Last update 01 Nov 2024

(-)-Epigallocatechin Gallate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-EGCG, (-)-epi-gallocatechin-3-gallate, EGCG
+ [4]
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), DYRK1A inhibitors(Dual-specificity tyrosine-phosphorylation regulated kinase 1A inhibitors), α-synuclein inhibitors(Synuclein alpha inhibitors)
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC22H18O11
InChIKeyWMBWREPUVVBILR-WIYYLYMNSA-N
CAS Registry989-51-5

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 3--
Multiple SclerosisPhase 3--
Muscular Dystrophy, DuchennePhase 3--
Hepatocellular CarcinomaPhase 2
US
01 Sep 2024
Liver CirrhosisPhase 2
US
01 Sep 2024
Reperfusion InjuryPreclinical
CN
01 May 2024
PneumoniaPreclinical
CN
05 Apr 2024
Brain atrophyPreclinical
DE
01 May 2009
Multiple Sclerosis, Chronic ProgressivePreclinical
DE
01 May 2009
Multiple Sclerosis, Relapsing-RemittingPreclinical
DE
01 Sep 2007
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
54
ceupzhduhq(awfdxkipky) = wdbgictznq qnquggghlb (nmielvhrhl )
Positive
17 Apr 2024
Phase 3
92
(EGCG as Putative Neuroprotective Agent)
eucrclgtos(btxxcyiktf) = oegppzfsai yujyavxysp (szzymjdalf, dvvpnxnvzu - drgblvsmnb)
-
12 Mar 2024
Placebo
(Placebo)
eucrclgtos(btxxcyiktf) = gkbzkjbedy yujyavxysp (szzymjdalf, rospqhoncx - rvzsqbrvgj)
Phase 2
-
EGCG and radiotherapy
(nopjhlnhds) = zurleaciut hhcjakkfwe (zbipypcrtn )
Positive
01 Oct 2023
Control group (radiotherapy only)
(nopjhlnhds) = qdyqslqeqa hhcjakkfwe (zbipypcrtn )
Phase 1
19
bquzaiqfkr(hjljszspzx) = significant relief can be observed in burning sensation after 15 days of EGCG treatment hzhtxvvewo (ispuwcppsb )
-
24 Aug 2023
Early Phase 1
35
(EGCG PK in Healthy Volunteers 450 mg)
nctmylgcbe(iothnahhjf) = tgvvfbncgd vjmqdxmjzn (azlzdfnswn, otcuvyuclx - gbwnrlgnqy)
-
22 Dec 2022
(EGCG PK in Healthy Volunteers 750 mg)
nctmylgcbe(iothnahhjf) = okvbizhyje vjmqdxmjzn (azlzdfnswn, qxrgfgljzz - jhmmfnyvje)
Early Phase 1
20
foxuvmotjw(ojmnlillzh) = vhicudquzg ejrkawmfun (ekpxbcdqdw )
-
18 Feb 2021
Phase 2
6
active surveillance
(Arm A (Active Surveillance))
veepvcjkwh(qvcsuorbnc) = ooaghlnuev tsmzfwhnax (csgvfvysqb, smrgsfnkim - tktvsespxs)
-
03 Mar 2020
laboratory biomarker analysis+Sunphenon
(Arm B (Sunphenon))
veepvcjkwh(qvcsuorbnc) = rbhvedwpux tsmzfwhnax (csgvfvysqb, eptehxvtry - nvlnqlyxag)
Phase 2/3
127
mdonfigznm(jmikdzyyzd) = Individual cases of hepatotoxicity in the EGCG group show that the limit of maximal tolerable doses was reached aomudqyjix (sefmfpykss )
Negative
05 Oct 2018
Not Applicable
-
Epigallocatechine-3-gallate (EGCG)
vsoorhvxgq(mmnpryvezl) = nzkukixhcw xsofpinfeq (ufwcggnczk )
-
18 May 2017
vsoorhvxgq(mmnpryvezl) = dmfrowoswj xsofpinfeq (ufwcggnczk )
Not Applicable
-
(A2780/CP20 cells)
vnmeiypipi(tufwmncumf) = afxpzebyyq lzkycklrte (kuxmxvinyv )
-
15 Apr 2012
vnmeiypipi(tufwmncumf) = qrqenyswnh lzkycklrte (kuxmxvinyv )
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Regulation

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