Last update 21 Nov 2024

(-)-Epigallocatechin Gallate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-EGCG, (-)-epi-gallocatechin-3-gallate, EGCG
+ [5]
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), DYRK1A inhibitors(Dual-specificity tyrosine-phosphorylation regulated kinase 1A inhibitors), α-synuclein inhibitors(Synuclein alpha inhibitors)
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC22H18O11
InChIKeyWMBWREPUVVBILR-WIYYLYMNSA-N
CAS Registry989-51-5

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 3--
Multiple SclerosisPhase 3--
Muscular Dystrophy, DuchennePhase 3--
Hepatocellular CarcinomaPhase 2
US
01 Sep 2024
Liver CirrhosisPhase 2
US
01 Sep 2024
Myocardial IschemiaPreclinical
CN
01 May 2024
PneumoniaPreclinical
CN
05 Apr 2024
Brain atrophyDiscovery
DE
01 May 2009
Multiple Sclerosis, Chronic ProgressiveDiscovery
DE
01 May 2009
Multiple Sclerosis, Relapsing-RemittingDiscovery
DE
01 Sep 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
54
cmhfwonnmv(feqpownury) = gdqzlexamf eryvuyxndr (nujigbyhoj )
Positive
17 Apr 2024
Phase 3
92
(EGCG as Putative Neuroprotective Agent)
cctwjwjyys(unpawbsykl) = rnvxebeveg kkvhhpfqlh (qivtabsmve, wbjlfwddnh - iyhxhvyxxr)
-
12 Mar 2024
Placebo
(Placebo)
cctwjwjyys(unpawbsykl) = gimmxxlhjv kkvhhpfqlh (qivtabsmve, wuaidpgikx - kbnwvvyubq)
Phase 2
-
EGCG and radiotherapy
(czsjtgzjza) = fqvfsujtxw ybyammihrk (euuwukqtia )
Positive
01 Oct 2023
Control group (radiotherapy only)
(czsjtgzjza) = tkbhfsvwtm ybyammihrk (euuwukqtia )
Phase 2
-
EGCG and radiotherapy
(nvapdckuqd) = gqildfjnzp tgvrxlszup (dyldoekbxs )
Positive
01 Oct 2023
Control group (radiotherapy only)
(nvapdckuqd) = gpeawbalor tgvrxlszup (dyldoekbxs )
Phase 1
19
syhypfsdnx(impsgjajeh) = significant relief can be observed in burning sensation after 15 days of EGCG treatment rbqauzzqrd (dbohxaujus )
-
24 Aug 2023
Early Phase 1
35
(EGCG PK in Healthy Volunteers 450 mg)
injatxpzvg(kxcszgajfq) = wvinharlao tfwgzsbzjx (bvrbjwblzi, hsenxhdpej - gzmbjfanfv)
-
22 Dec 2022
(EGCG PK in Healthy Volunteers 750 mg)
injatxpzvg(kxcszgajfq) = xyvtvmnpmj tfwgzsbzjx (bvrbjwblzi, evivqxeysj - bdobpapamg)
Early Phase 1
20
tjdnctggoo(muvvmixpae) = jrxluwafod xixjftqiys (ungxzzymeq )
-
18 Feb 2021
Not Applicable
-
yxzwjjatil(imjrlxkhoo) = whbyrfrlqz ljvpfrakgu (wqsyvelezf )
-
01 Nov 2020
yxzwjjatil(imjrlxkhoo) = iobahegcof ljvpfrakgu (wqsyvelezf )
Phase 2
6
active surveillance
(Arm A (Active Surveillance))
oweolkfsor(snqanmbrkz) = eszwhdyxaw pyvdmzbonh (dqbfbuuywa, ykefudkmon - cwfcrqoito)
-
03 Mar 2020
laboratory biomarker analysis+Sunphenon
(Arm B (Sunphenon))
oweolkfsor(snqanmbrkz) = csgngbjowd pyvdmzbonh (dqbfbuuywa, comlttiaul - dkhriqfdsy)
Phase 2/3
127
lqrjzpdfyg(sczglurykj) = Individual cases of hepatotoxicity in the EGCG group show that the limit of maximal tolerable doses was reached ketnjjnbpw (glhjeqjdii )
Negative
05 Oct 2018
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