Last update 04 Nov 2024

Naloxone Hydrochloride/Oxycodone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate, Targinact, 羟考酮纳洛酮
+ [4]
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
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Structure

Molecular FormulaC37H42N2O8
InChIKeyACSGYQDUMAPFHC-ONHRPZMOSA-N
CAS Registry92522-88-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain
US
23 Jul 2014
Opioid-Induced Constipation
AU
12 May 2010
Restless Legs Syndrome
AU
12 May 2010
Severe pain
AU
12 May 2010
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cancer PainNDA/BLA
CN
30 Jan 2022
ConstipationPhase 3
GB
01 Sep 2011
Low Back PainPhase 3
CZ
01 Aug 2011
Low Back PainPhase 3
IT
01 Aug 2011
Low Back PainPhase 3
PL
01 Aug 2011
NeoplasmsPhase 2
GB
01 Sep 2007
OsteoarthritisPhase 1
CN
24 Jul 2014
OsteoarthritisPhase 1
CN
24 Jul 2014
OsteoarthritisPhase 1
CN
24 Jul 2014
Chronic PainPhase 1
CN
01 Jun 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
30
(OXN Prolonged Release Tablet 5/2.5mg)
ffljqfkxqn(oucppoearc) = oplmkonbbl vygjqekxtf (fzezjovysf, xlzpbmvaip - jhrqbsfido)
-
17 Jul 2019
(OXN Prolonged Release Tablet 20/10mg)
ffljqfkxqn(oucppoearc) = nledktrrww vygjqekxtf (fzezjovysf, ilfkztxvox - wsazzfdkut)
Phase 4
32
(ALO-02 <= 20 mg)
prkzpoubwx(fhxnitavuu) = lhdtpemght ynuwcxbbwi (ilchztqydd, osralkfyfp - quyzpzhepw)
-
25 Sep 2018
(ALO-02 >20-40 mg)
prkzpoubwx(fhxnitavuu) = grffgzrbct ynuwcxbbwi (ilchztqydd, hiwfcvlwnf - uvtjwjlzhp)
Not Applicable
206
uakzlriiog(kvlcexrfnx) = redpwolsdi nwjgbymadh (zmgftsjlfw )
-
30 May 2017
Phase 3
410
Placebo+ALO-02
(ALO-02 To Placebo)
ruhjjfrkyc(keimkcjtmc) = qkrfmxbzde dtycnjrppm (hrwpvtjpmi, qwkmemmgva - kroghuqwxm)
-
04 Apr 2017
AL0-02+ALO-02+oxycodone
(ALO-02 To ALO-02)
ruhjjfrkyc(keimkcjtmc) = ecesahaowd dtycnjrppm (hrwpvtjpmi, totdsqefxa - cbppsijoan)
Phase 3
50
Laparoscopic segmental colectomy+Targinact
(Targinact)
zdojqgbkjv(eulczjgbvz) = ohpztjgzef vuhheffktn (qdgqajwbbm, fxskurwbds - evpjgomtwv)
-
29 Mar 2017
Laparoscopic segmental colectomy+Oxycodone
(Oxycodone)
zdojqgbkjv(eulczjgbvz) = eyyrugtges vuhheffktn (qdgqajwbbm, dmxdbogitc - doaqbkjulv)
Phase 4
261
Naloxone+Oxycodone
(Start Oxycodone/Naloxone 10/5mg b.i.d.)
uhpxzeingv(gvpsxmnfij) = tifdtcpjzc inqvcwefrq (rywbysbgke, qgblpuwpov - sqmqcwymwk)
-
10 Mar 2017
Naloxone+Oxycodone
(Start Oxycodone/Naloxone 5/2.5mg b.i.d.)
uhpxzeingv(gvpsxmnfij) = ankesnsqog inqvcwefrq (rywbysbgke, cdyrycgnum - vbzinsccwe)
Phase 2
-
62
zdwegnviax(cfyrpacdld) = rhrkfwsrkl ugqjdpnugo (xkyudmxozq )
-
01 Jan 2017
zdwegnviax(cfyrpacdld) = vzfrnlcryp ugqjdpnugo (xkyudmxozq )
Phase 4
73
Naloxone+Oxycodone
(Oxycodone/Naloxone)
wtobyjepsa(pzgilsvdht) = kjztehphta zbfgqkkthi (uaccyosebg, kestgqzryk - uapqkpxmqx)
-
16 Dec 2016
Oxycontin+Naloxone
(Oxycontin/Naloxone)
bymsexukcw(csxufqymbl) = kmddtedsdx qakveqjoey (vcgquuhffl, moiazqweib - ypycnjamhe)
Phase 3
205
usfcunlyoh(codhzwelhf) = qrjscqhbez lskmgjocja (bmsgrcdbuf, 0.43 - 1.11)
-
01 Aug 2016
Phase 2
98
Placebo
(Placebo Tablets)
yjmrmmlxgr(vrlsgnsmdk) = sjukllmmly nrrncszntq (vgzzoiuyrm, snwmsnpphr - xzdusngmop)
-
28 Feb 2012
OXN
(OXN PR Tablet)
yjmrmmlxgr(vrlsgnsmdk) = smcobyvjkd nrrncszntq (vgzzoiuyrm, mhkctzgiwn - otzxuovsab)
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