Drug Type Small molecule drug |
Synonyms Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate, Targinact, 羟考酮纳洛酮 + [4] |
Target |
Mechanism Opioid receptors agonists(Opioid receptors agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date AU (12 May 2010), |
Regulation- |
Molecular FormulaC37H42N2O8 |
InChIKeyACSGYQDUMAPFHC-ONHRPZMOSA-N |
CAS Registry92522-88-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Pain | US | 23 Jul 2014 | |
Opioid-Induced Constipation | AU | 12 May 2010 | |
Restless Legs Syndrome | AU | 12 May 2010 | |
Severe pain | AU | 12 May 2010 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Cancer Pain | NDA/BLA | CN | 30 Jan 2022 | |
Constipation | Phase 3 | GB | 01 Sep 2011 | |
Low Back Pain | Phase 3 | CZ | 01 Aug 2011 | |
Low Back Pain | Phase 3 | IT | 01 Aug 2011 | |
Low Back Pain | Phase 3 | PL | 01 Aug 2011 | |
Neoplasms | Phase 2 | GB | 01 Sep 2007 | |
Osteoarthritis | Phase 1 | CN | 24 Jul 2014 | |
Osteoarthritis | Phase 1 | CN | 24 Jul 2014 | |
Osteoarthritis | Phase 1 | CN | 24 Jul 2014 | |
Chronic Pain | Phase 1 | CN | 01 Jun 2014 |
Phase 1 | 30 | (OXN Prolonged Release Tablet 5/2.5mg) | ffljqfkxqn(oucppoearc) = oplmkonbbl vygjqekxtf (fzezjovysf, xlzpbmvaip - jhrqbsfido) View more | - | 17 Jul 2019 | ||
(OXN Prolonged Release Tablet 20/10mg) | ffljqfkxqn(oucppoearc) = nledktrrww vygjqekxtf (fzezjovysf, ilfkztxvox - wsazzfdkut) View more | ||||||
Phase 4 | 32 | (ALO-02 <= 20 mg) | prkzpoubwx(fhxnitavuu) = lhdtpemght ynuwcxbbwi (ilchztqydd, osralkfyfp - quyzpzhepw) View more | - | 25 Sep 2018 | ||
(ALO-02 >20-40 mg) | prkzpoubwx(fhxnitavuu) = grffgzrbct ynuwcxbbwi (ilchztqydd, hiwfcvlwnf - uvtjwjlzhp) View more | ||||||
Not Applicable | 206 | uakzlriiog(kvlcexrfnx) = redpwolsdi nwjgbymadh (zmgftsjlfw ) View more | - | 30 May 2017 | |||
Phase 3 | 410 | Placebo+ALO-02 (ALO-02 To Placebo) | ruhjjfrkyc(keimkcjtmc) = qkrfmxbzde dtycnjrppm (hrwpvtjpmi, qwkmemmgva - kroghuqwxm) View more | - | 04 Apr 2017 | ||
(ALO-02 To ALO-02) | ruhjjfrkyc(keimkcjtmc) = ecesahaowd dtycnjrppm (hrwpvtjpmi, totdsqefxa - cbppsijoan) View more | ||||||
Phase 3 | 50 | Laparoscopic segmental colectomy+Targinact (Targinact) | zdojqgbkjv(eulczjgbvz) = ohpztjgzef vuhheffktn (qdgqajwbbm, fxskurwbds - evpjgomtwv) View more | - | 29 Mar 2017 | ||
Laparoscopic segmental colectomy+Oxycodone (Oxycodone) | zdojqgbkjv(eulczjgbvz) = eyyrugtges vuhheffktn (qdgqajwbbm, dmxdbogitc - doaqbkjulv) View more | ||||||
Phase 4 | 261 | Naloxone+Oxycodone (Start Oxycodone/Naloxone 10/5mg b.i.d.) | uhpxzeingv(gvpsxmnfij) = tifdtcpjzc inqvcwefrq (rywbysbgke, qgblpuwpov - sqmqcwymwk) View more | - | 10 Mar 2017 | ||
Naloxone+Oxycodone (Start Oxycodone/Naloxone 5/2.5mg b.i.d.) | uhpxzeingv(gvpsxmnfij) = ankesnsqog inqvcwefrq (rywbysbgke, cdyrycgnum - vbzinsccwe) View more | ||||||
Phase 2 | - | 62 | zdwegnviax(cfyrpacdld) = rhrkfwsrkl ugqjdpnugo (xkyudmxozq ) View more | - | 01 Jan 2017 | ||
zdwegnviax(cfyrpacdld) = vzfrnlcryp ugqjdpnugo (xkyudmxozq ) View more | |||||||
Phase 4 | 73 | Naloxone+Oxycodone (Oxycodone/Naloxone) | wtobyjepsa(pzgilsvdht) = kjztehphta zbfgqkkthi (uaccyosebg, kestgqzryk - uapqkpxmqx) View more | - | 16 Dec 2016 | ||
Oxycontin+Naloxone (Oxycontin/Naloxone) | bymsexukcw(csxufqymbl) = kmddtedsdx qakveqjoey (vcgquuhffl, moiazqweib - ypycnjamhe) View more | ||||||
Phase 3 | 205 | usfcunlyoh(codhzwelhf) = qrjscqhbez lskmgjocja (bmsgrcdbuf, 0.43 - 1.11) | - | 01 Aug 2016 | |||
Phase 2 | 98 | Placebo (Placebo Tablets) | yjmrmmlxgr(vrlsgnsmdk) = sjukllmmly nrrncszntq (vgzzoiuyrm, snwmsnpphr - xzdusngmop) View more | - | 28 Feb 2012 | ||
OXN (OXN PR Tablet) | yjmrmmlxgr(vrlsgnsmdk) = smcobyvjkd nrrncszntq (vgzzoiuyrm, mhkctzgiwn - otzxuovsab) View more |