A Multicenter, Placebo-controlled Clinical Study of Berberine Hydrochloride in Preventing Recurrence and Carcinogenesis After Endoscopic Removal of Colorectal Adenomas：6-year Retrospective Follow-up Data

Colorectal cancer (CRC) is a common malignancy of the digestive tract, which constitutes a major public health burden. Almost 90% of CRC cases progress from precursor adenomatous polyps through adenoma-carcinoma sequence. Endoscopic detection and removal of colorectal adenoma (CRA) could reduce the incidence and mortality risk of CRC, but the recurrence rate is still high. Therefore, chemoprevention is quite important, not only solve the urgent public health problem, but also be cost-effective.
In 2020, the investigators published a multicenter, randomized, double-blind, placebo-controlled clinical study (NCT02226185) in the Lancet Gastroenterology & Hepatology. The result concluded that oral BBR for 2 years significantly reduced recurrence after endoscopic removal of CRA (RR 0.77, 95%CI 0.66-0.91; p=0.001). BBR also has a significant preventive effect on all polypoid lesions, including adenomas and serrated lesions (adjusted RR 0.78, 95%CI 0.66-0.91; p=0.002) . Does BBR still have a long-term protective effect on the recurrence of CRA after discontinuation? That's what the investigators concerned.
The present study is performed to observe and compare retrospectively the recurrence rate of CRAs in patients of the original BBR RCT study (NCT02226185) within 6 years after discontinuation of medication, including the overall recurrence rate of traditional adenomas within the first year, 1-3 years, 3-6 years, and the entire follow-up period of 6 years. The aim is to evaluate the long-term efficacy of BBR in preventing recurrence and carcinogenesis after endoscopic resection of CRAs.

Start Date04 Oct 2024

Sponsor / Collaborator

Shanghai Jiao Tong University School of Medicine

[+4]

NCT04918667 / Not yet recruitingPhase 1

A Phase I, Randomized, Crossover, Double-blind, Pharmacokinetic Study of Berberine Released From Cyclodextrin in Healthy Volunteers

In this study, we will evaluate the relative bioavailability of Berberine (BB) from capsules containing Indian Barberry (Berberis aristate DC.) Bark and Root Extract in the blood plasma of healthy subjects after oral administration of:
A. Capsules containing Berberine and GCD (BBA Berberine MetX™ Ultra Absorption, 250 mg) B. Capsules containing Berberine (BB, Berberine MetX™, 500 mg) - (reference product).

Start Date01 Sep 2024

Sponsor / Collaborator

Europharma AS

[+2]

ChiCTR2400083889 / SuspendedEarly Phase 1IIT

Curative effect of berberine hydrochloride on diabetic nephropathy

Start Date15 May 2024

Sponsor / Collaborator

The First Hospital of Jilin University

100 Clinical Results associated with Berberine Chloride Hydrate

100 Translational Medicine associated with Berberine Chloride Hydrate

100 Patents (Medical) associated with Berberine Chloride Hydrate

436

Literatures (Medical) associated with Berberine Chloride Hydrate

01 Dec 2024·Applied Microbiology and Biotechnology

Epiberberine: a potential rumen microbial urease inhibitor to reduce ammonia release screened by targeting UreG

Article

Author: Wang, Jiaqi ; Zhao, Shengguo ; He, Yue ; Zheng, Nan ; Xiong, Zhanbo ; Zhang, Xiaoyin

AbstractRumen microbial urease inhibitors have been proposed for regulating nitrogen emission and improving nitrogen utilization efficiency in ruminant livestock industry. However, studies on plant-derived natural inhibitors of rumen microbial urease are limited. Urease accessory protein UreG, plays a crucial role in facilitating urease maturation, is a new target for design of urease inhibitor. The objective of this study was to select the potential effective inhibitor of rumen microbial urease from major protoberberine alkaloids in Rhizoma Coptidis by targeting UreG. Our results showed that berberine chloride and epiberberine exerted superior inhibition potential than other alkaloids based on GTPase activity study of UreG. Berberine chloride inhibition of UreG was mixed type, while inhibition kinetics type of epiberberine was uncompetitive. Furthermore, epiberberine was found to be more effective than berberine chloride in inhibiting the combination of nickel towards UreG and inducing changes in the second structure of UreG. Molecular modeling provided the rational structural basis for the higher inhibition potential of epiberberine, amino acid residues in G1 motif and G3 motif of UreG formed interactions with D ring of berberine chloride, while interacted with A ring and D ring of epiberberine. We further demonstrated the efficacy of epiberberine in the ruminal microbial fermentation with low ammonia release and urea degradation. In conclusion, our study clearly indicates that epiberberine is a promising candidate as a safe and effective inhibitor of rumen microbial urease and provides an optimal strategy and suitable feed additive for regulating nitrogen excretion in ruminants in the future.Key points• Epiberberine is the most effective inhibitor of rumen urease from Rhizoma Coptidis.• Urease accessory protein UreG is an effective target for design of urease inhibitor.• Epiberberine may be used as natural feed additive to reducing NH3 release in ruminants.

