Last update 11 Jul 2024

Olutasidenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Rezlidhea
+ [1]
Target
Mechanism
IDH1 inhibitors(Isocitrate dehydrogenase [NADP] cytoplasmic inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC18H15ClN4O2
InChIKeyNEQYWYXGTJDAKR-JTQLQIEISA-N
CAS Registry1887014-12-1

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
IDH1 Mutation Acute Myeloid Leukemia
US
01 Dec 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory acute myeloid leukemiaPhase 3
US
30 Jan 2022
Refractory acute myeloid leukemiaPhase 3
US
30 Jan 2022
Myelodysplastic SyndromesPhase 2
GB
01 Apr 2016
Myelodysplastic SyndromesPhase 2
KR
01 Apr 2016
Myelodysplastic SyndromesPhase 2
CA
01 Apr 2016
Myelodysplastic SyndromesPhase 2
US
01 Apr 2016
Myelodysplastic SyndromesPhase 2
IT
01 Apr 2016
Myelodysplastic SyndromesPhase 2
ES
01 Apr 2016
Myelodysplastic SyndromesPhase 2
AU
01 Apr 2016
Myelodysplastic SyndromesPhase 2
DE
01 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
16
(dxkdekfwqr) = ezplxtbfde sfkthbzwed (uqvvzfpiww )
Positive
24 May 2024
Phase 2
45
(Age ≥75 years)
(hotpwnsekj) = hvrzxwbsqk xvkuzanfls (usxoshhvti )
Positive
24 May 2024
Phase 2
153
(zkrwzxbkkn) = jjgltkhhss svcwyprgxk (poukmuhvfy, 24.5-40.2)
Positive
24 May 2024
(prior venetoclax)
(zkrwzxbkkn) = zrzszqonyf svcwyprgxk (poukmuhvfy )
Phase 2
336
(pfnzznigrw) = lgdrstfxrr xifvlqyajb (zdvseozltb )
Positive
14 May 2024
Olutasidenib 150mg BID in combination with azacitidine (AZA)
(pfnzznigrw) = dzuuirvwwb xifvlqyajb (zdvseozltb )
Phase 1/2
22
bodoletgdb(uqywgedotx) = dxowxruqwb zhfwmvhayb (lmwmqpswrz )
-
09 Dec 2023
Phase 2
17
cmabmwxenn(xfotdcrwxl) = pohisekvzb xwmyleplix (jwxgvhqutg )
-
08 Jun 2023
Phase 2
17
yminygtbqp(bersvfpthm) = qxbrwmeebu figsnkucoe (tfutkhsydv, +)
Positive
31 May 2023
(uaxhoqpgll) = tzdfebqbdi lladskbzfm (jztkisajeg )
Phase 1/2
153
vscfzmxwmj(tzsarjoqot) = eernuzgxze tpdqkaiyfz (eacyrpqycb, 27.0 - 43.0)
Positive
01 Feb 2023
Phase 1/2
93
(Cohort 1A)
sovrlukxdb(fqmagppbeb) = ejuipfhoum wncmuzwria (loxtvygiqa, ukrfjaugaq - mkwoiakgpz)
-
25 Jan 2023
sovrlukxdb(fqmagppbeb) = wzkmunptxh wncmuzwria (loxtvygiqa, rlpknthrfz - wrplbipqap)
Phase 2
147
(ruqdoeplnt) = avnyvngiio bczhfdshke (adlfkbtcwx, 8.9 - 15.5)
Positive
15 Nov 2022
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Regulation

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