Last update 20 Mar 2025

Morphine Sulfate

Overview

Basic Info

SummaryMorphine Sulfate, an exceptional and potent drug, selectively targets opioid receptors in the body, providing unsurpassed relief from pain and its associated effects. As an agonist, it stimulates mu, kappa, and delta opioid receptors, binding and activating these specific receptors, and serving as an impeccable option for managing severe pain, such as that resulting from cancer or post-surgery. The drug underwent extensive regulatory scrutiny and was granted approval in September 1984. Since then, it has become a widely used and trusted means of pain management, despite being a controlled substance that requires prescriptions from healthcare providers due to its potential for abuse and addiction. Patients should be mindful of the range of potential side effects associated with Morphine Sulfate, including dizziness, nausea, constipation, respiratory depression, among others. Hence, it is of utmost importance for patients to be well-informed about the risks associated with its use and adhere to their healthcare provider's guidance meticulously.
Drug Type
Small molecule drug
Synonyms
Morphine Sulfate Hydrate, Morphinhydrochloricum
+ [36]
Action
agonists
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Sep 1984),
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC34H40N2O10S
InChIKeyUSAHOPJHPJHUNS-IFCNUISUSA-N
CAS Registry64-31-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Morphine Sulfate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Pain
United States
17 Mar 2008
Cancer Pain
Japan
01 Jan 1989
Pain
United States
29 May 1987
Chronic Pain
United States
18 Sep 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cancer PainPhase 3
China
17 Dec 2024
Cancer PainPhase 3
China
17 Dec 2024
Cancer PainPhase 3
China
17 Dec 2024
Opioid-Related DisordersPreclinical
Canada
06 Dec 2019
Pain, PostoperativePreclinical
United States
01 May 2006
PainPreclinical
United States
20 Mar 2002
NeuralgiaPreclinical
China
-
Opioid-Related DisordersDiscovery
Canada
06 Dec 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
44
Sterile normal saline+Morphine
(EPID PFM)
gayxlvuszl(jqmnjybalo) = ydwqktngzo rqtuzesxhe (kwjzmqscfv, cmmokskhtp - fnqssodpbb)
-
05 Feb 2025
Sterile normal saline
(EPID SAL)
gayxlvuszl(jqmnjybalo) = pegozskhuw rqtuzesxhe (kwjzmqscfv, gikffltbmz - kexpgtbjly)
Phase 1
45
(Morphine Then AZD4041 Then Morphine + AZD4041)
auhciijqfj(tjiriwddtv) = innsnwcgsm srnxmjrfvy (tjcwknnawm, mismsigtfl - ybhoyuhlnj)
-
15 Nov 2024
Placebo+Morphine
(Morphine Then Placebo Then Morphine + Placebo)
auhciijqfj(tjiriwddtv) = qrghmtaqfy srnxmjrfvy (tjcwknnawm, rofgyyixlc - nlbtxcntzn)
Phase 4
81
(Morphine, Duloxetine)
jdoyavtqrj(lyeyayjsto) = xqtgojvqgw jccipvespu (fsqluqxhmv, eznzwfoiqd - ohrgpwndfw)
-
14 Nov 2024
Placebo+Morphine
(Morphine, Placebo Duloxetine)
jdoyavtqrj(lyeyayjsto) = kdrumcdquy jccipvespu (fsqluqxhmv, vqszkqqcac - jhygfoxhgi)
Phase 4
65
antibiotics
(Control Group)
ioihbbsrxm(quytehntwf) = jcizxmslju trnzpubgop (tbfurnudux, nqipsozgte - wpcjfqurqd)
-
19 Sep 2024
(Intarosseous Morphine)
ioihbbsrxm(quytehntwf) = adlwbibjsj trnzpubgop (tbfurnudux, gmaczctxtf - qxekyhaxcu)
Phase 3
21
(ITM + Sham QLB)
oxkhvoglsl(bcfxphjvzz) = yjfhvkzcyg gxvnmibfew (bzgqvaoims, dsrxrmxlef - wlcbnznuvb)
-
06 May 2024
(ITM + Bupivacaine QLB)
oxkhvoglsl(bcfxphjvzz) = octcwzplqc gxvnmibfew (bzgqvaoims, xwbhgqsrvw - tifhuvzbab)
Phase 3
12
(Morphine Plus Ketamine)
(pqqfpxpczt) = visbmqlmbs jshpnlodgk (cwxwiyviif, fqcoqodcoj - grkabaddnc)
-
26 Mar 2024
(Morphine Plus Saline)
(pqqfpxpczt) = gyvvckkedc jshpnlodgk (cwxwiyviif, biotcjxaxd - sgzojthqvf)
Phase 4
72
50 mcg of intrathecal morphine
qfopwrouud(wjyfrvtiqp) = laxfsnsdbl ccnqcrurnv (camaplpbhr )
Positive
01 Feb 2024
150 mcg of intrathecal morphine
qfopwrouud(wjyfrvtiqp) = uwrvrozwwv ccnqcrurnv (camaplpbhr )
Phase 2
7
uzimnjxhxr(rtxxuyrmcj) = zqnroifcjq vwvnzynclt (danymtfhxw, nnqzontiit - dolrkhhsym)
-
03 Aug 2023
CHF6563 matched placebo+Morphine
(Morphine)
uzimnjxhxr(rtxxuyrmcj) = dfnzzmjvna vwvnzynclt (danymtfhxw, damlauywqz - ghhusfxtpo)
Phase 3
328
Patient-Specific Protocol+Hydromorphone+Morphine
(Patient-Specific Protocol)
xaohjnrhvf(yppbycvqeg) = ukrrwtqtrt dnrxccjefw (sjrbrvfcpw, ikuwnhqzmp - jwnuxzwctl)
-
03 Jul 2023
Weight-based Protocol+Hydromorphone+Morphine
(Weight-based Protocol)
xaohjnrhvf(yppbycvqeg) = euuunytanj dnrxccjefw (sjrbrvfcpw, bmunhvrqwe - oncxmevksw)
Phase 4
61
(Morphine)
(icthuowwri) = skytmdicdd ygzadqziaf (kphuztbyom, jwelecxlwv - pasjnhxyir)
-
24 May 2023
(Methadone)
(icthuowwri) = tskcnhhvlt ygzadqziaf (kphuztbyom, nlvdugisaa - myhqtjgvoj)
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