01 Nov 2024·Current Drug Research Reviews

Assessing the Efficacy of Berberine Hydrochloride-loaded Transethosomal Gel System in Treating Dermatophytosis Caused by Trichophyton rubrum in ex-vivo, in-vitro and in-vivo Models

Article

Author: Tiwari, Varsha ; Sharma, Ajay ; Singh, Sunil ; Tiwari, Abhishek ; Mishra, Koushlesh Kumar ; Kaur, Chanchal Deep

Background:Dermatophytosis is the most common dermatological disorder worldwide. Many drugs are available in the market for the treatment of dermatophytosis, but they have had limited success due to the stratum corneum barrier, antifungal resistance, drug permeation, drug retention in skin layers, etc. Thus, there is a constant need for new topical compounds that are effective against dermatophytosis. Berberine-hydrochloride is an attractive candidate to become an antifungal drug, and by using nanotechnology, it achieves deeper penetration in skin layers with enhanced permeability through the stratum corneum.Methods:In this study, we developed an oleic acid-containing berberine-hydrochloride-loaded transethosomal gel for effective treatment of dermatophytosis by Trichophyton rubrum. Berberine- hydrochloride-loaded transethosomal gels were fabricated using the hot homogenization method, followed by the incorporation of transethosomes into the gel-based system using carbopol 934. Transethosomal gel was characterized by physicochemical properties, in vitro drug release, ex-vivo permeation studies, CLSM visualization, antifungal activity, histopathological evaluation, and dermatokinetic study.Results:Berberine-hydrochloride-loaded transethosomes seemed to be spherical and found in a range between 200-300 nm. Berberine-hydrochloride-loaded transethosomal gel formulation also exhibited controlled ex-vivo permeation of berberine-hydrochloride over 24 hr through excised rat skin, and CLSM confirmed deeper penetration into skin layers. The in vivo study revealed that transethosomal gel had a healing effect on the skin of Wistar rats infected with Trichophyton rubrum and was better than luliconazole cream. The histopathological evaluation confirmed its safety, and the dermatokinetic study showed transethosomal gel superiority over marketed cream.Conclusion:Therefore, the incorporation of berberine hydrochloride-loaded transethosomal nanosystems into the gel has the potential to enhance antifungal activity and permeation through transdermal drug delivery.

01 Oct 2024·International Immunopharmacology

Synergistic berberine chloride and Curcumin-Loaded nanofiber therapies against Methicillin-Resistant Staphylococcus aureus Infection: Augmented immune and inflammatory responses in zebrafish wound healing

Article

Author: Prasad Panda, Siva ; Khan, Haroon ; Subramanian, Raghunandhakumar ; Guru, Ajay ; Arockiaraj, Jesu ; Kandaswamy, Karthikeyan ; Rafi Shaik, Mohammed ; Althaf Hussain, Shaik

BACKGROUNDWound healing pivots on a finely orchestrated inflammatory cascade, critical for tissue repair. Chronic wounds, compounded by persistent inflammation and susceptibility to infection, pose formidable clinical challenges. Nanofiber dressings offer promising avenues for wound care, yet their interaction with inflammation and infection remains elusive. We aim to delineate the inflammatory cascade preceding wound closure and assess Cu@Bbc nanofibers' therapeutic efficacy in mitigating inflammation and combating infection. Their unique attributes suggest promise in modulating inflammation, fostering tissue regeneration, and preventing microbial colonization. Investigating the intricate interplay between nanofiber scaffolds, inflammation, and infection may unveil mechanisms of enhanced wound healing. Our findings could stimulate the development of tailored dressings, urgently needed for effective wound management amidst immune dysregulation, infection, and inflammation.METHODSIn this investigation, we synthesized Cu@Bbc nanofibers, incorporating curcumin and berberine chloride, for wound healing applications. We evaluated their individual and combined antibacterial, anti-biofilm, and antioxidant activities, alongside binding affinity with pro-inflammatory cytokines through molecular docking. Morphological characterization was conducted via SEM, FTIR assessed functional groups, and wettability contact angle measured hydrophobic properties. The physical properties, including tensile strength, swelling behavior, and thermal stability, were evaluated using tensile testing, saline immersion method and thermogravimetric analysis. Biodegradability of the nanofibers was assessed through a soil burial test. Biocompatibility was determined via MTT assay, while wound healing efficacy was assessed with in vitro scratch assays. Controlled drug release and antibacterial activity against MRSA were examined, with in vivo assessment in a zebrafish model elucidating inflammatory responses and tissue remodeling.RESULTSIn this study, the synergistic action of curcumin and berberine chloride exhibited potent antibacterial efficacy against MRSA, with significant anti-mature biofilm disruption. Additionally, the combination demonstrated heightened antioxidant potential. Molecular docking studies revealed strong binding affinity with pro-inflammatory cytokines, suggesting a role in expediting the inflammatory response crucial for wound healing. Morphological analysis confirmed nanofiber quality, with drug presence verified via FTIR spectroscopy. Cu@Bbc demonstrated higher tensile strength, optimal swelling behavior, and robust thermal stability as evaluated through tensile testing and thermogravimetric analysis. Additionally, the Cu@Bbc nanofiber showed enhanced biodegradability, as confirmed by the soil burial test. Biocompatibility assessments showed favorable compatibility, while in vitro studies demonstrated potent antibacterial activity. In vivo zebrafish experiments revealed accelerated wound closure, re-epithelialization, and heightened immune response, indicative of enhanced wound healing.CONCLUSIONIn summary, our investigation highlights the efficacy of Cu@Bbc nanofibers, laden with curcumin and berberine chloride, in displaying robust antibacterial and antioxidant attributes while also modulating immune responses and inflammatory cascades essential for wound healing. These results signify their potential as multifaceted wound dressings for clinical implementation.

News (Medical) associated with Berberine Chloride Hydrate

30 Mar 2021

·www.globenewswire.com

CarboFix Reviews: Negative Side Effects or Real Ingredients?

