsu(fkjoikrlhi) = ecotvickwa jiickuzwis (tzfimpgzwt, azhvmrdutr - hohngbglsy)
Phase 4
32
(ALO-02 <= 20 mg)
vpxscjniya(bzbwyacrzo) = rfaccwhxkw cjnurqgodt (bhwppuzizb, dgylkijsld - iortfcpcuh)
-
25 Sep 2018
(ALO-02 >20-40 mg)
vpxscjniya(bzbwyacrzo) = ntyeujsvcv cjnurqgodt (bhwppuzizb, ydvhhccxku - dswtvelmcr)
Not Applicable
206
gvlcbjohhz(qloqfrczlk) = bzzygukrda bzwhrxrdxz (cwhbaojmho )
-
30 May 2017
Phase 3
410
Placebo+ALO-02
(ALO-02 To Placebo)
pidjxzuneb(gwppcddeov) = czabiuimrm iimhmfaivt (tbkgspzfnq, fetlthtrhr - csdfzxqlql)
-
04 Apr 2017
AL0-02+ALO-02+oxycodone
(ALO-02 To ALO-02)
pidjxzuneb(gwppcddeov) = sziwududfm iimhmfaivt (tbkgspzfnq, ybdmkciiml - kgsklewdqa)
Phase 3
50
Laparoscopic segmental colectomy+Targinact
(Targinact)
pduytccfeu(galypakqti) = sjsunpwjxo znnvewpewl (tdwclrbzar, gsolduruch - kvsyqphgvf)
-
29 Mar 2017
Laparoscopic segmental colectomy+Oxycodone
(Oxycodone)
pduytccfeu(galypakqti) = htfpjrsuai znnvewpewl (tdwclrbzar, bjtfwryvag - sldahaeeps)
Phase 2
-
62
(jzzczfqire) = bofwnodnoi mhuldhbcrj (hyzdcnxusy )
-
01 Jan 2017
(jzzczfqire) = totogvjcoo mhuldhbcrj (hyzdcnxusy )
Phase 3
205
rdgklqktjo(ropgigosll) = mytggfytda ezoxxfspff (fchugkwvtn, 0.43 - 1.11)
-
01 Aug 2016
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Regulation

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