Chicago, IL, March 26, 2021 (GLOBE NEWSWIRE) -- In need of a metabolic lift? Feel as though no matter how much you change your eating habits; your weight simply won’t shift? According to supplements’ provider, Gold Vida, such results are expected when the root cause for metabolic dysfunction is not dealt with. This means even the healthiest of diets and/or demanding exercises will do no good. Are there any other ways to address this? Gold Vida vows that they have the right solution that tackles weight management and guarantees that one’s metabolism is always running. Above all, their approach is believed to improve other aspects of life. With all that in mind, the following guide combines every part of the one and only, “CarboFix”. If you’re not new to the supplement industry, chances are you’ve heard this sales pitch before. Someone in a small, isolated village across the world discovered an incredible method of losing weight. Despite pushback from the traditional medical industry, brave researchers turned the method into an incredible new supplement. Most weight loss supplements have the same kind of backstory, and these tales work wonders to convert potential buyers into longtime customers. The CarboFix claims to have originally been discovered by a “99-year-old grandma” living in a small Ecuadorian village. We’re here to cut through the sales pitch and give you the bottom line about CarboFix, as well as other supplements in the growing weight loss formula market. The truth is that we can’t verify whether or not this formula was originally discovered in an Ecuadorian village. It could very well be the case that this 99-year-old grandmother never existed in the first place! However, getting bogged down in the details of a supplement’s backstory is a fantastic way to miss the point. The most important aspects of CarboFix carbohydrate management formula have more to do with its ingredients and research than the people who supposedly discovered it. The CarboFix official website claims that the titular product can provide five unique benefits to users. In addition to increasing fat-burning potential, it also purportedly decreases hunger, controls blood sugar, “increases longevity,” and directly leads to increased weight loss. These benefits are nothing to balk at; a supplement that can do all of this would certainly be worth nearly any price tag attached to it. It doesn’t really matter whether the formula was discovered in a lab or in a village in Ecuador. At the end of the day, our job is to research the scientific articles, people, and ingredients backing up this revolutionary new weight loss supplement. Should you use the CarboFix supplement to eat carbs guilt free? Scams are certainly popular within the weight loss sector. This review will serve as the ideal starting point for consumers looking to improve their understanding of the CarboFix formula, as well as the research and people behind it. What is CarboFix? CarboFix is an all-natural, carbohydrate management formula found exclusively at TheCarboFix.com that was designed to help consumers fight off belly fat, uncontrollable weight gain, and intense hunger and sugar cravings. One facet that is worth underlining here is the formula’s simplicity. In other words, CarboFix brings together the effects of six ingredients known to activate the metabolism switch found within our very bodies. Want in on the secrets? Let’s get right into CarboFix’s function. How does CarboFix work? CarboFix has been formulated to turn on a supposed “metabolism switch” called AMP-activated protein kinase (or AMPk for short). In so doing, a reduction in abdominal fat, a boost to one’s metabolism, and improved type 2 diabetes are likely explains Gold Vida’s personal nutrition coach, Matt Stirling. Before digging deeper into the CarboFix formula, we decided it might be a great idea to investigate evidence that currently links AMPk and the metabolism. Here’s what we gathered thus far: Based on the reportings of one review, AMPk is a type of enzyme that becomes activated whenever energy is consumed. It supposedly functions to restore cellular ATP levels by altering metabolic and cellular pathways. What’s interesting is that it can be activated in different parts of the body. For instance, when AMPk is activated in the liver, glucose, cholesterol and triglycerides production might be halted. In addition, studies have reported fatty acid oxidation, immediately implying increased energy levels, and a barricade that prevents toxins buildup in the blood [1]. Not only will fat storage be reduced (which validates the claims made by Matt Stirling), but an improvement might be witnessed in terms of insulin sensitivity (i.e., reduced insulin-resistance). In further researching the benefits of the metabolism switch, we came across another review [2] that highlighted the following about the satiety hormone, leptin: “Leptin suppresses the activity of acetyl coenzyme A carboxylase (ACC), thereby stimulating the oxidation of fatty acids in muscle […] Our data identify AMPk as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle.” (EXCLUSVE SAVINGS HERE) Buy Matt Stirling's CarboFix Supplement Directly From the Official Gold Vida Website Right Now What ingredients are in the CarboFix formula? Firstly to all those who look forward to making CarboFix capsules a part of their weight loss regime should know that this supplement is designed to be healthy. The capsule is formulated with only natural ingredients that have been broadly studied and confirmed to fight against uncontrollable weight gain, belly fat, and extreme hunger and cravings. Because of its all-natural formula, CarboFix capsules are also seen to improve type 2 diabetes, speed up the slowest metabolism, and improve cardiovascular health. One of the most beneficial things in consuming these capsules is that it doesn’t harm the health of people trying it because there is no chemical substance involved. Earlier, we mentioned that CarboFix contains six ingredients. Well, now’s the time to reveal them and below is a summary on what the scientific community has reported up until this point. As mentioned above CarboFix pills essentially consist of only plant-based ingredients and the details are also given on its official website. The entire formula is based on an all-natural approach ensuring that there are no side effects of using CarboFix capsules regularly. Also, there is no hidden accumulation of any toxic or chemicals or other particles in this product. Each ingredient used in the making of this capsule has been tested very well and these ingredients are shown by science to be very effective. None of the ingredients are synthetically developed because each ingredient is taken from its best available source. Here’s a look at the main ingredients that have been added in the formula: Berberine True cinnamon Alpha-lipoic acid Chromium Benfotiamine Naringin Berberine HCL (400mg/serving) Berberine HCL [3] is a chemical extracted from plants. Historically, it has been used as a treatment for diabetes, high levels of cholesterol, lipids in the blood and high blood pressure among others. One study [4] that investigated the metabolic effects of berberine in two animal models found that it “reduced body weight and caused a significant improvement in glucose tolerance without altering food intake.” The researchers explained that the “berberine treatment resulted in increased AMP-activated protein kinase […] increased GLUT4 translocation in L6 cells [and] reduced lipid accumulation.” Simply put, these factors suggest that berberine is especially beneficial for the purposes of treating diabetes and obesity. Cinnamomum verum (100mg/ serving) Also referred to as “true cinnamon” or “Ceylon cinnamon”, Cinnamomum verum is a plant native to Sri Lanka and southern parts of India. One review [5] that assessed the experimental evidence for cinnamon in terms of glucose levels summarized that it has “the potential to be a useful add-on therapy […] in managing type 2 diabetes.” A group of researchers [6] who previously reported the positive effect of cinnamon extract (CE) on type 1 diabetes decided to clarify the mechanisms of this spice. In the end, they were able to find that “CE ameliorates type 2 diabetes by inducing GLUT4 translocation via the AMPk signalling pathway,” adding that, “insulin antagonistically regulates the activation of AMPk.” Click Here to Buy the Official CarboFix Supplement with Studied and Tested Ingredients Today Alpha-lipoic Acid (50mg/ serving) Alpha-lipoic acid (ALA) is a chemical that mimics the effects of vitamin and is said to carry antioxidant properties. As for how ALA might come in handy, a study [7] that looked at its effects on triglyceride accumulation in skeletal muscle reported noteworthy results. To be more precise, this rats’ model indicated that ALA “increased insulin-stimulated glucose […] in the whole body.” Moreover, the researchers conveyed signs of “increased fatty acid oxidation and activated AMPk in the skeletal muscle.” Chromium Picolinate (200mcg/ serving) Chromium is an essential trace element that is commonly found in supplements. As per one source, chromium is responsible for producing a compound that enhances the insulin hormone. As a result, glucose levels may lower [8]. Based on a study that placed emphasis on the mechanisms of chromium, it was pinpointed that the ingredient (i.e., trivalent chromium) helped increase AMPk activity within the skeletal muscle. Consequently, factors including insulin sensitivity and transportation of glucose were enhanced as well [9]. Bentotiamine (80mg/ serving) Benfotiamine is a derivative of vitamin B1, also known as thiamine. According to existing findings, this vitamin can possibly support the body in the act of converting carbohydrates into fuel and metabolizing glucose. Remarkably, people who have discovered a thiamine deficiency were also predominantly obese, which makes sense seeing the role it plays on the metabolism [10]. Naringin derived from grapefruit (50mg/ serving) Naringin is a flavonoid glycoside that is found in many citrus fruits, one of them being grapefruit peels. A mice study that explored the effects of naringin on metabolic syndrome among those who were fed a high-fat diet found that it can, in fact, activate AMPk. This was supposedly because of the flavonoid’s antioxidant and anti-inflammatory properties, both of which are said to give rise to fatty acid oxidation, while exhibiting hypoglycemic and lipid-lowering effects [11]. It is assured that this supplement is free of gluten, GMO, soy, dairy as well as MSG. NEW SPECIAL SAVINGS: Buy the Gold Vida CarboFix Carb Management Formula by Matt Stirling While Supplies Last CarboFix Benefits: Real Positive Effects or Fake Results? There are three different steps in the working of CarboFix weight loss capsules. Here is an explanation to understand the working mechanism of this dietary supplement that will help you to make your decision whether or not it would be a worthwhile addition to your lifestyle: Enhances The Production Of AMPK Activated protein kinase plays a very vital role in burning the fats of your body. Not just this but it also converts the sugar into energy. However, because of the increasing storage of carbohydrates in the body leads to a decrease in AMPK production. Here CarboFix will help in processing carbohydrates in your body as they will be put to use and it will enhance the production of AMPK for weight loss. This way, your metabolic activity will speed up and you will be able to shed off excess pounds. Controls Your Appetite- CarboFix additionally helps you in overcoming your cravings by minimizing your hunger. Mostly it is your increased appetite that is the culprit behind your increasing weight. Regrettably, most people do not want to admit to this fact. CarboFix weight loss capsules suppress your appetite so that you eat only as much as the required nutrition by your body. This way there will be no excess carbs in your body and you will not gain those extra inches. Increases Carbohydrate Metabolism As per the growing age, your body processes carbohydrates differently at every stage. The older you get, the more carbohydrates in your body start getting stored which is why you are often recommended to lessen your carbohydrate intake. Here CarboFix fixes the problem by increasing carb metabolism so that carbs are converted into energy and end contributing to weight gain. By following these three different approaches which are interlinked, this supplement helps you achieve weight loss and maintain it too. CarboFix capsules comes with a wide range of benefits, here are some of the major pros that consumers can expect from it: Control Over Excessive Cravings And Hunger The formula in this capsule includes natural ingredients that make one feel fuller which consequently decreases hunger and appetite within no time. The major cause behind obesity is the constant urge to eat even after a complete meal, which leads to being overweight. CarboFix curbs the urge leading to great weight loss. Increases longevity CarboFix promotes a healthier and fitter lifestyle, helping its consumers to stay hale and hearty. Its ingredients minimize health risks that are associated with unhealthy weight ensuring a healthy long life. Boosts Fat Burning Process These weight loss supplements contain ingredients that are responsible for burning fat faster. This way a user will start to lose weight within no time effortlessly. Controls Blood Sugar Levels CarboFix also energetically controls and manages the body’s blood sugar levels, withdrawing many health risks associated with diabetes and obesity. Increases Energy Levels We all know weight loss can make a person feel quite low, however by consuming CarboFix weight loss capsules you will feel energetic throughout your weight loss journey. With a lightweight and a healthy body and mind, a user will automatically feel energetic and active throughout the day. Frequently Asked Questions (FAQs) CarboFix is a capsule designed for weight loss and for improving the body’s metabolism. This capsule can also help in controlling blood sugar levels, burning stubborn fat, increases weight loss by gradually decreasing hunger. There is a great obsession among the consumers that are following this program and many who aspire for weight loss are asking “Does CarboFix work? Before buying, people inquire about its effectiveness because there are many fraud schemes out there in the market that take advantage of human nature. Hence read on to know the most asked questions about the CarboFix weight loss formula and then make your decision. What is the recommended dose for CarboFix? As a dietary supplement, individuals should take one capsule with two of the largest, carbohydrates-containing meals of the day. For people who are currently on the keto diet, one capsule is still recommended, but with the two largest meals of the day. For maximum results, CarboFix should be combined with a healthy calorie reduced diet and regular exercise. What results are anticipated from taking CarboFix? As advertised, CarboFix might potentially help to increase fat-burning, weight loss, and longevity, while decreasing hunger and regulating blood sugar levels. Who should refrain from taking CarboFix? Children under the age of 18 years, pregnant/nursing mothers and/or people with any medical conditions are advised against taking CarboFix unless recommended by a physician. It is also important to note that taking any doses in excess within 24 hours can lead to unwanted consequences. What features does CarboFix have? At the time of writing, CarboFix was presented as a solution that is: 100% plant-based Free from any fillers, additives, and/or chemicals Non-GMO, and gluten-, soy-, MSG- and dairy-free Keto-friendly Distributed by Gold Vida, based in London, ON, Canada Financially risk-free, thanks to its 60-day, money-back guarantee How much does CarboFix cost? CarboFix has been mass-produced, with each bottle housing 60 capsules or 30 servings. That said, below is a prices rundown (excluding any applicable shipping fees) worth going over: 1 CarboFix bottle : $49 each : $49 each 3 CarboFix bottles : $42 each : $42 each 6 CarboFix bottles : $34 each : $34 each Buy CarboFix for the Lowest Price and Biggest Savings Directly from the Official Website TheCarboFix.com How does the CarboFix refund policy work? As explicitly above, individuals have 60 days to decide whether CarboFix is truly effective for their weight management goals. If, after a certain point, CarboFix fails to bring satisfactory results, customer service can be contacted for a full refund. Here are some ways of addressing this issue: Email : support@goldvida.com. : support@goldvida.com. Mailing Address: 2283 Yellowbirch Way, London, ON, Canada, N6G 0N3 Do CarboFix purchases come with bonuses as well? Yes, in addition to placing an order for CarboFix, Gold Vida will also offer the following bonus reports for supercharged results: Bonus #1. 10-Day Rapid Fat Loss Diet Although diet changes are allegedly not required when ingesting CarboFix, it is highly recommended. Making dietary changes can ensure a strong, healthy heart, cholesterol levels and blood pressure among others. Inside this guide, individuals will discover the secrets to eating carbohydrates without feeling guilt or storing fat, the number one fat-burning food to eat in the morning, what fit celebrities over 50 are doing to maintain their shape and the process of reprograming the body to burn fat. The whole point is to enjoy foods in moderate quantities so that the metabolism is active. Bonus #2. 24-Hour Fix The 24-Hour Fix has been designed to help get the fat-burning journey started. In it, individuals will come across tips and tricks that will help individuals to drop 5 pounds within a day. This is neither meant to be overwhelming nor exhausting. Again, the main focus is to make healthy tweaks to lifestyle choices. Bonus #3. 50 Fat Blasting Red Smoothies Finally, we have a recipe guide on smoothies that perfectly combine proteins, good fats and healthy carbohydrates to stimulate the body’s metabolic effects, all while increasing one’s energy levels. The beauty that rests within this bonus report is that all it takes is a handful of common household ingredients. Final Verdict All-in-all, CarboFix is a dietary supplement that aims to activate the switch to a smooth and sailing metabolism. The chosen ingredients are reasoned as having the capacities to enhance an enzyme called AMPk, which in return might naturally stimulate bodily hormones and create a balance among different bodily functions for ideal weight management. Our research suggests that everything explained by Gold Vida’s expert is valid, as all six ingredients have been studied to some extent. Though most results are based on animal models, the positive results have been accepted by the scientific community. It’s hard to say for sure whether or not The Carbo Fix will work for you. At the end of the day, metabolism is a complicated beast that the scientific community still fails to come to a definitive consensus on. But the metabolism nevertheless exists, and just dieting and exercising might not be enough to help you lose the weight you want to lose. The Carbo Fix uses a long list of all-natural ingredients to help people improve their metabolism. Research studies have approved the use of these ingredients for weight loss, as well as blood sugar regulation. At $49 per bottle, there’s nothing really unique about the price of this weight loss supplement. It’s also possible to save more money by buying several bottles at a time, although we would only really recommend this for people who are already sure that the product will work for them. CarboFix appears to be a reliable weight loss formula, offering a simple and effective weight loss solution to all those who want to be fit and healthy. The supplement uses high quality and all-natural ingredients to ensure a safe and healthy weight loss journey. The product is manufactured by following premium processes that guarantee top quality. The product is not just for weight loss but also helps in maintaining overall health as you can experience better management of your sugar levels as well. Hence, CarboFix is completely legit and a safe weight-loss solution. To learn more about Matt Stirling's Gold Vida CarboFix Supplement, visit the official website at TheCarboFix.com today! Official Website - Contact Details: CarboFix support@goldvida.com About MarketingByKevin.com This product review is published by Marketing By Kevin. Marketing By Kevin reviews are researched and formulated by a group of experienced natural health advocates with years of dedication and determination to finding the highest quality health products and wellness programs available. It should be noted that any purchase derived from this resource is done at your own peril. It is recommended to consult with a qualified professional healthcare practitioner before making an order today if there are any additional questions or concerns. Any order finalized from this release’s links are subject to the entire terms and conditions of the official website’s offer. The researched information above does not take any direct or indirect responsibility for its accuracy. Affiliate Disclosure: The links contained in this product review may result in a small commission to Marketing By Kevin if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products. Disclaimer: Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. Product support: support@goldvida.com Media Contact: info@marketingbykevin.com

21 Feb 2021

·www.globenewswire.com

CarboFix Reviews 2021 - Real Weight Loss Ingredients or Gold Vida Supplement Has Side Effects? Review by FitLivings

New York City, NY , Feb. 20, 2021 (GLOBE NEWSWIRE) -- CarboFix independent reviews 2021 update. This latest report reveals important information every consumer must know before buying. MUST READ: “Critical CarboFix Weight Loss Report - This May Change Your Mind” CarboFix is a natural dietary supplement put together to help users achieve faster weight loss by means of boosting metabolism in the body. According to its official website, the product comprises 100% natural ingredients that are backed by research. Thanks to its chemical-free formula, it is safe for use for everyone who wishes to get a slimmer, healthier body without adopting any strict dietary measures or following a regular exercise routine. Gold Vida CarboFix also aims to improve the overall health and wellbeing of the user by naturally boosting all the metabolic processes. It can also cut down the risk of obesity and cardiovascular complications while positively impacting mental health. (SPECIAL PROMO 2021) Click Here To Order CarboFix at an Exclusive Low Price For New Customers! Let’s admit it: most people are sick and tired of following diet plans. They are harsh, strict, and very difficult to comply within the long term. Moreover, it can often be demoralizing and sometimes even ineffective even after investing so much time and effort in it. While the medical community has sufficient proof to connect the role of an efficient metabolism with weight loss, not much research has been dedicated to this particular concept. Truth be told, it is the metabolism that helps some people lose weight so fast despite eating so much while making others obese no matter what they do to stop it. As a result, people are often left behind feeling frustrated, not knowing what to do to get a slimmer body of their dreams. However, with the recent boost of the supplement market, many companies have come forward with their own versions of natural metabolic boosters, such as the CarboFix supplement. SEE ALSO: We Found an Amazing Discounted Price For CarboFix Right Here! Gold Vida CarboFix Reviews - What Is New About This Metabolic Booster? Not many people are aware of the importance that metabolism plays in weight loss. Having a poor metabolism can, in fact, lead to a handful of issues including: Increased risk of certain diseases, including hypertension, heart problems, and diabetes Excessive fatigue Lack of motivation to accomplish daily chores Reduced fat-burning leading to increased weight gain More frequent cravings for unhealthy foods Frequent episodes of depression and mood swings Unfortunately, not many people are able to identify the signs of poor metabolism and keep taking help from random weight loss strategies that do not work out for them. As a result, they lose motivation and will to keep trying. Luckily, such people now have a better chance at losing weight by boosting their slowed-down metabolisms with CarboFix Gold Vida capsules. Marketed as a carbohydrate management formula, this supplement has been specially designed to target slow metabolism and increase its speed so that fat burning can take place at a higher speed. According to thecarbofix.com, using this supplement may help users experience: Faster fat burning Efficient weight loss Better control on blood sugar and blood pressure Lesser hunger pangs Improved quality of life As per the manufacturers of Gold Vida CarboFix pills, this formula is different as instead of taking a superficial route to weight loss, it works on the root cause to provide more permanent effects. It works by reversing the poor metabolism to improve fat burning and eliminate the risk of obesity. But how does CarboFix really work to improve metabolism and help with weight loss? Let’s look at it in the next section. Also check out what Gold Vida CarboFix customer reviews are saying about this product. Does it work for everyone? Visit The Official Website Here to Know More! How Does CarboFix Really Work To Improve Metabolism? The CarboFix supplement works to fix the metabolism by the activation of an enzyme called AMPk or AMP-activated protein kinase. This particular enzyme is found in all cells of the body and plays a critical role in all metabolic processes. This enzyme is responsible for converting the incoming fat and sugar molecules from the diet into energy. This energy released as a consequence of fat and sugar breakdown is then used by the body to fuel its other activities. At the same time, this energy is also used for decreasing unhealthy cravings and preventing the users from binging on junk. With these cravings reduced, you also avoid overeating and can get good control over your body weight. How does a lack of AMPk cause weight gain? A lot of people tend to suffer from a shortage of AMPk due to the presence of certain compounds known as fructans. These fructans are actually complex sugar polymers that are found in many food items that you consume on a daily basis, for example, vegetables, legumes, and fruits. The human body is not naturally equipped to handle fructans and break them down which is why these compounds become extremely dangerous for it. So as you keep consuming foods rich in fructans, the body is unable to break them down. So what it does instead is convert them into fat molecules and keep storing them in different parts. As a result, you suffer from symptoms like bloating, stomach issues, puffiness and increased weight gain. Furthermore, excessive fructan consumption also forces the body to release more insulin which, in turn, blocks the AMPk. This further reduces fat burning. Additionally, the normal process of aging also naturally reduces the body’s ability to produce AMPk. All these processes that lead to AMPk blockage increase fat deposition, leading to obesity. In such dire circumstances when weight loss seems like an impossible task, the CarboFix supplement by Gold Vida works to increase the production of AMPk inside the body. It also works on improving insulin sensitivity and regulates its release. As a result, users have a better chance of getting rid of all deposited fat cells and enjoying a slimmer body. MUST SEE: “Shocking CarboFix Report – What They’ll Never Tell You” CarboFix Ingredients List and Benefits The official website of CarboFix weight loss pills has clearly mentioned all the ingredients that have been added to its core formula to boost metabolism. All these ingredients have one thing in common: they are derived from natural sources of the highest quality. All these CarboFix ingredients are mentioned below in detail. Berberine HCl (400 mg) Berberine is an alkaloid that has been used by Chinese folks for the treatment of many issues, such as gastrointestinal problems. This natural plant extract has been made a part of Gold Vida CarboFix pills because they decrease the rate at which fat cells are being deposited in the body by reducing the expression of certain genes that promote weight gain. Moreover, berberine also decreases the blood levels of cholesterol, low-density lipoproteins, and total glycerides which, in turn, decrease the risk of obesity. Cinnamon Bark (100 mg) Cinnamon bark is a rich source of antioxidants and has been used by traditional medics to improve the health of the heart. Using it frequently can help reduce the impact of the myocardial injury on the body. Lastly, cinnamon bark also helps flush out all the harmful toxins from the body which may otherwise slow down the metabolism and lead to obesity. Alpha-lipoic Acid (50 mg) Alpha-lipoic acid is a naturally occurring powerful antioxidant that’s commonly added to multiple natural weight loss supplements due to its obesity-fighting effects. This ingredient in CarboFix metabolism supplement also assists in the production of energy inside a particular cell organelle called mitochondria. Many clinical trials have proven the properties of alpha-lipoic acid in reducing total body weight and fat mass. Chromium (200 mcg) Chromium is a nutrient essential for the regulation of the metabolism of both carbohydrates and lipids. It also helps decrease the total body fat content while increasing lean body mass. Furthermore, chromium also improves glycemic control by improving the action of insulin. Benfotiamine (80 mg) Benfotiamine is a type of water-soluble vitamin that helps in the regulation of energy by controlling metabolism. It also helps control cellular oxidative stress which boosts metabolism and helps in fat burning. Naringin (50 mg) Naringin is an important major flavonoid glycoside found in certain natural foods, such as grapefruit. This extract is particularly popular in Chinese medicine due to its anti-cancer and anti-inflammatory actions. Inside CarboFix, it promotes bone regeneration and speeds up the metabolism by reducing oxidative stress. For More Information On The CarboFix Ingredients, Check Out The Official Website Here Is CarboFix Legit? Evaluating The Pros and Cons To find out whether a product is legitimate or not, the best way is to make a list of its pros and cons and balance them out. In the light of the information mentioned by the manufacturers on the official website together with CarboFix independent reviews, the following pros and cons can be deduced for this supplement. Pros of CarboFix Pills Following are some beneficial features of CarboFix pills. No artificial compounds The makers of the CarboFix weight loss supplement have ensured that it does not contain any synthetic chemicals in its core formula. Moreover, these pills are completely free of soy, dairy, GMO, gluten, and MSG, making them extremely safe for use. Better weight loss With CarboFix pills, the body is able to stop the conversion of sugar into fat molecules which are then deposited in different parts and contribute to weight gain. By activating AMPk, an enzyme that initiates fat-burning processes, this supplement can help you lose pounds without the need for any diet plans or exercise. Regulation of blood sugar In a normal human body, not all incoming sugars are broken down to release energy. Instead, some of it is converted into fat cells and deposited in different areas of the body contributing to weight gain. However, if your body has the right amounts of certain enzymes, like AMPk, it can lead to the complete burning of sugars without converting any of them into fat cells. This enzyme can be boosted by using CarboFix capsules daily. Balanced hormones Gold Vida CarboFix supplement helps balance your hormones which, in turn, helps improve various factors like stress, mood swings, and unhealthy cravings for food. Additionally, the natural ingredients used in this formula also boost the overall energy levels and make you more productive. Competitive prices There are many dietary supplements available in the market offering similar benefits as CarboFix pills. However, most of them are extremely expensive and cannot be afforded by most people on a monthly basis. In contrast, CarboFix supplement reviews have rendered it as a cheap product that is available on exciting deals and discount packages which further reduce its price. As a result, most people can easily use them for as long as they like. Also See: “Why You REALLY Need CarboFix NOW!” Cons of CarboFix These pills do not possess any serious side effects or harmful aspects, as indicated by most CarboFix reviews online. Still, there are two things to keep in mind before you invest in this supplement. The issue of availability You are unable to buy CarboFix from any retail stores or online platforms such as Amazon. The only way to order them is via their official website. However, if you really think about it, it is to reduce the risk of encountering any CarboFix scam and help users get their hands on the authentic product at minimal prices only. Limitation of use People who are already on some other medication for any underlying medical condition are to refrain from using this product. Similarly, this product is not intended to be used by underage individuals. (LIMITED TIME DEAL) Click Here To Order Gold Vida CarboFix From Its Official Website Who Should Use Gold Vida CarboFix Supplement? If you are someone who has been fighting obesity for a long time and tried everything to get rid of the excess pounds but to no avail, CarboFix pills are for you. This natural supplement targets the main cause of obesity along with all the uncomfortable symptoms it brings about, and that too without relying on crazy diet plans or strenuous exercises. Sometimes, exercises and diet plans just don’t seem to work out for some people, no matter how hard they try. This is because the main problem lies within their metabolism which has been slowed down due to a number of factors. CarboFix capsules help remove all these negative factors and give users a chance to maximize their fat burning. In short, if obesity has been your companion for a long time and you are in search of a true supplement with no side effects that can help you get rid of it, the CarboFix supplement is for you. Gold Vida CarboFix Side Effects and Safety Profile The manufacturers of CarboFix metabolism supplement have rendered it a game-changer as far as weight loss is concerned. But what makes it even better is that it does its job without causing any side effects. According to the official website, this minimal risk of side effects associated with this supplement is due to its following characteristics: It is made using the purest natural ingredients CarboFix pills have been made by using natural extracts taken from plants. The plants from which the nutrients and minerals have been extracted are owned by authentic vendors that do not use any chemicals in their growing phases. Moreover, the final supplement is completely free from any dangerous or harmful supplements so the risk of encountering any CarboFix side effects automatically decreases. It has been validated by research The core formula of these capsules has not been designed overnight. Instead, it has been formulated step by step using CarboFix ingredients that are backed by research. All these ingredients have been proven to possess metabolic boosting and anti-obesity properties. Click Here to Order The CarboFix Supplement From Its Official Website While Supplies Last Who Should Refrain From Using CarboFix? According to thecarbofix.com, CarboFix comprises a herbal formula with a strong potential to accelerate weight loss. However, just because it does not possess any side effects and is not loaded with chemicals does not mean anyone can use it. The following groups of people are recommended to refrain from using CarboFix pills. Pregnant women and lactating mothers must steer clear of this product, particularly because its effects have not been evaluated in this particular group and it may harm the baby, the mother, or both. If you are currently on any prescription or OTC drug, do not combine CarboFix capsules with it. This is because there is a risk of cross-reaction that can not only reduce the efficacy of one or both but may also damage the body. If you are suspicious that you suffer from an undiagnosed underlying medical problem, it is better to refrain from CarboFix capsules until you consult your physician first. If you are allergic to even one of the CarboFix ingredients mentioned on its label, do not take this supplement as it may lead to a potentially life-threatening allergic reaction. CarboFix by Gold Vida is meant for adults and is not to be taken by individuals below the age of 18 years. CarboFix Dosage & Tips to Begin The CarboFix supplement is available in the form of capsules that are to be taken orally. These capsules are extremely convenient to use as you do not need to measure any ingredients or prepare them beforehand. To kick start your weight loss journey with CarboFix in 2021, you have to take two capsules with a glass of water. Make sure you time the intake with two of your largest meals loaded with carbohydrates. According to the manufacturers, CarboFix may start showing visible effects within 72 hours of use. However, to see the proper benefits of CarboFix pills that tend to last for a longer duration of time, you must keep consuming this supplement for at least 30 days without a break. The longer you use it, the more astonishing the results. However, individual results may vary. The official website recommends ordering at least 3 bottles of CarboFix pills to get your weight loss journey started. However, if you buy more bottles together, it is only going to help you more with weight loss while saving some money. Combining the use of CarboFix with light exercise and a healthy diet plan is recommended as it is going to lead to even faster weight loss results. MUST SEE: “Surprising CarboFix Report – You Will Not Believe This” Where To Buy CarboFix? Pricing, Shipping and Refund Policy CarboFix is available for purchase on its official website, thecarbofix.com. Here, the product is available in the form of three separate plans. The information on these plans is mentioned below. One bottle of the supplement with 60 capsules, enough to last a month is for $49 only Three bottles of the supplement, enough to last for three months is for $42 per bottle only Six bottles of the supplement, enough to last for six months is for $34 only This means that buying in bulk is going to help you save lots of money while letting you stock up on this supplement so that you do not need to reorder it, again and again, every month. For all CarboFix Australia and Canada users, make sure to stick to the official website for purchasing it to avoid any scams. Gold Vida CarboFix supplement is currently being offered with a money-back guarantee that lasts up to 60 days from the date of purchase. So if you do not see any improvements with this supplement, you can always return it and get your money back. The manufacturers are currently giving up two free bonus items on the purchase of CarboFix pills. These bonuses include: 10-day rapid fat loss diet book This book serves as your personal coach and guides you about the necessary changes to make in your diet that can trigger effective weight loss. 50 fat-blasting red smoothies This recipe book has 50 different recipes of yummy smoothies that can aid in your weight loss journey. CarboFix Reviews - Concluding Thoughts All in all, CarboFix seems like a legitimate solution to weight gain that relies on completely natural ingredients to safely induce weight loss. It comes from Gold Vida, a company that has invested a lot of time and struggle to assure its efficacy, safety, and affordability. By naturally increasing your fat-burning potential and triggering your metabolism, it can help you to achieve your weight loss goal in 2021. To learn more or to place your CarboFix order at a discounted price today, visit the official website using this link. Product Contact: Gold Vida CarboFix support@goldvida.com About Fit Livings: This press release has been created by Fit Livings, a USA based company that provides consumers with product reviews and reports helping them make informed decisions. Individual results may vary and this product review has been published for information purposes only. Any purchase done from this link is subject to the final terms and conditions of the website that is selling the product. To contact Fit Livings regarding this press release, please email at info@fitlivings.com FDA and Supplements: The FDA will never approve a dietary supplement. According to the Food and Drug Administration, dietary supplements are a category of their own, and they are not subject to FDA regulation or approval. If a company is claiming that the FDA approves their diet supplement, run. This is a clear misrepresentation. -- This statement has not been evaluated by the Food and Drug Administration. 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100 Deals associated with Berberine Chloride Hydrate

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KEGG	Wiki	ATC	Drug Bank
D01250	Berberine Chloride Hydrate	J	-

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Indication	Country/Location	Organization	Date
Diarrhea	JP	Nichi-Iko Pharmaceutical Co., Ltd.	01 Jul 1994
Intestinal infections	CN	Hubei Huazhong Pharmaceutical Co. Ltd.	01 Jan 1981
Infectious Diseases	-	-	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ESMO_MAP2021	Not Applicable	Neoplasm Metastasis	-	Berberine Chloride	uudunhajla(wommsvksno) = iiognfgdek vdjmoyiksk (cxntwlqasr ) View more	-	06 Oct 2021
NCT03909763 (CTgov)	Phase 2	Purpura, Thrombocytopenic, Idiopathic	55	Berberine+danazol	snkeejcebz(djbqzsnvly) = mgdsrhlrut hcutuammpr (ojasbztfxm, kljhoxfiit - gkkhcmsoqb) View more	-	25 Sep 2020

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